SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p12'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 2p12 HYPOTHETICAL PROTEIN
DUF402
(Rhodococcus
jostii) 		5 / 12 LEU A 105
GLY A  89
LEU A 117
THR A 143
ALA A 144
 None
 0.97A 2egvB-2p12A:
undetectable		 2egvB-2p12A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_A_C2FA1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 2p12 HYPOTHETICAL PROTEIN
DUF402
(Rhodococcus
jostii) 		5 / 11 THR A 143
LEU A 105
LEU A 123
HIS A 127
MET A 124
 None
 1.37A 2idkA-2p12A:
undetectable
2idkB-2p12A:
undetectable
2idkC-2p12A:
undetectable
2idkD-2p12A:
0.2		 2idkA-2p12A:
21.85
2idkB-2p12A:
21.85
2idkC-2p12A:
21.85
2idkD-2p12A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2p12 HYPOTHETICAL PROTEIN
DUF402
(Rhodococcus
jostii) 		3 / 3 ASP A 119
TYR A 104
LYS A  12
 None
 1.05A 2othA-2p12A:
undetectable		 2othA-2p12A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 2p12 HYPOTHETICAL PROTEIN
DUF402
(Rhodococcus
jostii) 		3 / 3 LEU A 123
HIS A 127
MET A 124
 None
 0.95A 3thrD-2p12A:
undetectable		 3thrD-2p12A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 2p12 HYPOTHETICAL PROTEIN
DUF402
(Rhodococcus
jostii) 		5 / 12 LEU A 123
HIS A 127
MET A 124
LEU A 105
THR A 143
 None
 1.46A 3thrA-2p12A:
undetectable
3thrB-2p12A:
undetectable
3thrC-2p12A:
undetectable
3thrD-2p12A:
0.0		 3thrA-2p12A:
21.85
3thrB-2p12A:
21.85
3thrC-2p12A:
21.85
3thrD-2p12A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 2p12 HYPOTHETICAL PROTEIN
DUF402
(Rhodococcus
jostii) 		4 / 8 LEU A  43
SER A  59
ASP A  34
PHE A  16
 None
 1.08A 4drjB-2p12A:
undetectable		 4drjB-2p12A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2p12 HYPOTHETICAL PROTEIN
DUF402
(Rhodococcus
jostii) 		5 / 9 ALA A 137
THR A 136
ALA A 140
GLY A 130
ALA A 126
 None
 1.12A 4qvnK-2p12A:
undetectable
4qvnL-2p12A:
undetectable		 4qvnK-2p12A:
20.47
4qvnL-2p12A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2p12 HYPOTHETICAL PROTEIN
DUF402
(Rhodococcus
jostii) 		5 / 9 ALA A 137
THR A 136
ALA A 140
GLY A 130
ALA A 126
 None
 1.12A 4qvnY-2p12A:
undetectable
4qvnZ-2p12A:
undetectable		 4qvnY-2p12A:
20.47
4qvnZ-2p12A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2p12 HYPOTHETICAL PROTEIN
DUF402
(Rhodococcus
jostii) 		6 / 10 ALA A 137
THR A 136
ALA A 140
THR A 128
GLY A 130
ALA A 126
 None
 1.14A 4qvpK-2p12A:
undetectable
4qvpL-2p12A:
undetectable		 4qvpK-2p12A:
20.47
4qvpL-2p12A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2p12 HYPOTHETICAL PROTEIN
DUF402
(Rhodococcus
jostii) 		6 / 10 ALA A 137
THR A 136
ALA A 140
THR A 128
GLY A 130
ALA A 126
 None
 1.14A 4qvpY-2p12A:
undetectable
4qvpZ-2p12A:
undetectable		 4qvpY-2p12A:
20.47
4qvpZ-2p12A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2p12 HYPOTHETICAL PROTEIN
DUF402
(Rhodococcus
jostii) 		5 / 9 ALA A 137
THR A 136
ALA A 140
GLY A 130
ALA A 126
 None
 1.10A 4qvqK-2p12A:
undetectable
4qvqL-2p12A:
undetectable		 4qvqK-2p12A:
20.47
4qvqL-2p12A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2p12 HYPOTHETICAL PROTEIN
DUF402
(Rhodococcus
jostii) 		5 / 9 ALA A 137
THR A 136
ALA A 140
GLY A 130
ALA A 126
 None
 1.10A 4qvqY-2p12A:
undetectable
4qvqZ-2p12A:
undetectable		 4qvqY-2p12A:
20.47
4qvqZ-2p12A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 2p12 HYPOTHETICAL PROTEIN
DUF402
(Rhodococcus
jostii) 		3 / 3 ARG A  68
ASN A  23
ASP A  50
 None
 0.87A 5gwxA-2p12A:
undetectable		 5gwxA-2p12A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2p12 HYPOTHETICAL PROTEIN
DUF402
(Rhodococcus
jostii) 		5 / 9 ALA A 137
THR A 136
ALA A 140
GLY A 130
ALA A 126
 None
 1.05A 5l5zK-2p12A:
undetectable
5l5zL-2p12A:
undetectable		 5l5zK-2p12A:
21.27
5l5zL-2p12A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2p12 HYPOTHETICAL PROTEIN
DUF402
(Rhodococcus
jostii) 		5 / 9 ALA A 137
THR A 136
ALA A 140
GLY A 130
ALA A 126
 None
 1.05A 5l5zY-2p12A:
undetectable
5l5zZ-2p12A:
undetectable		 5l5zY-2p12A:
21.27
5l5zZ-2p12A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2p12 HYPOTHETICAL PROTEIN
DUF402
(Rhodococcus
jostii) 		3 / 3 LYS A  12
PRO A  11
LYS A   8
 None
 1.30A 5y9yA-2p12A:
undetectable		 5y9yA-2p12A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 2p12 HYPOTHETICAL PROTEIN
DUF402
(Rhodococcus
jostii) 		4 / 6 ASN A  23
LEU A  57
SER A  49
PHE A  72
 None
None
ACY  A 601 (-2.5A)
GOL  A 603 (-4.0A)
 1.15A 6ekuA-2p12A:
undetectable		 6ekuA-2p12A:
12.91