SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oz6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2oz6 VIRULENCE FACTOR
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 8 VAL A 201
VAL A 144
VAL A 148
ILE A 172
 None
 0.81A 1igxA-2oz6A:
undetectable		 1igxA-2oz6A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2oz6 VIRULENCE FACTOR
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 8 VAL A 210
VAL A 144
VAL A 148
ILE A 172
LEU A 195
 None
 1.50A 1igxA-2oz6A:
undetectable		 1igxA-2oz6A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 2oz6 VIRULENCE FACTOR
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 188
VAL A 201
CYH A 183
ARG A 179
 None
 1.28A 1t46A-2oz6A:
undetectable		 1t46A-2oz6A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2oz6 VIRULENCE FACTOR
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 8 MET A 187
VAL A 203
LEU A 195
VAL A 181
 None
 1.03A 2bdmA-2oz6A:
undetectable		 2bdmA-2oz6A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2oz6 VIRULENCE FACTOR
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 8 VAL A 210
LEU A 195
VAL A 191
VAL A 181
 None
 1.01A 2bdmA-2oz6A:
undetectable		 2bdmA-2oz6A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2oz6 VIRULENCE FACTOR
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 8 TYR A  65
ILE A 172
ILE A 180
ARG A 179
ILE A 177
 None
 1.28A 2bu8A-2oz6A:
undetectable		 2bu8A-2oz6A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 2oz6 VIRULENCE FACTOR
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 10 VAL A  99
ILE A  44
ILE A  51
VAL A  91
VAL A  49
 None
None
CMP  A 301 ( 4.1A)
CMP  A 301 ( 4.9A)
None
 1.10A 3me6A-2oz6A:
undetectable		 3me6A-2oz6A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 2oz6 VIRULENCE FACTOR
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 5 PHE A  71
ILE A  32
MET A 125
PHE A  42
 None
CMP  A 301 ( 4.3A)
None
None
 1.36A 3octA-2oz6A:
undetectable		 3octA-2oz6A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 2oz6 VIRULENCE FACTOR
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 10 VAL A 188
LEU A 192
VAL A 191
LEU A 152
THR A 151
 None
 0.97A 4e3hA-2oz6A:
undetectable		 4e3hA-2oz6A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2W_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 2oz6 VIRULENCE FACTOR
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 188
LEU A 192
VAL A 191
LEU A 152
THR A 151
 None
 0.94A 4m2wA-2oz6A:
undetectable		 4m2wA-2oz6A:
20.85