SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p0l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 2p0l LIPOATE-PROTEIN
LIGASE A
(Streptococcus
agalactiae) 		4 / 8 LEU A  49
ILE A 240
VAL A  13
ILE A  15
 None
 0.62A 1d4yB-2p0lA:
undetectable		 1d4yB-2p0lA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 2p0l LIPOATE-PROTEIN
LIGASE A
(Streptococcus
agalactiae) 		4 / 6 ASP A 263
GLU A 261
TRP A  32
ARG A  42
 None
 0.88A 2ouzA-2p0lA:
undetectable		 2ouzA-2p0lA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2p0l LIPOATE-PROTEIN
LIGASE A
(Streptococcus
agalactiae) 		5 / 12 TYR A 197
GLY A  90
GLY A  91
ALA A 166
PHE A  89
 None
 1.05A 3jayA-2p0lA:
1.6		 3jayA-2p0lA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 2p0l LIPOATE-PROTEIN
LIGASE A
(Streptococcus
agalactiae) 		5 / 12 LEU A 180
SER A 181
LEU A 155
ASP A 154
SER A 190
 None
 1.21A 3ko0M-2p0lA:
undetectable
3ko0N-2p0lA:
undetectable
3ko0O-2p0lA:
undetectable
3ko0P-2p0lA:
undetectable		 3ko0M-2p0lA:
18.68
3ko0N-2p0lA:
18.68
3ko0O-2p0lA:
18.68
3ko0P-2p0lA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 2p0l LIPOATE-PROTEIN
LIGASE A
(Streptococcus
agalactiae) 		5 / 12 PHE A 127
ALA A   9
LEU A 239
MET A 238
LEU A  49
 None
 1.05A 3s79A-2p0lA:
undetectable		 3s79A-2p0lA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2p0l LIPOATE-PROTEIN
LIGASE A
(Streptococcus
agalactiae) 		5 / 12 GLY A  99
LEU A 221
ALA A 163
LEU A 155
ALA A  96
 None
 1.17A 5jglB-2p0lA:
undetectable		 5jglB-2p0lA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 2p0l LIPOATE-PROTEIN
LIGASE A
(Streptococcus
agalactiae) 		5 / 12 PHE A 127
ALA A   9
LEU A 239
MET A 238
LEU A  49
 None
 1.01A 5jkvA-2p0lA:
undetectable		 5jkvA-2p0lA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2p0l LIPOATE-PROTEIN
LIGASE A
(Streptococcus
agalactiae) 		3 / 3 LYS A   4
LEU A  49
ILE A 131
 None
 0.77A 5kc4A-2p0lA:
undetectable		 5kc4A-2p0lA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 2p0l LIPOATE-PROTEIN
LIGASE A
(Streptococcus
agalactiae) 		4 / 7 VAL A 231
TYR A  19
GLU A 232
LEU A  49
 None
 1.17A 5umwB-2p0lA:
undetectable
5umwE-2p0lA:
undetectable		 5umwB-2p0lA:
12.37
5umwE-2p0lA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 2p0l LIPOATE-PROTEIN
LIGASE A
(Streptococcus
agalactiae) 		4 / 7 LEU A  49
VAL A 231
TYR A  19
GLU A 232
 None
 1.12A 5umwA-2p0lA:
undetectable
5umwF-2p0lA:
undetectable		 5umwA-2p0lA:
12.37
5umwF-2p0lA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2p0l LIPOATE-PROTEIN
LIGASE A
(Streptococcus
agalactiae) 		3 / 3 ARG A 168
PHE A 265
ARG A  38
 None
 1.21A 5y9yA-2p0lA:
undetectable		 5y9yA-2p0lA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2p0l LIPOATE-PROTEIN
LIGASE A
(Streptococcus
agalactiae) 		5 / 10 LEU A  67
ALA A  73
PRO A 211
GLU A 143
VAL A  58
 None
 1.47A 6b89A-2p0lA:
0.0		 6b89A-2p0lA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2p0l LIPOATE-PROTEIN
LIGASE A
(Streptococcus
agalactiae) 		5 / 10 LEU A  67
ALA A  73
PRO A 211
GLU A 145
VAL A  58
 None
 1.16A 6b89A-2p0lA:
0.0		 6b89A-2p0lA:
15.19