SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p0r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2p0r CALPAIN-9
(Homo
sapiens) 		5 / 10 ILE A 103
ALA A 101
ASN A 109
ALA A 192
ILE A 117
 None
 1.11A 2aclC-2p0rA:
undetectable		 2aclC-2p0rA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 2p0r CALPAIN-9
(Homo
sapiens) 		4 / 7 GLN A  91
GLY A  95
HIS A 254
TRP A 280
 None
 0.44A 3ai8A-2p0rA:
7.4		 3ai8A-2p0rA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 2p0r CALPAIN-9
(Homo
sapiens) 		3 / 3 LEU A 100
TRP A  98
GLY A 189
 None
 0.65A 3l35A-2p0rA:
undetectable
3l35H-2p0rA:
undetectable		 3l35A-2p0rA:
8.79
3l35H-2p0rA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 2p0r CALPAIN-9
(Homo
sapiens) 		3 / 3 LEU A 100
TRP A  98
GLY A 189
 None
 0.74A 3l35B-2p0rA:
undetectable
3l35K-2p0rA:
undetectable		 3l35B-2p0rA:
8.79
3l35K-2p0rA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 2p0r CALPAIN-9
(Homo
sapiens) 		4 / 5 GLY A 315
ASP A 314
ARG A 275
MET A 196
 None
CA  A1002 (-3.0A)
None
None
 1.35A 3qx3A-2p0rA:
undetectable		 3qx3A-2p0rA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 2p0r CALPAIN-9
(Homo
sapiens) 		4 / 5 GLY A 315
ASP A 314
ARG A 275
MET A 196
 None
CA  A1002 (-3.0A)
None
None
 1.43A 3qx3B-2p0rA:
undetectable		 3qx3B-2p0rA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 2p0r CALPAIN-9
(Homo
sapiens) 		4 / 8 PHE A  79
PHE A 123
PHE A 133
ALA A 171
 None
 0.93A 3t3sF-2p0rA:
undetectable		 3t3sF-2p0rA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 2p0r CALPAIN-9
(Homo
sapiens) 		5 / 12 GLY A 231
ALA A 255
PHE A 328
VAL A 258
ILE A 274
 None
 0.98A 4uw0A-2p0rA:
undetectable		 4uw0A-2p0rA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2p0r CALPAIN-9
(Homo
sapiens) 		3 / 3 MET A  32
ASP A  47
PHE A  48
 None
 1.05A 4xeyA-2p0rA:
undetectable		 4xeyA-2p0rA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2p0r CALPAIN-9
(Homo
sapiens) 		3 / 3 MET A  32
ASP A  47
PHE A  48
 None
 1.03A 4xeyB-2p0rA:
undetectable		 4xeyB-2p0rA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2p0r CALPAIN-9
(Homo
sapiens) 		5 / 12 LEU A 229
GLY A 202
ASN A 335
ALA A 112
ASN A 109
 None
 1.40A 5kbwB-2p0rA:
undetectable		 5kbwB-2p0rA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_B_Z80B401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2p0r CALPAIN-9
(Homo
sapiens) 		5 / 9 ILE A 117
PHE A 133
THR A 107
ASP A  88
ILE A 103
 None
None
None
CA  A1003 (-2.3A)
None
 1.37A 5lg3B-2p0rA:
0.0		 5lg3B-2p0rA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_C_Z80C401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2p0r CALPAIN-9
(Homo
sapiens) 		5 / 9 ILE A 117
PHE A 133
THR A 107
ASP A  88
ILE A 103
 None
None
None
CA  A1003 (-2.3A)
None
 1.35A 5lg3C-2p0rA:
0.0		 5lg3C-2p0rA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_D_Z80D401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2p0r CALPAIN-9
(Homo
sapiens) 		5 / 9 ILE A 117
PHE A 133
THR A 107
ASP A  88
ILE A 103
 None
None
None
CA  A1003 (-2.3A)
None
 1.35A 5lg3D-2p0rA:
undetectable		 5lg3D-2p0rA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 2p0r CALPAIN-9
(Homo
sapiens) 		4 / 5 GLY A 315
ASP A 314
ARG A 275
MET A 196
 None
CA  A1002 (-3.0A)
None
None
 1.34A 5zrfB-2p0rA:
undetectable		 5zrfB-2p0rA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		 2p0r CALPAIN-9
(Homo
sapiens) 		4 / 4 GLY A 315
ASP A 314
ARG A 275
MET A 196
 None
CA  A1002 (-3.0A)
None
None
 1.28A 5zrfA-2p0rA:
undetectable		 5zrfA-2p0rA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2p0r CALPAIN-9
(Homo
sapiens) 		4 / 5 ARG A  20
LEU A 142
GLN A 134
PHE A 135
 None
 1.48A 6nmpP-2p0rA:
undetectable
6nmpW-2p0rA:
undetectable		 6nmpP-2p0rA:
20.94
6nmpW-2p0rA:
12.79