SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p17'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		5 / 10 ARG A 236
VAL A 167
VAL A  63
VAL A  88
LEU A 238
 None
 1.22A 1fe2A-2p17A:
undetectable		 1fe2A-2p17A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		4 / 6 HIS A  73
LEU A  83
LEU A  71
PRO A 103
 None
 1.32A 1hz4A-2p17A:
undetectable		 1hz4A-2p17A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		5 / 11 TYR A 240
GLU A  61
VAL A 116
PHE A  39
PHE A 191
 None
 1.12A 2dg4A-2p17A:
undetectable		 2dg4A-2p17A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		4 / 8 HIS A  73
HIS A  99
VAL A  97
THR A  62
 None
FE  A 278 (-3.1A)
None
None
 0.80A 2it4A-2p17A:
undetectable		 2it4A-2p17A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		3 / 3 ARG A 128
GLU A 126
THR A 125
 None
 0.82A 3v4tA-2p17A:
undetectable		 3v4tA-2p17A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		4 / 4 LEU A  28
LEU A 192
GLN A 113
GLU A  44
 None
 1.22A 4i41A-2p17A:
undetectable		 4i41A-2p17A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4G_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		4 / 7 THR A 161
LEU A 132
VAL A  88
VAL A 116
 None
 1.05A 4l4gA-2p17A:
undetectable		 4l4gA-2p17A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		3 / 3 ASP A 136
VAL A 149
ASN A 131
 None
 0.73A 4lmnA-2p17A:
undetectable		 4lmnA-2p17A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		4 / 5 GLY A 106
SER A 107
ALA A 104
GLU A  70
 None
 1.07A 4m93B-2p17A:
undetectable
4m93C-2p17A:
2.0		 4m93B-2p17A:
20.00
4m93C-2p17A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		4 / 8 LEU A 238
VAL A  88
LEU A 112
TYR A 240
 None
 1.01A 4puoC-2p17A:
undetectable		 4puoC-2p17A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		5 / 12 GLY A  84
GLY A  69
PRO A 103
LEU A  71
ARG A 148
 None
 1.31A 4x61A-2p17A:
undetectable		 4x61A-2p17A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		5 / 12 PHE A 216
ILE A   7
LEU A 235
THR A 146
MET A 172
 None
 1.12A 4zdyA-2p17A:
undetectable		 4zdyA-2p17A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		5 / 12 PHE A 216
ILE A   7
LEU A 235
THR A 146
MET A 172
 None
 1.13A 4ze2A-2p17A:
undetectable		 4ze2A-2p17A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		5 / 12 GLY A 242
GLY A  84
GLY A  86
LEU A 238
THR A 168
 None
 1.08A 5eqbA-2p17A:
undetectable		 5eqbA-2p17A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		4 / 8 PHE A 216
ILE A   7
LEU A 235
MET A 172
 None
 0.89A 5esjA-2p17A:
undetectable		 5esjA-2p17A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		3 / 3 MET A  15
HIS A 110
GLY A 211
 None
 0.67A 5gwzB-2p17A:
undetectable		 5gwzB-2p17A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		5 / 12 TYR A 240
GLU A  61
VAL A 116
PHE A  39
PHE A 191
 None
 1.17A 5hkgA-2p17A:
undetectable		 5hkgA-2p17A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		5 / 12 LEU A 227
LEU A 195
PHE A 191
ALA A 213
LEU A  42
 None
 1.12A 5iepA-2p17A:
undetectable		 5iepA-2p17A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		4 / 6 HIS A  73
HIS A  99
VAL A  97
THR A  62
 None
FE  A 278 (-3.1A)
None
None
 0.85A 5ogjA-2p17A:
undetectable		 5ogjA-2p17A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		4 / 6 HIS A  73
HIS A  99
VAL A  97
THR A  62
 None
FE  A 278 (-3.1A)
None
None
 0.83A 5ogjB-2p17A:
undetectable		 5ogjB-2p17A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		4 / 5 HIS A  73
HIS A  99
VAL A  97
THR A  62
 None
FE  A 278 (-3.1A)
None
None
 0.82A 5ohhA-2p17A:
undetectable		 5ohhA-2p17A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		4 / 6 HIS A  73
HIS A  99
VAL A  97
THR A  62
 None
FE  A 278 (-3.1A)
None
None
 0.84A 5ohhB-2p17A:
undetectable		 5ohhB-2p17A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		4 / 8 HIS A  73
HIS A  99
VAL A  97
THR A  62
 None
FE  A 278 (-3.1A)
None
None
 0.71A 5tt3F-2p17A:
undetectable		 5tt3F-2p17A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		4 / 7 SER A 153
THR A 168
HIS A 187
PRO A 185
 None
 1.21A 5vkqA-2p17A:
undetectable
5vkqB-2p17A:
undetectable		 5vkqA-2p17A:
10.35
5vkqB-2p17A:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		4 / 7 SER A 153
THR A 168
HIS A 187
PRO A 185
 None
 1.17A 5vkqC-2p17A:
undetectable
5vkqD-2p17A:
undetectable		 5vkqC-2p17A:
10.35
5vkqD-2p17A:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		5 / 12 PHE A 216
ILE A   7
LEU A 235
THR A 146
MET A 172
 None
 1.12A 6e8qA-2p17A:
undetectable		 6e8qA-2p17A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2p17 PIRIN-LIKE PROTEIN
(Geobacillus
kaustophilus) 		5 / 5 LEU A 184
TYR A 188
ILE A  60
MET A 169
GLY A 152
 None
 1.39A 6hd6A-2p17A:
undetectable		 6hd6A-2p17A:
16.32