SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oze'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		4 / 6 LEU A  40
ASP A 178
MET A  70
LEU A  79
 None
 1.19A 1errB-2ozeA:
undetectable		 1errB-2ozeA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		3 / 3 ILE A  71
ILE A 158
THR A 162
 None
 0.41A 1rg7A-2ozeA:
2.8		 1rg7A-2ozeA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		5 / 12 ASP A 156
LEU A  66
ILE A 159
MET A 181
PHE A 283
 None
 1.45A 1xomA-2ozeA:
undetectable		 1xomA-2ozeA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		5 / 12 ASP A 156
LEU A  66
ILE A 159
MET A 181
PHE A 283
 None
 1.37A 1xoqA-2ozeA:
undetectable		 1xoqA-2ozeA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		5 / 12 ASP A 156
LEU A  66
ILE A 159
MET A 181
PHE A 283
 None
 1.41A 1xoqB-2ozeA:
undetectable		 1xoqB-2ozeA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		5 / 12 LEU A 125
LEU A 100
LEU A 105
ILE A 119
ILE A  71
 None
 0.99A 2bxqA-2ozeA:
undetectable		 2bxqA-2ozeA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		3 / 3 LYS A  33
GLY A 211
PRO A 210
 None
 0.43A 2hreB-2ozeA:
3.2		 2hreB-2ozeA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		4 / 5 LEU A  40
ASP A 178
MET A  70
LEU A  79
 None
 1.26A 2jfaA-2ozeA:
undetectable		 2jfaA-2ozeA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		4 / 6 ARG A 289
GLY A 216
PHE A 247
PRO A 219
 None
 1.37A 2m2oB-2ozeA:
undetectable		 2m2oB-2ozeA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		5 / 12 LEU A 143
ASN A 172
ALA A 173
LEU A 125
THR A 132
 None
 1.16A 2oaxC-2ozeA:
undetectable		 2oaxC-2ozeA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		4 / 5 LEU A  40
ASP A 178
MET A  70
LEU A  79
 None
 1.23A 2qxsA-2ozeA:
undetectable		 2qxsA-2ozeA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		4 / 5 LEU A  40
ASP A 178
MET A  70
LEU A  79
 None
 1.23A 2qxsB-2ozeA:
undetectable		 2qxsB-2ozeA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		4 / 8 TRP A 260
ASP A  62
HIS A 268
LEU A  64
 None
 1.16A 3ablA-2ozeA:
undetectable
3ablC-2ozeA:
undetectable
3ablP-2ozeA:
undetectable		 3ablA-2ozeA:
18.92
3ablC-2ozeA:
19.29
3ablP-2ozeA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		4 / 8 LEU A  64
TRP A 260
ASP A  62
HIS A 268
 None
 1.16A 3ablC-2ozeA:
undetectable
3ablN-2ozeA:
undetectable
3ablP-2ozeA:
undetectable		 3ablC-2ozeA:
19.29
3ablN-2ozeA:
18.92
3ablP-2ozeA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		4 / 8 LEU A  64
TRP A 260
ASP A  62
HIS A 268
 None
 1.17A 3asnC-2ozeA:
undetectable
3asnN-2ozeA:
undetectable
3asnP-2ozeA:
undetectable		 3asnC-2ozeA:
19.29
3asnN-2ozeA:
18.92
3asnP-2ozeA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		4 / 8 TRP A 260
ASP A  62
HIS A 268
LEU A  64
 None
 1.21A 3asoA-2ozeA:
undetectable
3asoC-2ozeA:
undetectable
3asoP-2ozeA:
undetectable		 3asoA-2ozeA:
18.92
3asoC-2ozeA:
19.29
3asoP-2ozeA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		4 / 8 LEU A  64
TRP A 260
ASP A  62
HIS A 268
 None
 1.18A 3asoC-2ozeA:
undetectable
3asoN-2ozeA:
undetectable
3asoP-2ozeA:
undetectable		 3asoC-2ozeA:
19.29
3asoN-2ozeA:
18.92
3asoP-2ozeA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		5 / 12 ASP A 156
LEU A  66
ILE A 159
MET A 181
PHE A 283
 None
 1.36A 3g4lB-2ozeA:
undetectable		 3g4lB-2ozeA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		5 / 10 ILE A 182
PHE A 217
SER A 190
