SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p11'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 2p11 HYPOTHETICAL PROTEIN
(Paraburkholderia
xenovorans) 		3 / 3 GLU A 148
HIS A 146
ASP A  16
 None
 0.85A 1i9gA-2p11A:
2.1		 1i9gA-2p11A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8F_A_DM1A127_1
(TRANSCRIPTIONAL
REGULATOR, PADR-LIKE
FAMILY)		 2p11 HYPOTHETICAL PROTEIN
(Paraburkholderia
xenovorans) 		5 / 10 ALA A 100
ALA A  93
PHE A  92
VAL A 137
ASP A  18
 None
None
None
None
GOL  A 232 (-3.7A)
 1.26A 3f8fA-2p11A:
undetectable
3f8fB-2p11A:
undetectable		 3f8fA-2p11A:
20.00
3f8fB-2p11A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 2p11 HYPOTHETICAL PROTEIN
(Paraburkholderia
xenovorans) 		4 / 5 ASP A 168
ASP A  16
ASP A 167
ARG A 171
 None
 1.29A 3naiC-2p11A:
undetectable		 3naiC-2p11A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 2p11 HYPOTHETICAL PROTEIN
(Paraburkholderia
xenovorans) 		4 / 7 ASP A 167
THR A 185
THR A  20
PHE A  15
 None
 1.01A 4ac9C-2p11A:
2.2		 4ac9C-2p11A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2p11 HYPOTHETICAL PROTEIN
(Paraburkholderia
xenovorans) 		4 / 6 ASP A 167
THR A 185
THR A  20
PHE A  15
 None
 0.95A 4acbC-2p11A:
3.3		 4acbC-2p11A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYS_B_VIBB501_1
(THIAMINE
PYRIDINYLASE I)		 2p11 HYPOTHETICAL PROTEIN
(Paraburkholderia
xenovorans) 		5 / 11 ASP A  16
TYR A 194
GLU A 200
ASP A 167
LEU A 170
 None
 1.44A 4kysB-2p11A:
0.0		 4kysB-2p11A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2p11 HYPOTHETICAL PROTEIN
(Paraburkholderia
xenovorans) 		4 / 6 ASN A  24
GLU A  52
LEU A  31
PHE A  51
 GOL  A 232 (-3.1A)
None
None
None
 1.07A 4twdB-2p11A:
undetectable
4twdC-2p11A:
undetectable		 4twdB-2p11A:
19.81
4twdC-2p11A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2p11 HYPOTHETICAL PROTEIN
(Paraburkholderia
xenovorans) 		4 / 6 ASN A  24
GLU A  52
LEU A  31
PHE A  51
 GOL  A 232 (-3.1A)
None
None
None
 1.04A 4twdD-2p11A:
undetectable
4twdE-2p11A:
undetectable		 4twdD-2p11A:
19.81
4twdE-2p11A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2p11 HYPOTHETICAL PROTEIN
(Paraburkholderia
xenovorans) 		4 / 6 ASN A  24
GLU A  52
LEU A  31
PHE A  51
 GOL  A 232 (-3.1A)
None
None
None
 1.25A 4twdI-2p11A:
undetectable
4twdJ-2p11A:
undetectable		 4twdI-2p11A:
19.81
4twdJ-2p11A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2p11 HYPOTHETICAL PROTEIN
(Paraburkholderia
xenovorans) 		3 / 3 TYR A 194
ARG A 171
LYS A 169
 None
 1.00A 4wq5B-2p11A:
undetectable		 4wq5B-2p11A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2p11 HYPOTHETICAL PROTEIN
(Paraburkholderia
xenovorans) 		5 / 12 ILE A 214
GLY A 215
ALA A 100
LEU A  21
VAL A  96
 None
 1.05A 5hw4A-2p11A:
2.3		 5hw4A-2p11A:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2p11 HYPOTHETICAL PROTEIN
(Paraburkholderia
xenovorans) 		5 / 11 ILE A 214
GLY A 215
ALA A 100
LEU A  21
VAL A  96
 None
 1.07A 5hw4B-2p11A:
2.7		 5hw4B-2p11A:
27.14