SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ozo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 7 PRO A 110
ASP A   3
SER A  14
ALA A   5
 None
 0.95A 1gxsA-2ozoA:
undetectable
1gxsB-2ozoA:
undetectable		 1gxsA-2ozoA:
16.50
1gxsB-2ozoA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 7 ALA A 137
GLU A 136
LEU A 138
VAL A 127
 None
 0.94A 1hk2A-2ozoA:
undetectable		 1hk2A-2ozoA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 8 SER A 144
VAL A 314
SER A 313
LYS A 151
 None
 1.19A 1hwiB-2ozoA:
undetectable		 1hwiB-2ozoA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 8 SER A 144
VAL A 314
SER A 313
LYS A 151
 None
 1.18A 1hwkD-2ozoA:
undetectable		 1hwkD-2ozoA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 9 LEU A 344
GLY A 345
VAL A 352
ALA A 367
ALA A 417
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.9A)
ANP  A 615 (-4.7A)
 0.69A 1muoA-2ozoA:
9.6		 1muoA-2ozoA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		3 / 3 SER A  14
GLY A  13
ARG A 119
 None
 0.37A 1t9wA-2ozoA:
undetectable		 1t9wA-2ozoA:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 9 LEU A 344
ALA A 367
MET A 414
MET A 416
ALA A 417
GLY A 419
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 ( 3.7A)
ANP  A 615 (-3.9A)
None
ANP  A 615 (-4.7A)
 0.90A 1xbbA-2ozoA:
32.2		 1xbbA-2ozoA:
30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 9 LEU A 344
VAL A 352
ALA A 367
MET A 414
GLY A 418
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 ( 4.0A)
ANP  A 615 (-4.7A)
 1.19A 1xbbA-2ozoA:
32.2		 1xbbA-2ozoA:
30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 9 LEU A 344
VAL A 352
ALA A 367
MET A 414
MET A 416
ALA A 417
GLY A 420
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 ( 3.7A)
ANP  A 615 (-3.9A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
 0.71A 1xbbA-2ozoA:
32.2		 1xbbA-2ozoA:
30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 9 LEU A 344
VAL A 352
MET A 414
MET A 416
ALA A 417
GLY A 420
PRO A 421
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 ( 3.9A)
ANP  A 615 ( 3.7A)
ANP  A 615 (-3.9A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-3.7A)
ANP  A 615 (-4.7A)
 0.79A 1xbbA-2ozoA:
32.2		 1xbbA-2ozoA:
30.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 9 LEU A 344
VAL A 352
LYS A 369
LEU A 401
LEU A 412
LEU A 482
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.1A)
None
None
None
 0.91A 1xkkA-2ozoA:
31.6		 1xkkA-2ozoA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 11 GLY A 345
GLY A 347
VAL A 352
ALA A 367
MET A 414
ALA A 417
LEU A 468
 ANP  A 615 ( 4.4A)
ANP  A 615 (-3.6A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-3.9A)
ANP  A 615 (-4.7A)
 0.54A 2evaA-2ozoA:
25.5		 2evaA-2ozoA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 LEU A 344
VAL A 352
ALA A 367
MET A 414
ASN A 466
ASP A 479
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 ( 3.3A)
MG  A 614 ( 3.2A)
 0.80A 2fumC-2ozoA:
23.5		 2fumC-2ozoA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 LEU A 344
GLY A 345
GLY A 347
VAL A 352
ALA A 367
MET A 414
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-3.6A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
 0.49A 2fumD-2ozoA:
23.7		 2fumD-2ozoA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
GLY A 347
VAL A 352
ALA A 367
MET A 414
ASN A 466
ASP A 479
 ANP  A 615 (-4.4A)
ANP  A 615 (-3.6A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 ( 3.3A)
MG  A 614 ( 3.2A)
 0.90A 2fumD-2ozoA:
23.7		 2fumD-2ozoA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		3 / 3 GLN A 444
LYS A 476
VAL A 467
 None
 0.74A 2jfaB-2ozoA:
undetectable		 2jfaB-2ozoA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		3 / 3 GLU A 454
GLN A 591
ARG A 594
 None
 0.67A 2w3bB-2ozoA:
undetectable		 2w3bB-2ozoA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 5 SER A 144
TYR A 597
VAL A 149
TYR A 397
 None
 1.28A 2x7hA-2ozoA:
undetectable		 2x7hA-2ozoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 5 SER A 144
