SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p0k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 2p0k POLYCOMB PROTEIN
SCMH1
(Homo
sapiens) 		5 / 12 LEU A  88
LEU A  83
GLY A  82
ALA A  78
PHE A 101
 None
 1.19A 1gs4A-2p0kA:
undetectable		 1gs4A-2p0kA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 2p0k POLYCOMB PROTEIN
SCMH1
(Homo
sapiens) 		3 / 3 TYR A 210
ARG A 217
GLN A  49
 None
 0.88A 1tw4A-2p0kA:
undetectable		 1tw4A-2p0kA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 2p0k POLYCOMB PROTEIN
SCMH1
(Homo
sapiens) 		3 / 3 SER A 107
ASP A 215
ASP A 218
 None
 0.78A 2plwA-2p0kA:
undetectable		 2plwA-2p0kA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 2p0k POLYCOMB PROTEIN
SCMH1
(Homo
sapiens) 		4 / 8 PHE A  28
THR A  37
THR A 188
VAL A 222
 None
 0.95A 2qbmA-2p0kA:
undetectable		 2qbmA-2p0kA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2p0k POLYCOMB PROTEIN
SCMH1
(Homo
sapiens) 		3 / 3 ARG A 217
ILE A 184
TRP A 224
 None
 1.15A 3e68A-2p0kA:
undetectable		 3e68A-2p0kA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2p0k POLYCOMB PROTEIN
SCMH1
(Homo
sapiens) 		4 / 6 HIS A  45
HIS A 164
SER A 163
ASP A 106
 None
 1.35A 4blvA-2p0kA:
undetectable		 4blvA-2p0kA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2p0k POLYCOMB PROTEIN
SCMH1
(Homo
sapiens) 		4 / 7 LEU A 104
ILE A 184
THR A 228
GLY A  85
 None
 0.87A 4eq4A-2p0kA:
undetectable		 4eq4A-2p0kA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2p0k POLYCOMB PROTEIN
SCMH1
(Homo
sapiens) 		4 / 7 LEU A 104
ILE A 184
THR A 228
GLY A  85
 None
 0.87A 4eqlA-2p0kA:
undetectable		 4eqlA-2p0kA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2p0k POLYCOMB PROTEIN
SCMH1
(Homo
sapiens) 		4 / 7 LEU A 104
ILE A 184
THR A 228
GLY A  85
 None
 0.85A 4eqlB-2p0kA:
undetectable		 4eqlB-2p0kA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2p0k POLYCOMB PROTEIN
SCMH1
(Homo
sapiens) 		4 / 6 LEU A 104
ILE A 184
THR A 228
GLY A  85
 None
 0.83A 4l39A-2p0kA:
undetectable		 4l39A-2p0kA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2p0k POLYCOMB PROTEIN
SCMH1
(Homo
sapiens) 		4 / 7 LEU A 104
ILE A 184
THR A 228
GLY A  85
 None
 0.80A 4l39B-2p0kA:
undetectable		 4l39B-2p0kA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2p0k POLYCOMB PROTEIN
SCMH1
(Homo
sapiens) 		4 / 8 THR A 200
CYH A 212
TYR A 210
LEU A 173
 None
 1.36A 6cnjD-2p0kA:
undetectable
6cnjE-2p0kA:
undetectable		 6cnjD-2p0kA:
16.76
6cnjE-2p0kA:
17.79