SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p0w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 2p0w HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 ILE A 114
LEU A  35
ILE A  33
THR A  85
ILE A 115
 None
 0.96A 2cd2A-2p0wA:
undetectable		 2cd2A-2p0wA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2p0w HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 5 LEU A 215
ALA A  80
ILE A  79
SER A  82
 None
 1.08A 2othA-2p0wA:
undetectable		 2othA-2p0wA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2p0w HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT
(Homo
sapiens) 		3 / 3 VAL A 229
LYS A 233
HIS A 261
 None
 0.94A 3elzA-2p0wA:
undetectable		 3elzA-2p0wA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 2p0w HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 9 GLY A 140
ALA A 164
ASP A 165
GLY A 170
LEU A 203
 ACM  A 803 (-3.7A)
None
ACM  A 803 ( 4.8A)
None
None
 1.03A 3ogpB-2p0wA:
undetectable		 3ogpB-2p0wA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 2p0w HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 GLY A 140
ALA A 164
ASP A 165
GLY A 170
LEU A 203
 ACM  A 803 (-3.7A)
None
ACM  A 803 ( 4.8A)
None
None
 0.98A 3ogqB-2p0wA:
undetectable		 3ogqB-2p0wA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 2p0w HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 178
SER A  84
GLU A 133
GLY A  81
THR A 218
 None
 1.23A 5o4yD-2p0wA:
undetectable
5o4yE-2p0wA:
undetectable		 5o4yD-2p0wA:
6.09
5o4yE-2p0wA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2p0w HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT
(Homo
sapiens) 		3 / 3 VAL A 219
VAL A 204
GLN A 160
 None
 0.71A 5qglA-2p0wA:
undetectable		 5qglA-2p0wA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2p0w HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT
(Homo
sapiens) 		3 / 3 VAL A 219
VAL A 204
GLN A 255
 None
 0.64A 5qgmA-2p0wA:
undetectable		 5qgmA-2p0wA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2p0w HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT
(Homo
sapiens) 		3 / 3 VAL A 219
VAL A 204
GLN A 160
 None
 0.71A 5qgvA-2p0wA:
undetectable		 5qgvA-2p0wA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGX_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2p0w HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT
(Homo
sapiens) 		3 / 3 VAL A 219
VAL A 204
GLN A 160
 None
 0.71A 5qgxA-2p0wA:
undetectable		 5qgxA-2p0wA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH1_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2p0w HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT
(Homo
sapiens) 		3 / 3 VAL A 219
VAL A 204
GLN A 160
 None
 0.71A 5qh1A-2p0wA:
undetectable		 5qh1A-2p0wA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH4_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2p0w HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT
(Homo
sapiens) 		3 / 3 VAL A 219
VAL A 204
GLN A 160
 None
 0.71A 5qh4A-2p0wA:
undetectable		 5qh4A-2p0wA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2p0w HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT
(Homo
sapiens) 		3 / 3 VAL A 219
VAL A 204
GLN A 160
 None
 0.69A 5qhgA-2p0wA:
undetectable		 5qhgA-2p0wA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2p0w HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 7 GLY A  61
PHE A  60
HIS A  57
LYS A 110
 None
 0.83A 6hu9S-2p0wA:
undetectable
6hu9q-2p0wA:
undetectable		 6hu9S-2p0wA:
13.66
6hu9q-2p0wA:
17.73