TYR A 597
VAL A 149
TYR A 397
 None
 1.28A 2x7hB-2ozoA:
undetectable		 2x7hB-2ozoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		3 / 3 ARG A 594
GLU A 453
SER A 144
 None
 0.91A 2xkkA-2ozoA:
3.4
2xkkC-2ozoA:
3.3		 2xkkA-2ozoA:
21.95
2xkkC-2ozoA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 8 LEU A 344
ALA A 367
MET A 414
GLY A 418
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 ( 4.0A)
ANP  A 615 (-4.7A)
 1.34A 2yfxA-2ozoA:
24.5		 2yfxA-2ozoA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 8 LEU A 344
ALA A 367
MET A 414
GLY A 419
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
None
ANP  A 615 (-4.7A)
 1.01A 2yfxA-2ozoA:
24.5		 2yfxA-2ozoA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 8 LEU A 344
ALA A 367
MET A 414
GLY A 420
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
 0.59A 2yfxA-2ozoA:
24.5		 2yfxA-2ozoA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 10 LEU A 344
ALA A 367
LYS A 369
VAL A 399
GLY A 419
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
None
ANP  A 615 (-4.7A)
 0.88A 3aoxA-2ozoA:
24.8		 3aoxA-2ozoA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 10 LEU A 344
ALA A 367
LYS A 369
VAL A 399
GLY A 420
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
 0.65A 3aoxA-2ozoA:
24.8		 3aoxA-2ozoA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		9 / 12 VAL A 352
ALA A 367
MET A 390
LEU A 401
GLY A 418
LEU A 468
ASP A 479
PHE A 480
LEU A 482
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
None
None
ANP  A 615 ( 4.0A)
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
None
None
 1.16A 3bbtB-2ozoA:
31.7		 3bbtB-2ozoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 VAL A 352
ALA A 367
MET A 390
LEU A 401
GLY A 419
LEU A 468
ASP A 479
PHE A 480
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
None
None
None
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
None
 0.89A 3bbtB-2ozoA:
31.7		 3bbtB-2ozoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		9 / 12 VAL A 352
ALA A 367
MET A 390
LEU A 401
GLY A 420
LEU A 468
ASP A 479
PHE A 480
LEU A 482
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
None
None
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
None
None
 0.80A 3bbtB-2ozoA:
31.7		 3bbtB-2ozoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 VAL A 352
ALA A 367
LYS A 369
MET A 390
GLY A 419
ASP A 479
PHE A 480
LEU A 482
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
None
MG  A 614 ( 3.2A)
None
None
 0.97A 3bbtD-2ozoA:
31.8		 3bbtD-2ozoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		9 / 12 VAL A 352
ALA A 367
LYS A 369
MET A 390
LEU A 412
GLY A 418
ASP A 479
PHE A 480
LEU A 482
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
None
ANP  A 615 ( 4.0A)
MG  A 614 ( 3.2A)
None
None
 1.05A 3bbtD-2ozoA:
31.8		 3bbtD-2ozoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		9 / 12 VAL A 352
ALA A 367
LYS A 369
MET A 390
LEU A 412
GLY A 420
ASP A 479
PHE A 480
LEU A 482
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
None
ANP  A 615 ( 3.9A)
MG  A 614 ( 3.2A)
None
None
 1.04A 3bbtD-2ozoA:
31.8		 3bbtD-2ozoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 VAL A 352
ALA A 367
MET A 390
GLY A 419
LEU A 468
ASP A 479
PHE A 480
LEU A 482
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
None
None
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
None
None
 1.08A 3bbtD-2ozoA:
31.8		 3bbtD-2ozoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		9 / 12 VAL A 352
ALA A 367
MET A 390
LEU A 412
GLY A 418
LEU A 468
ASP A 479
PHE A 480
LEU A 482
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
None
None
ANP  A 615 ( 4.0A)
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
None
None
 1.28A 3bbtD-2ozoA:
31.8		 3bbtD-2ozoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		9 / 12 VAL A 352
ALA A 367
MET A 390
LEU A 412
GLY A 420
LEU A 468
ASP A 479
PHE A 480
LEU A 482
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