LEU A 236
HIS A 240
 None
 1.28A 3o1cA-2ozeA:
undetectable		 3o1cA-2ozeA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		5 / 12 LEU A 143
ASN A 172
ALA A 173
LEU A 125
THR A 132
 None
 1.25A 3vhuA-2ozeA:
undetectable		 3vhuA-2ozeA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		4 / 6 THR A 113
ASN A 115
ASP A 117
ILE A 109
 None
 1.44A 3w9tB-2ozeA:
undetectable		 3w9tB-2ozeA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		4 / 8 TRP A 260
ASP A  62
HIS A 268
LEU A  64
 None
 1.19A 3x2qA-2ozeA:
undetectable
3x2qC-2ozeA:
undetectable
3x2qP-2ozeA:
undetectable		 3x2qA-2ozeA:
18.92
3x2qC-2ozeA:
19.29
3x2qP-2ozeA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		3 / 3 ASP A  74
LYS A  73
ASP A  72
 None
 0.57A 4a7tA-2ozeA:
undetectable		 4a7tA-2ozeA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		5 / 12 LEU A 144
LEU A 143
LEU A 105
ILE A 160
ILE A 158
 None
 1.09A 4j24A-2ozeA:
undetectable		 4j24A-2ozeA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		5 / 12 LEU A  60
LEU A  66
ILE A  39
ILE A 159
LEU A  53
 None
 1.29A 4j26B-2ozeA:
undetectable		 4j26B-2ozeA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		3 / 3 ARG A  27
LEU A  23
GLU A  24
 None
 0.65A 4l3gF-2ozeA:
undetectable		 4l3gF-2ozeA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		5 / 12 LEU A  40
ALA A 173
THR A  78
ILE A 159
LYS A  50
 None
None
AGS  A 300 ( 4.7A)
None
AGS  A 300 (-2.6A)
 1.12A 4o2bB-2ozeA:
undetectable		 4o2bB-2ozeA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		5 / 12 LEU A  66
VAL A  68
ILE A  39
VAL A 282
LEU A  53
 None
 0.99A 4y0qA-2ozeA:
undetectable		 4y0qA-2ozeA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		5 / 12 LEU A 212
ILE A  37
ILE A 215
GLY A 216
LEU A 201
 None
 0.75A 4y8wC-2ozeA:
undetectable		 4y8wC-2ozeA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		4 / 8 TRP A 260
ASP A  62
HIS A 268
LEU A  64
 None
 1.16A 5b1bA-2ozeA:
undetectable
5b1bC-2ozeA:
undetectable
5b1bP-2ozeA:
undetectable		 5b1bA-2ozeA:
18.92
5b1bC-2ozeA:
19.29
5b1bP-2ozeA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		4 / 8 LEU A  64
TRP A 260
ASP A  62
HIS A 268
 None
 1.16A 5iy5C-2ozeA:
undetectable
5iy5N-2ozeA:
undetectable
5iy5P-2ozeA:
undetectable		 5iy5C-2ozeA:
19.29
5iy5N-2ozeA:
18.92
5iy5P-2ozeA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		5 / 9 ALA A 149
ILE A 119
LEU A  69
ILE A 109
ASN A 104
 None
 0.94A 5nunA-2ozeA:
undetectable		 5nunA-2ozeA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		4 / 6 LYS A  50
VAL A 180
ILE A 174
TYR A 197
 AGS  A 300 (-2.6A)
None
None
None
 1.45A 5q1sA-2ozeA:
1.8		 5q1sA-2ozeA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		3 / 3 GLY A  99
ASN A 102
ARG A  93
 None
 0.68A 5w7bD-2ozeA:
4.0		 5w7bD-2ozeA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		4 / 8 TRP A 260
ASP A  62
HIS A 268
LEU A  64
 None
 1.20A 5xdqA-2ozeA:
undetectable
5xdqC-2ozeA:
undetectable
5xdqP-2ozeA:
undetectable		 5xdqA-2ozeA:
18.92
5xdqC-2ozeA:
19.29
5xdqP-2ozeA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		4 / 8 LEU A  64
TRP A 260
ASP A  62
HIS A 268
 None
 1.18A 5xdqC-2ozeA:
undetectable
5xdqN-2ozeA:
undetectable
5xdqP-2ozeA:
undetectable		 5xdqC-2ozeA:
19.29
5xdqN-2ozeA:
18.92
5xdqP-2ozeA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		5 / 11 ILE A 119
LEU A 125
PHE A  96
LEU A 144
ILE A  71
 None
 0.93A 5z6mA-2ozeA:
2.7		 5z6mA-2ozeA:
21.15