SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p0n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 2p0n HYPOTHETICAL PROTEIN
NMB1532
(Neisseria
meningitidis) 		3 / 3 ALA A 111
VAL A 106
TRP A 103
 None
 0.87A 1av2C-2p0nA:
undetectable
1av2D-2p0nA:
undetectable		 1av2C-2p0nA:
10.20
1av2D-2p0nA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 2p0n HYPOTHETICAL PROTEIN
NMB1532
(Neisseria
meningitidis) 		4 / 5 ARG A 166
ALA A 165
ASP A  69
GLY A 160
 None
 1.04A 1e7bA-2p0nA:
undetectable		 1e7bA-2p0nA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 2p0n HYPOTHETICAL PROTEIN
NMB1532
(Neisseria
meningitidis) 		5 / 12 PHE A  11
HIS A  96
LEU A  99
HIS A 136
LEU A  93
 None
MN  A 605 (-3.4A)
None
MN  A 605 ( 3.4A)
None
 1.23A 2hc4A-2p0nA:
undetectable		 2hc4A-2p0nA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 2p0n HYPOTHETICAL PROTEIN
NMB1532
(Neisseria
meningitidis) 		4 / 6 LEU A 137
GLU A 141
PRO A 142
ARG A  26
 None
 1.42A 3ltwA-2p0nA:
undetectable		 3ltwA-2p0nA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 2p0n HYPOTHETICAL PROTEIN
NMB1532
(Neisseria
meningitidis) 		4 / 5 LEU A 137
HIS A  96
GLU A  70
HIS A  67
 None
MN  A 605 (-3.4A)
MN  A 604 (-2.5A)
CL  A 608 (-4.4A)
 1.32A 4a7bB-2p0nA:
undetectable		 4a7bB-2p0nA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 2p0n HYPOTHETICAL PROTEIN
NMB1532
(Neisseria
meningitidis) 		5 / 12 ALA A  62
HIS A 136
GLU A 140
HIS A  96
TYR A 133
 BME  A 601 (-3.3A)
MN  A 605 ( 3.4A)
MN  A 605 (-2.4A)
MN  A 605 (-3.4A)
None
 1.46A 4r7lA-2p0nA:
undetectable		 4r7lA-2p0nA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 2p0n HYPOTHETICAL PROTEIN
NMB1532
(Neisseria
meningitidis) 		4 / 8 LEU A  78
GLU A  70
LEU A  18
LEU A 156
 None
MN  A 604 (-2.5A)
None
None
 1.16A 5dxeA-2p0nA:
undetectable		 5dxeA-2p0nA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 2p0n HYPOTHETICAL PROTEIN
NMB1532
(Neisseria
meningitidis) 		5 / 12 VAL A 130
ILE A  55
LEU A  49
CYH A  44
ALA A 111
 None
 1.18A 5fctB-2p0nA:
undetectable		 5fctB-2p0nA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_0
(REGULATORY PROTEIN
TETR)		 2p0n HYPOTHETICAL PROTEIN
NMB1532
(Neisseria
meningitidis) 		5 / 12 ALA A  56
SER A 107
GLU A 109
VAL A  32
CYH A  29
 None
 1.35A 5vlmH-2p0nA:
1.0		 5vlmH-2p0nA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2p0n HYPOTHETICAL PROTEIN
NMB1532
(Neisseria
meningitidis) 		4 / 8 LEU A  78
GLU A  70
LEU A  18
LEU A 156
 None
MN  A 604 (-2.5A)
None
None
 1.20A 6cbzA-2p0nA:
undetectable		 6cbzA-2p0nA:
20.71