None
None
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
None
None
 0.96A 3bbtD-2ozoA:
31.8		 3bbtD-2ozoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 12 VAL A 604
GLU A  82
GLY A  79
ILE A  61
HIS A  77
 None
 1.37A 3bwyA-2ozoA:
undetectable		 3bwyA-2ozoA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
GLY A 345
ALA A 367
LYS A 369
VAL A 399
GLY A 419
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
None
ANP  A 615 (-4.7A)
 0.84A 3c7qA-2ozoA:
23.9		 3c7qA-2ozoA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
GLY A 345
ALA A 367
LYS A 369
VAL A 399
GLY A 420
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
 0.92A 3c7qA-2ozoA:
23.9		 3c7qA-2ozoA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 LEU A 344
GLY A 345
GLY A 347
GLY A 350
VAL A 352
ALA A 367
LYS A 369
MET A 414
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-3.6A)
None
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
ANP  A 615 ( 3.9A)
 0.69A 3eygA-2ozoA:
26.7		 3eygA-2ozoA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 LEU A 344
GLY A 345
GLY A 347
GLY A 350
VAL A 352
ALA A 367
LYS A 369
MET A 414
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-3.6A)
None
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
ANP  A 615 ( 3.9A)
 0.78A 3fupA-2ozoA:
21.9		 3fupA-2ozoA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 LEU A 344
GLY A 345
GLY A 347
GLY A 350
VAL A 352
ALA A 367
MET A 414
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-3.6A)
None
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
 0.82A 3fupA-2ozoA:
21.9		 3fupA-2ozoA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
GLY A 345
VAL A 352
ALA A 367
LYS A 369
VAL A 399
MET A 414
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
ANP  A 615 ( 3.9A)
 0.76A 3lxkA-2ozoA:
27.0		 3lxkA-2ozoA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 11 ALA A 367
LYS A 369
VAL A 399
GLY A 418
LEU A 468
SER A 478
ASP A 479
 ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
ANP  A 615 ( 4.0A)
ANP  A 615 (-4.7A)
MG  A 614 ( 4.1A)
MG  A 614 ( 3.2A)
 1.23A 3miyA-2ozoA:
29.4		 3miyA-2ozoA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 12 TYR A 178
GLU A 172
ALA A 173
SER A 179
LEU A 188
 None
 1.44A 3ou6D-2ozoA:
undetectable		 3ou6D-2ozoA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 12 ALA A 601
LEU A 600
LEU A 533
ALA A 570
LEU A 571
 None
 1.26A 3ozuA-2ozoA:
undetectable		 3ozuA-2ozoA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
VAL A 399
GLY A 420
LEU A 468
ASP A 479
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
 0.61A 3qlgB-2ozoA:
28.4		 3qlgB-2ozoA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		9 / 12 GLY A 347
GLY A 350
VAL A 352
ALA A 367
LYS A 369
VAL A 399
LEU A 468
SER A 478
ASP A 479
 ANP  A 615 (-3.6A)
None
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
ANP  A 615 (-4.7A)
MG  A 614 ( 4.1A)
MG  A 614 ( 3.2A)
 0.91A 3v5wA-2ozoA:
8.3		 3v5wA-2ozoA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 11 LEU A 344
ALA A 367
LYS A 369
VAL A 399
GLY A 420
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
 0.87A 4agdA-2ozoA:
22.4		 4agdA-2ozoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 9 LEU A 344
VAL A 352
ALA A 367
MET A 414
GLY A 420
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
 0.63A 4ansA-2ozoA:
24.6		 4ansA-2ozoA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 11 LEU A 344
GLY A 345
GLY A 347
VAL A 352
ALA A 367
ALA A 417
GLY A 420
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-3.6A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.9A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
 0.77A 4ckiA-2ozoA:
24.0		 4ckiA-2ozoA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 11 LEU A 344
GLY A 345
VAL A 352
ALA A 367
ALA A 417
GLY A 418
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.9A)
ANP  A 615 ( 4.0A)
ANP  A 615 (-4.7A)
 1.08A 4ckiA-2ozoA:
24.0		 4ckiA-2ozoA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 10 LEU A 344
GLY A 345
VAL A 352
ALA A 367
ALA A 417
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.9A)
ANP  A 615 (-4.7A)
 0.47A 4ckjA-2ozoA:
27.9		 4ckjA-2ozoA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 12 GLY A 536
ALA A 532
THR A 528
VAL A 438
VAL A 427
 None
 1.30A 4df3A-2ozoA:
2.4		 4df3A-2ozoA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 12 GLY A  44
GLY A  45
TYR A  69
VAL A 114
PHE A  11
 None
 1.15A 4fglA-2ozoA:
undetectable
4fglB-2ozoA:
undetectable		 4fglA-2ozoA:
16.81
4fglB-2ozoA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
LYS A 369
GLY A 418
LEU A 468
ASP A 479
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
ANP  A 615 ( 4.0A)
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
 1.13A 4hjoA-2ozoA:
31.3		 4hjoA-2ozoA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
LYS A 369
GLY A 420
LEU A 468
ASP A 479
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
 0.87A 4hjoA-2ozoA:
31.3		 4hjoA-2ozoA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 LEU A 344
GLY A 345
VAL A 352
ALA A 367
LYS A 369
LEU A 412
GLY A 418
ASP A 479
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
ANP  A 615 ( 4.0A)
MG  A 614 ( 3.2A)
 0.86A 4i22A-2ozoA:
30.5		 4i22A-2ozoA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 GLY A 345
VAL A 352
ALA A 367
LYS A 369
LEU A 401
LEU A 412
GLY A 419
 ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
None
None
 0.74A 4ifgA-2ozoA:
23.5		 4ifgA-2ozoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 10 ALA A 367
VAL A 399
GLY A 420
LEU A 468
SER A 478
ASP A 479
 ANP  A 615 (-3.3A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
MG  A 614 ( 4.1A)
MG  A 614 ( 3.2A)
 1.06A 4ks8A-2ozoA:
22.8		 4ks8A-2ozoA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 10 ALA A 367
VAL A 399
MET A 414
GLY A 418
LEU A 468
SER A 478
 ANP  A 615 (-3.3A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 ( 4.0A)
ANP  A 615 (-4.7A)
MG  A 614 ( 4.1A)
 1.26A 4ks8A-2ozoA:
22.8		 4ks8A-2ozoA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 10 ALA A 367
VAL A 399
MET A 414
GLY A 419
LEU A 468
SER A 478
 ANP  A 615 (-3.3A)
None
ANP  A 615 ( 3.9A)
None
ANP  A 615 (-4.7A)
MG  A 614 ( 4.1A)
 0.98A 4ks8A-2ozoA:
22.8		 4ks8A-2ozoA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 10 ALA A 367
VAL A 399
MET A 414
GLY A 420
LEU A 468
SER A 478
 ANP  A 615 (-3.3A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
MG  A 614 ( 4.1A)
 0.85A 4ks8A-2ozoA:
22.8		 4ks8A-2ozoA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 7 VAL A 352
ALA A 367
MET A 414
LEU A 468
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
 0.49A 4l9iA-2ozoA:
9.3		 4l9iA-2ozoA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 8 GLY A 347
VAL A 352
ALA A 367
LYS A 369
MET A 414
LEU A 468
 ANP  A 615 (-3.6A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
 0.76A 4l9iB-2ozoA:
19.8		 4l9iB-2ozoA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 12 LYS A 369
MET A 414
ASN A 466
ASP A 479
PHE A 480
 ANP  A 615 (-3.1A)
ANP  A 615 ( 3.9A)
ANP  A 615 ( 3.3A)
MG  A 614 ( 3.2A)
None
 0.71A 4lmnA-2ozoA:
23.8		 4lmnA-2ozoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 11 LEU A 344
GLY A 345
VAL A 352
ALA A 367
LYS A 369
ASN A 466
LEU A 468
ASP A 479
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
ANP  A 615 ( 3.3A)
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
 0.95A 4o0sA-2ozoA:
22.7		 4o0sA-2ozoA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 6 VAL A 352
ALA A 367
LYS A 369
LEU A 468
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
ANP  A 615 (-4.7A)
 0.55A 4o0uA-2ozoA:
9.7		 4o0uA-2ozoA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 8 LEU A 344
VAL A 352
ALA A 417
HIS A 459
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.9A)
None
ANP  A 615 (-4.7A)
 1.02A 4qrcA-2ozoA:
28.1		 4qrcA-2ozoA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 6 LEU A 344
VAL A 352
