SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ozk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 10 MET A 218
GLU A 210
ARG A 198
ILE A 235
LEU A 227
 None
 1.43A 1a52A-2ozkA:
undetectable		 1a52A-2ozkA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 10 MET A 218
GLU A 210
ARG A 198
ILE A 235
LEU A 227
 None
 1.46A 1a52B-2ozkA:
undetectable		 1a52B-2ozkA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 12 LEU A  72
ASN A  73
LEU A  75
GLY A  76
VAL A 121
 None
 1.03A 1gs4A-2ozkA:
undetectable		 1gs4A-2ozkA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		6 / 9 PHE A 232
VAL A 236
LEU A 250
PHE A 221
MET A 209
SER A 207
 None
 1.44A 1wrkA-2ozkA:
undetectable
1wrkB-2ozkA:
undetectable		 1wrkA-2ozkA:
14.88
1wrkB-2ozkA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 7 PHE A 232
LEU A 250
PHE A 221
MET A 209
SER A 207
 None
 1.42A 1wrlA-2ozkA:
undetectable
1wrlB-2ozkA:
undetectable		 1wrlA-2ozkA:
14.88
1wrlB-2ozkA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		6 / 6 PHE A 232
VAL A 236
LEU A 250
PHE A 221
MET A 209
SER A 207
 None
 1.35A 1wrlB-2ozkA:
undetectable		 1wrlB-2ozkA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 7 PHE A 232
LEU A 250
PHE A 221
MET A 209
SER A 207
 None
 1.44A 1wrlE-2ozkA:
undetectable		 1wrlE-2ozkA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 12 LEU A  72
ASN A  73
LEU A  75
GLY A  76
VAL A 121
 None
 0.99A 2q7lA-2ozkA:
undetectable		 2q7lA-2ozkA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 8 GLU A  68
SER A 197
GLN A 159
VAL A 172
 None
 0.74A 3b9lA-2ozkA:
undetectable		 3b9lA-2ozkA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 5 PRO A 157
THR A 120
VAL A  77
GLY A  76
 None
 0.96A 3elzA-2ozkA:
undetectable		 3elzA-2ozkA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 5 SER A 207
ASP A 296
ASP A 323
ILE A 322
 None
 1.34A 3uj7B-2ozkA:
undetectable		 3uj7B-2ozkA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 12 PRO A 157
LEU A 122
ILE A  85
ALA A 160
SER A 161
 None
 1.43A 4a83A-2ozkA:
undetectable		 4a83A-2ozkA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 8 GLY A 253
PHE A 240
ILE A 295
PHE A 329
 None
 0.95A 4fglD-2ozkA:
undetectable		 4fglD-2ozkA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 6 GLY A 253
PHE A 240
ILE A 295
PHE A 329
 None
 1.08A 4qogA-2ozkA:
undetectable
4qogB-2ozkA:
undetectable		 4qogA-2ozkA:
22.44
4qogB-2ozkA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		3 / 3 MET A 251
ASP A 267
PHE A 268
 None
 1.04A 4xeyA-2ozkA:
undetectable		 4xeyA-2ozkA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		3 / 3 MET A 251
ASP A 267
PHE A 268
 None
 1.04A 4xeyB-2ozkA:
undetectable		 4xeyB-2ozkA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		3 / 3 ILE A 295
MET A 271
ASP A 323
 None
 0.83A 5h2uA-2ozkA:
undetectable		 5h2uA-2ozkA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 5 GLY A 169
PRO A 157
THR A 174
GLN A 159
 None
 1.07A 5h5fA-2ozkA:
undetectable		 5h5fA-2ozkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 12 VAL A  77
LEU A  57
HIS A  95
ALA A  80
PRO A  67
 None
 1.39A 5syfB-2ozkA:
undetectable		 5syfB-2ozkA:
22.25