SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p13'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 2p13 CBS DOMAIN
(Nitrosomonas
europaea) 		4 / 6 SER A 450
THR A 471
ASP A 446
TRP A 448
 None
 1.20A 1mxdA-2p13A:
undetectable		 1mxdA-2p13A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 2p13 CBS DOMAIN
(Nitrosomonas
europaea) 		3 / 3 TRP A 443
GLN A 489
THR A 442
 None
 0.93A 4m2xA-2p13A:
undetectable		 4m2xA-2p13A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2p13 CBS DOMAIN
(Nitrosomonas
europaea) 		5 / 12 ILE A 499
ALA A 486
GLY A 481
PHE A 480
GLY A 473
 None
 1.15A 5i71A-2p13A:
undetectable		 5i71A-2p13A:
12.78