ILE A 398
ILE A 477
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
None
None
 0.45A 4tyjA-2ozoA:
28.2		 4tyjA-2ozoA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 10 LEU A 344
VAL A 352
LEU A 393
ILE A 398
VAL A 399
ILE A 477
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
None
None
None
None
 0.88A 4u0iA-2ozoA:
26.6		 4u0iA-2ozoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 VAL A 352
ALA A 367
ALA A 417
LEU A 452
HIS A 459
GLY A 481
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.9A)
None
None
None
 0.74A 4v04A-2ozoA:
27.8		 4v04A-2ozoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 10 LEU A 344
VAL A 352
ARG A 460
LEU A 468
ILE A 477
LEU A 482
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
None
ANP  A 615 (-4.7A)
None
None
 0.78A 4v04B-2ozoA:
28.1		 4v04B-2ozoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 12 ALA A 367
ALA A 417
LEU A 452
HIS A 459
GLY A 481
 ANP  A 615 (-3.3A)
ANP  A 615 (-3.9A)
None
None
None
 0.70A 4v04B-2ozoA:
28.1		 4v04B-2ozoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 8 LEU A 344
ALA A 367
MET A 414
LEU A 468
SER A 478
 ANP  A 615 (-4.4A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
MG  A 614 ( 4.1A)
 0.56A 4wboB-2ozoA:
19.7		 4wboB-2ozoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 6 LEU A 344
ALA A 367
MET A 414
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
 0.44A 4wboC-2ozoA:
19.8		 4wboC-2ozoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
LYS A 369
VAL A 399
GLY A 420
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
 0.74A 4xeyA-2ozoA:
24.6		 4xeyA-2ozoA:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 12 VAL A 604
GLU A  82
GLY A  79
ILE A  61
HIS A  77
 None
 1.38A 4xucA-2ozoA:
undetectable		 4xucA-2ozoA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 12 VAL A 604
GLU A  82
GLY A  79
ILE A  61
HIS A  77
 None
 1.42A 4xudA-2ozoA:
undetectable		 4xudA-2ozoA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 7 LYS A 228
LEU A  43
GLY A  45
GLY A  44
 None
 0.83A 5a06B-2ozoA:
undetectable		 5a06B-2ozoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 LEU A 344
VAL A 352
ALA A 367
LYS A 369
GLY A 418
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
ANP  A 615 ( 4.0A)
ANP  A 615 (-4.7A)
 1.17A 5h2uA-2ozoA:
31.7		 5h2uA-2ozoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 LEU A 344
VAL A 352
ALA A 367
LYS A 369
GLY A 420
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
 0.75A 5h2uA-2ozoA:
31.7		 5h2uA-2ozoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
LYS A 369
GLY A 420
LEU A 468
ASP A 479
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
 0.83A 5h2uB-2ozoA:
31.9		 5h2uB-2ozoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 12 LEU A 344
ALA A 367
LYS A 369
LEU A 468
ASP A 479
 ANP  A 615 (-4.4A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
 0.59A 5h2uC-2ozoA:
31.6		 5h2uC-2ozoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 6 VAL A 467
ALA A 475
GLN A 444
VAL A 445
 None
 0.86A 5i8fA-2ozoA:
undetectable		 5i8fA-2ozoA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 12 VAL A 604
GLU A  82
GLY A  79
ILE A  61
HIS A  77
 None
 1.38A 5lsaA-2ozoA:
undetectable		 5lsaA-2ozoA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 11 LEU A 344
GLY A 345
VAL A 352
ALA A 367
VAL A 399
ALA A 417
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
None
ANP  A 615 (-3.9A)
ANP  A 615 (-4.7A)
 0.59A 5lvnA-2ozoA:
21.4		 5lvnA-2ozoA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 10 LEU A 344
VAL A 352
ALA A 367
VAL A 399
MET A 414
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
 0.83A 5n3hA-2ozoA:
19.7		 5n3hA-2ozoA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 VAL A 352
ALA A 367
LYS A 369
MET A 390
GLY A 418
LEU A 468
SER A 478
PHE A 480
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
ANP  A 615 ( 4.0A)
ANP  A 615 (-4.7A)
MG  A 614 ( 4.1A)
None
 1.35A 5p9iA-2ozoA:
30.7		 5p9iA-2ozoA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 VAL A 352
ALA A 367
LYS A 369
MET A 390
GLY A 420
LEU A 468
SER A 478
PHE A 480
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
MG  A 614 ( 4.1A)
None
 0.64A 5p9iA-2ozoA:
30.7		 5p9iA-2ozoA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		3 / 3 HIS A 459
SER A 478
ARG A 465
 None
MG  A 614 ( 4.1A)
ANP  A 615 (-4.2A)
 0.83A 5u63A-2ozoA:
undetectable		 5u63A-2ozoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 9 LEU A 344
ALA A 367
VAL A 399
MET A 414
GLY A 419
 ANP  A 615 (-4.4A)
ANP  A 615 (-3.3A)
None
ANP  A 615 ( 3.9A)
None
 0.78A 5w5vA-2ozoA:
15.6		 5w5vA-2ozoA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 9 LEU A 344
ALA A 367
VAL A 399
MET A 414
GLY A 420
 ANP  A 615 (-4.4A)
ANP  A 615 (-3.3A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 ( 3.9A)
 0.85A 5w5vA-2ozoA:
15.6		 5w5vA-2ozoA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 12 LEU A 344
GLY A 345
VAL A 352
ALA A 367
GLY A 418
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 4.0A)
 0.60A 5xv7A-2ozoA:
19.8		 5xv7A-2ozoA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		9 / 12 LEU A 344
GLY A 345
VAL A 352
ALA A 367
LYS A 369
MET A 390
LEU A 412
LEU A 468
ASP A 479
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
None
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
 0.82A 5yu9A-2ozoA:
30.5		 5yu9A-2ozoA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
GLY A 345
VAL A 352
ALA A 367
MET A 390
MET A 414
ASP A 479
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
None
ANP  A 615 ( 3.9A)
MG  A 614 ( 3.2A)
 1.11A 5yu9A-2ozoA:
30.5		 5yu9A-2ozoA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 GLY A 345
VAL A 352
ALA A 367
LYS A 369
MET A 390
LEU A 412
LEU A 468
ASP A 479
 ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
None
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
 0.78A 5yu9B-2ozoA:
30.9		 5yu9B-2ozoA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 GLY A 345
VAL A 352
ALA A 367
LYS A 369
MET A 390
MET A 414
LEU A 468
ASP A 479
 ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
 1.06A 5yu9B-2ozoA:
30.9		 5yu9B-2ozoA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 VAL A 352
ALA A 367
LYS A 369
MET A 390
LEU A 412
GLY A 420
ASP A 479
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
None
ANP  A 615 ( 3.9A)
MG  A 614 ( 3.2A)
 0.76A 5yu9C-2ozoA:
22.7		 5yu9C-2ozoA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 VAL A 352
ALA A 367
MET A 390
MET A 414
GLY A 420
ASP A 479
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 ( 3.9A)
MG  A 614 ( 3.2A)
 1.18A 5yu9C-2ozoA:
22.7		 5yu9C-2ozoA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 VAL A 352
LYS A 369
MET A 390
LEU A 412
GLY A 418
ASP A 479
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.1A)
None
None
ANP  A 615 ( 4.0A)
MG  A 614 ( 3.2A)
 1.01A 5yu9C-2ozoA:
22.7		 5yu9C-2ozoA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 VAL A 352
ALA A 367
LYS A 369
MET A 390
GLY A 420
LEU A 468
ASP A 479
LEU A 482
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
None
 0.88A 5yu9D-2ozoA:
30.9		 5yu9D-2ozoA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 VAL A 352
ALA A 367
LYS A 369
MET A 390
MET A 414
GLY A 420
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 ( 3.9A)
 1.09A 5yu9D-2ozoA:
30.9		 5yu9D-2ozoA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 VAL A 352
LYS A 369
MET A 390
GLY A 418
LEU A 468
ASP A 479
LEU A 482
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.1A)
None
ANP  A 615 ( 4.0A)
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
None
 1.44A 5yu9D-2ozoA:
30.9		 5yu9D-2ozoA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		3 / 3 ILE A 364
ASN A 336
CYH A 405
 None
 0.88A 6bp4A-2ozoA:
undetectable		 6bp4A-2ozoA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 7 PHE A 586
ALA A 464
VAL A 438
LEU A 442
 None
 0.70A 6dwnB-2ozoA:
undetectable		 6dwnB-2ozoA:
8.39