SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p14'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 2p14 HETERODIMERIC
RESTRICTION
ENDONUCLEASE
R.BSPD6I SMALL
SUBUNIT
(Bacillus
sp.
D6) 		4 / 7 TYR A   8
VAL A 135
ILE A  72
GLY A 110
 None
 0.85A 11gsA-2p14A:
undetectable		 11gsA-2p14A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2p14 HETERODIMERIC
RESTRICTION
ENDONUCLEASE
R.BSPD6I SMALL
SUBUNIT
(Bacillus
sp.
D6) 		4 / 7 LEU A 145
PHE A 152
TYR A  65
LEU A 161
 None
 1.03A 2eikA-2p14A:
undetectable
2eikJ-2p14A:
undetectable		 2eikA-2p14A:
16.34
2eikJ-2p14A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2p14 HETERODIMERIC
RESTRICTION
ENDONUCLEASE
R.BSPD6I SMALL
SUBUNIT
(Bacillus
sp.
D6) 		4 / 8 TYR A   8
VAL A 135
ILE A  72
GLY A 110
 None
 0.89A 2gssA-2p14A:
undetectable		 2gssA-2p14A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2p14 HETERODIMERIC
RESTRICTION
ENDONUCLEASE
R.BSPD6I SMALL
SUBUNIT
(Bacillus
sp.
D6) 		4 / 8 TYR A   8
VAL A 135
ILE A  72
GLY A 110
 None
 0.89A 2gssB-2p14A:
undetectable		 2gssB-2p14A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2p14 HETERODIMERIC
RESTRICTION
ENDONUCLEASE
R.BSPD6I SMALL
SUBUNIT
(Bacillus
sp.
D6) 		5 / 12 VAL A 142
LEU A 161
LEU A 133
PHE A 138
ILE A  72
 None
 1.08A 2oipA-2p14A:
undetectable		 2oipA-2p14A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2p14 HETERODIMERIC
RESTRICTION
ENDONUCLEASE
R.BSPD6I SMALL
SUBUNIT
(Bacillus
sp.
D6) 		4 / 5 LEU A   5
GLN A 144
THR A 143
THR A  25
 None
 1.15A 2zj0B-2p14A:
3.0		 2zj0B-2p14A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p14 HETERODIMERIC
RESTRICTION
ENDONUCLEASE
R.BSPD6I SMALL
SUBUNIT
(Bacillus
sp.
D6) 		5 / 12 ILE A 113
ILE A  70
LEU A  94
VAL A  90
ILE A 121
 None
 0.97A 3adsB-2p14A:
undetectable		 3adsB-2p14A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2p14 HETERODIMERIC
RESTRICTION
ENDONUCLEASE
R.BSPD6I SMALL
SUBUNIT
(Bacillus
sp.
D6) 		5 / 12 VAL A 142
LEU A 161
LEU A 133
PHE A 138
ILE A  72
 None
 1.07A 3hj3D-2p14A:
2.6		 3hj3D-2p14A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 2p14 HETERODIMERIC
RESTRICTION
ENDONUCLEASE
R.BSPD6I SMALL
SUBUNIT
(Bacillus
sp.
D6) 		4 / 8 TYR A   8
VAL A 135
ILE A  72
GLY A 110
 None
 0.86A 3n9jA-2p14A:
undetectable		 3n9jA-2p14A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 2p14 HETERODIMERIC
RESTRICTION
ENDONUCLEASE
R.BSPD6I SMALL
SUBUNIT
(Bacillus
sp.
D6) 		4 / 7 VAL A 142
LEU A   5
TYR A   8
PHE A  29
 None
 0.92A 3qeoB-2p14A:
undetectable		 3qeoB-2p14A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2p14 HETERODIMERIC
RESTRICTION
ENDONUCLEASE
R.BSPD6I SMALL
SUBUNIT
(Bacillus
sp.
D6) 		3 / 3 TYR A  20
LEU A  32
LYS A  30
 None
None
GOL  A 195 ( 4.6A)
 0.75A 3sueD-2p14A:
undetectable		 3sueD-2p14A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2p14 HETERODIMERIC
RESTRICTION
ENDONUCLEASE
R.BSPD6I SMALL
SUBUNIT
(Bacillus
sp.
D6) 		4 / 8 HIS A  93
GLU A  73
ASP A  60
GLU A  22
 SO4  A 194 (-3.9A)
None
None
None
 1.12A 6mn4D-2p14A:
undetectable		 6mn4D-2p14A:
21.27