SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p10'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		4 / 7 ILE A  51
GLU A  43
ARG A  60
ALA A 258
 None
None
CL  A 290 (-2.9A)
CL  A 290 (-4.0A)
 1.17A 1oniD-2p10A:
undetectable
1oniE-2p10A:
undetectable		 1oniD-2p10A:
22.10
1oniE-2p10A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 8 VAL A  87
GLU A  86
MET A  83
SER A  39
ILE A  51
 None
 1.48A 1pk7B-2p10A:
undetectable		 1pk7B-2p10A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		4 / 7 GLU A 215
ALA A 220
PRO A 172
ALA A 175
 ACT  A 288 (-4.4A)
None
ACT  A 287 (-4.8A)
None
 1.06A 2ejfA-2p10A:
undetectable		 2ejfA-2p10A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		4 / 7 ILE A 185
CYH A 188
ILE A 245
LEU A 246
 None
 0.88A 2q83A-2p10A:
undetectable		 2q83A-2p10A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 10 ILE A 185
LEU A  70
THR A 129
ILE A  29
GLY A 233
 None
ACT  A 286 (-3.7A)
None
None
None
 1.25A 2v0mA-2p10A:
undetectable		 2v0mA-2p10A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 8 THR A  94
PRO A  95
VAL A  96
GLU A  43
ALA A  40
 None
 1.43A 2v32A-2p10A:
undetectable
2v32B-2p10A:
undetectable		 2v32A-2p10A:
21.74
2v32B-2p10A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 8 THR A  94
PRO A  95
VAL A  96
GLU A  43
ALA A  40
 None
 1.49A 2v32A-2p10A:
undetectable
2v32B-2p10A:
undetectable		 2v32A-2p10A:
21.74
2v32B-2p10A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_A_BEZA1222_0
(PEROXIREDOXIN 6.)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 9 THR A  94
PRO A  95
VAL A  96
GLU A  43
ALA A  40
 None
 1.48A 2v41A-2p10A:
undetectable
2v41B-2p10A:
undetectable		 2v41A-2p10A:
21.74
2v41B-2p10A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_B_BEZB1222_0
(PEROXIREDOXIN 6.)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 9 THR A  94
PRO A  95
VAL A  96
GLU A  43
ALA A  40
 None
 1.48A 2v41A-2p10A:
undetectable
2v41B-2p10A:
undetectable		 2v41A-2p10A:
21.74
2v41B-2p10A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 12 ASP A 174
ASN A 101
PHE A 127
GLY A  99
GLY A 131
 None
ACT  A 286 (-3.2A)
CL  A 290 ( 4.7A)
None
None
 1.35A 2y6rC-2p10A:
undetectable		 2y6rC-2p10A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		4 / 6 GLU A 215
ALA A 220
PRO A 172
ALA A 175
 ACT  A 288 (-4.4A)
None
ACT  A 287 (-4.8A)
None
 1.12A 2zgwB-2p10A:
undetectable		 2zgwB-2p10A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		3 / 3 LEU A  67
LEU A  70
ARG A 138
 None
ACT  A 286 (-3.7A)
None
 0.60A 3hcnB-2p10A:
undetectable		 3hcnB-2p10A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 12 GLY A  35
GLY A  46
ALA A  45
SER A  42
LEU A  38
 None
 0.99A 3hs6B-2p10A:
undetectable		 3hs6B-2p10A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 12 GLY A  33
ALA A 258
GLU A 262
ALA A  40
ILE A  53
 None
CL  A 290 (-4.0A)
None
None
None
 1.06A 3id6C-2p10A:
undetectable		 3id6C-2p10A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		4 / 8 ASN A 126
THR A 129
