SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		4 / 5 HIS A 321
SER A 209
LEU A 123
GLY A 234
 None
 0.88A 1a4lB-2p0uA:
undetectable		 1a4lB-2p0uA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		5 / 11 LEU A 189
MET A 257
LEU A 402
VAL A 240
ILE A 254
 None
 1.22A 1ee2B-2p0uA:
undetectable		 1ee2B-2p0uA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		5 / 12 LEU A 372
SER A 371
LEU A 405
TYR A 255
ILE A 254
 None
 1.29A 1fmlA-2p0uA:
undetectable		 1fmlA-2p0uA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		4 / 8 THR A 150
GLY A 181
LEU A 281
GLY A 274
 None
 0.75A 1jhqA-2p0uA:
undetectable		 1jhqA-2p0uA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		4 / 5 LEU A 276
VAL A 282
ARG A 112
THR A 277
 None
 1.29A 1nw3A-2p0uA:
undetectable		 1nw3A-2p0uA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		5 / 10 LEU A 189
LEU A  38
VAL A 204
GLY A 243
ALA A 196
 None
 1.13A 1pxxA-2p0uA:
undetectable		 1pxxA-2p0uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		5 / 9 LEU A 189
LEU A  38
VAL A 204
GLY A 243
ALA A 196
 None
 1.13A 1pxxB-2p0uA:
undetectable		 1pxxB-2p0uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		5 / 10 LEU A 189
LEU A  38
VAL A 204
GLY A 243
ALA A 196
 None
 1.13A 1pxxD-2p0uA:
undetectable		 1pxxD-2p0uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		3 / 3 LYS A 125
ILE A 145
THR A 149
 None
 0.78A 1rx3A-2p0uA:
undetectable		 1rx3A-2p0uA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		5 / 12 ILE A 389
GLY A 323
ALA A 326
VAL A 360
SER A 359
 None
 1.13A 1sg9C-2p0uA:
undetectable		 1sg9C-2p0uA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		4 / 7 ASP A 235
ALA A 358
PHE A  88
THR A 215
 None
 1.06A 2q6oA-2p0uA:
undetectable		 2q6oA-2p0uA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		4 / 6 THR A 187
VAL A 188
GLU A 210
CYH A 208
 None
 1.14A 3b6rB-2p0uA:
undetectable		 3b6rB-2p0uA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		5 / 12 ALA A 237
GLY A 236
LEU A 361
SER A 359
MET A 355
 None
 1.33A 3bxoA-2p0uA:
undetectable		 3bxoA-2p0uA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		5 / 11 ALA A 186
ILE A 293
PRO A 290
LEU A 265
THR A 187
 None
 1.07A 3clbA-2p0uA:
undetectable		 3clbA-2p0uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		5 / 12 ALA A 186
ILE A 293
PRO A 290
LEU A 265
THR A 187
 None
 1.04A 3clbC-2p0uA:
undetectable		 3clbC-2p0uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		5 / 12 VAL A 360
LEU A 189
THR A 187
VAL A 188
VAL A 240
 None
 1.23A 3czvA-2p0uA:
undetectable
3czvB-2p0uA:
undetectable		 3czvA-2p0uA:
20.39
3czvB-2p0uA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		5 / 11 ALA A 186
ILE A 293
PRO A 290
LEU A 265
THR A 187
 None
 1.05A 3hbbC-2p0uA:
undetectable		 3hbbC-2p0uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		4 / 5 TYR A  54
ILE A 115
LEU A  90
PHE A  88
 None
 1.23A 3ls4L-2p0uA:
undetectable		 3ls4L-2p0uA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		4 / 5 PHE A 391
ILE A 293
GLY A 324
HIS A 321
 None
 1.31A 3r0lD-2p0uA:
undetectable		 3r0lD-2p0uA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		4 / 5 ASP A 329
LEU A 328
ILE A 293
PRO A 290
 None
 0.95A 3s3vA-2p0uA:
undetectable		 3s3vA-2p0uA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		3 / 3 PHE A 391
CYH A 182
HIS A 321
 None
 1.29A 3u9fF-2p0uA:
undetectable		 3u9fF-2p0uA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		3 / 3 PHE A 391
CYH A 182
HIS A 321
 None
 1.31A 3u9fL-2p0uA:
undetectable		 3u9fL-2p0uA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		3 / 3 PHE A 391
CYH A 182
HIS A 321
 None
 1.22A 3u9fS-2p0uA:
undetectable		 3u9fS-2p0uA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		3 / 3 LYS A 125
ILE A 145
THR A 149
 None
 0.80A 4gh8A-2p0uA:
undetectable		 4gh8A-2p0uA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		5 / 12 LEU A 232
CYH A 182
PHE A 391
GLY A 392
LEU A 285
 None
 1.31A 4ot2A-2p0uA:
undetectable		 4ot2A-2p0uA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		3 / 3 ASP A  79
LYS A  73
LEU A 227
 None
 1.08A 4ptjA-2p0uA:
undetectable		 4ptjA-2p0uA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		4 / 5 LEU A 364
VAL A 242
TYR A 255
ARG A 174
 None
 1.11A 4r7iA-2p0uA:
undetectable		 4r7iA-2p0uA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		4 / 5 PHE A 342
PRO A 322
VAL A 320
PHE A 391
 None
 1.15A 4w5oA-2p0uA:
undetectable		 4w5oA-2p0uA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		4 / 5 PHE A 342
PRO A 322
VAL A 320
PHE A 391
 None
 1.17A 4z4cA-2p0uA:
undetectable		 4z4cA-2p0uA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		4 / 5 PHE A 342
PRO A 322
VAL A 320
PHE A 391
 None
 1.17A 4z4dA-2p0uA:
undetectable		 4z4dA-2p0uA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		4 / 5 PHE A 342
PRO A 322
VAL A 320
PHE A 391
 None
 1.15A 4z4eA-2p0uA:
undetectable		 4z4eA-2p0uA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		5 / 12 LEU A 232
CYH A 182
PHE A 391
GLY A 392
LEU A 285
 None
 1.29A 4zbrA-2p0uA:
undetectable		 4zbrA-2p0uA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		5 / 11 ALA A 333
LEU A 328
ARG A 346
ILE A 293
GLY A 291
 None
 1.22A 5dxbB-2p0uA:
undetectable		 5dxbB-2p0uA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		4 / 8 ARG A 403
GLU A 256
GLY A  33
PRO A  34
 None
 0.94A 5kf8A-2p0uA:
undetectable		 5kf8A-2p0uA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		3 / 3 HIS A 284
ASP A 225
HIS A 223
 None
 0.89A 5n1tW-2p0uA:
undetectable		 5n1tW-2p0uA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		4 / 6 PHE A 342
PRO A 322
VAL A 320
PHE A 391
 None
 1.16A 5t7bA-2p0uA:
undetectable		 5t7bA-2p0uA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 2p0u STILBENECARBOXYLATE
SYNTHASE 2
(Marchantia
polymorpha) 		3 / 3 GLU A 197
ASP A 245
PRO A 246
 None
 0.28A 6berA-2p0uA:
undetectable		 6berA-2p0uA:
6.90