SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p0a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 2p0a SYNAPSIN-3
(Homo
sapiens) 		5 / 12 GLU A 284
VAL A 226
VAL A 246
LYS A 248
LYS A 260
 ANP  A 707 (-3.7A)
EDO  A 601 (-3.9A)
ANP  A 707 ( 4.7A)
ANP  A 707 (-2.9A)
None
 1.32A 3qwuA-2p0aA:
3.6		 3qwuA-2p0aA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 2p0a SYNAPSIN-3
(Homo
sapiens) 		3 / 3 ARG A 165
ASP A  98
TRP A 104
 SO4  A 701 ( 3.9A)
SO4  A 701 ( 4.8A)
None
 1.19A 4xdqA-2p0aA:
undetectable		 4xdqA-2p0aA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2p0a SYNAPSIN-3
(Homo
sapiens) 		4 / 4 VAL A 238
ALA A 240
PHE A 231
THR A 229
 None
 1.36A 4z4fA-2p0aA:
2.9		 4z4fA-2p0aA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2p0a SYNAPSIN-3
(Homo
sapiens) 		4 / 4 VAL A 238
ALA A 240
PHE A 231
THR A 229
 None
 1.35A 4z4hA-2p0aA:
3.1		 4z4hA-2p0aA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 2p0a SYNAPSIN-3
(Homo
sapiens) 		4 / 5 HIS A 251
MET A 367
ASN A 200
VAL A 198
 None
SO4  A 702 (-2.8A)
None
None
 1.32A 5xdhD-2p0aA:
undetectable		 5xdhD-2p0aA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2p0a SYNAPSIN-3
(Homo
sapiens) 		5 / 10 LEU A 129
VAL A 164
VAL A 181
ALA A 168
LEU A 184
 None
 1.12A 6czmA-2p0aA:
2.7
6czmC-2p0aA:
undetectable		 6czmA-2p0aA:
23.76
6czmC-2p0aA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2p0a SYNAPSIN-3
(Homo
sapiens) 		4 / 8 ILE A 293
VAL A 366
ARG A 294
ASP A 381
 None
None
SO4  A 702 (-4.1A)
None
 0.96A 6hu9a-2p0aA:
undetectable
6hu9e-2p0aA:
undetectable		 6hu9a-2p0aA:
18.06
6hu9e-2p0aA:
16.67