LEU A  70
SER A  56
 None
None
ACT  A 286 (-3.7A)
None
 1.11A 3kp2A-2p10A:
undetectable
3kp2B-2p10A:
undetectable		 3kp2A-2p10A:
19.30
3kp2B-2p10A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 11 VAL A  96
LEU A  97
LEU A  88
GLY A  33
ALA A  34
 None
 1.25A 3pghB-2p10A:
undetectable		 3pghB-2p10A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 12 GLU A 262
GLY A  33
ASP A  49
ILE A  48
GLY A 257
 None
None
None
None
CL  A 289 (-3.6A)
 1.28A 3ps9A-2p10A:
undetectable		 3ps9A-2p10A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 11 ASP A 174
ASN A 101
PHE A 127
GLY A  99
GLY A 131
 None
ACT  A 286 (-3.2A)
CL  A 290 ( 4.7A)
None
None
 1.21A 3v3oC-2p10A:
undetectable		 3v3oC-2p10A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 11 GLY A  31
ALA A 258
GLY A 257
VAL A  52
VAL A 187
 None
CL  A 290 (-4.0A)
CL  A 289 (-3.6A)
None
None
 1.27A 4c5lA-2p10A:
3.5		 4c5lA-2p10A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 9 GLY A  31
ALA A 258
GLY A 257
VAL A  52
VAL A 187
 None
CL  A 290 (-4.0A)
CL  A 289 (-3.6A)
None
None
 1.22A 4c5lB-2p10A:
undetectable		 4c5lB-2p10A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 10 GLY A  31
ALA A 258
GLY A 257
VAL A  52
VAL A 187
 None
CL  A 290 (-4.0A)
CL  A 289 (-3.6A)
None
None
 1.26A 4c5lC-2p10A:
3.4		 4c5lC-2p10A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 10 GLY A  31
ALA A 258
GLY A 257
VAL A  52
VAL A 187
 None
CL  A 290 (-4.0A)
CL  A 289 (-3.6A)
None
None
 1.17A 4c5lD-2p10A:
3.4		 4c5lD-2p10A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 10 GLY A  31
ALA A 258
GLY A 257
VAL A  52
VAL A 187
 None
CL  A 290 (-4.0A)
CL  A 289 (-3.6A)
None
None
 1.23A 4c5nB-2p10A:
2.9		 4c5nB-2p10A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 10 GLY A  31
ALA A 258
GLY A 257
VAL A  52
VAL A 187
 None
CL  A 290 (-4.0A)
CL  A 289 (-3.6A)
None
None
 1.28A 4c5nD-2p10A:
3.8		 4c5nD-2p10A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 9 VAL A  96
VAL A  80
ILE A  53
GLY A  33
ALA A  40
 None
 1.08A 4fwdA-2p10A:
undetectable		 4fwdA-2p10A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_1
(BIFUNCTIONAL AAC/APH)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 12 TYR A  54
GLY A  33
HIS A 232
TYR A 168
GLU A 262
 CL  A 290 (-4.8A)
None
CL  A 289 (-4.5A)
None
None
 1.32A 4qc6B-2p10A:
0.0		 4qc6B-2p10A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		4 / 7 ASN A 101
PRO A 128
PHE A 127
PHE A 121
 ACT  A 286 (-3.2A)
ACT  A 286 ( 4.4A)
CL  A 290 ( 4.7A)
None
 1.38A 4v32C-2p10A:
0.0		 4v32C-2p10A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 11 ALA A  98
VAL A  91
GLY A  32
GLY A  33
ALA A  34
 None
 0.76A 5lf7K-2p10A:
undetectable
5lf7L-2p10A:
undetectable		 5lf7K-2p10A:
23.45
5lf7L-2p10A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 2p10 MLL9387 PROTEIN
(Mesorhizobium
japonicum) 		5 / 11 ALA A  98
VAL A  91
GLY A  32
GLY A  33
ALA A  34
 None
 0.77A 5lf7Y-2p10A:
undetectable
5lf7Z-2p10A:
undetectable		 5lf7Y-2p10A:
23.45
5lf7Z-2p10A:
19.93