SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p18'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		4 / 8 ASP A 109
PHE A 175
THR A 140
HIS A  78
 None
ACY  A1022 (-4.9A)
None
ZN  A 302 ( 3.2A)
 1.01A 1ei6C-2p18A:
undetectable		 1ei6C-2p18A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		4 / 8 ASN A 264
LEU A 265
TYR A 242
SER A 255
 None
 1.25A 1hk2A-2p18A:
undetectable		 1hk2A-2p18A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 11 PHE A 207
ILE A 206
ASN A 264
ASP A 164
GLY A 163
 None
None
None
ZN  A 301 (-2.5A)
None
 1.00A 1hvyC-2p18A:
undetectable		 1hvyC-2p18A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 VAL A 133
GLY A 121
ASN A 108
ALA A 107
ILE A 111
 None
 1.19A 1kxhA-2p18A:
undetectable		 1kxhA-2p18A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 10 GLU A 120
ALA A 185
LEU A 145
ALA A 136
GLY A 142
 None
 1.33A 1mjqG-2p18A:
undetectable
1mjqH-2p18A:
undetectable		 1mjqG-2p18A:
14.75
1mjqH-2p18A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		4 / 5 LEU A  88
ILE A  72
LEU A  73
SER A  74
 None
 0.77A 2byoA-2p18A:
undetectable		 2byoA-2p18A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 ASP A 135
ALA A 107
ILE A 111
SER A 110
ASP A 122
 None
 1.16A 2ejtA-2p18A:
undetectable		 2ejtA-2p18A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_A_BEZA500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 10 ASP A  80
HIS A 139
ASP A 164
PHE A 175
HIS A 210
 ZN  A 301 ( 2.7A)
ZN  A 302 ( 3.2A)
ZN  A 301 (-2.5A)
ACY  A1022 (-4.9A)
ZN  A 301 ( 3.3A)
 0.46A 2q0jA-2p18A:
14.3		 2q0jA-2p18A:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		6 / 11 ASP A  80
HIS A  81
HIS A 139
ASP A 164
PHE A 175
HIS A 210
 ZN  A 301 ( 2.7A)
ZN  A 301 (-3.3A)
ZN  A 302 ( 3.2A)
ZN  A 301 (-2.5A)
ACY  A1022 (-4.9A)
ZN  A 301 ( 3.3A)
 0.48A 2q0jB-2p18A:
14.5		 2q0jB-2p18A:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 LEU A 160
GLY A 163
GLY A 170
ILE A 171
ILE A 206
 None
 0.96A 2q63B-2p18A:
undetectable		 2q63B-2p18A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 LEU A 160
GLY A 163
GLY A 170
ILE A 171
ILE A 206
 None
 0.92A 2q64A-2p18A:
undetectable		 2q64A-2p18A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 LEU A 160
GLY A 163
GLY A 170
ILE A 171
ILE A 206
 None
 0.94A 2qakB-2p18A:
undetectable		 2qakB-2p18A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 10 GLY A 172
ALA A 173
HIS A 143
HIS A  76
HIS A  81
 SPD  A 304 ( 4.2A)
SPD  A 304 (-3.9A)
None
ZN  A 302 (-3.4A)
ZN  A 301 (-3.3A)
 1.27A 3boyA-2p18A:
0.0
3boyC-2p18A:
undetectable		 3boyA-2p18A:
18.06
3boyC-2p18A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 10 HIS A  76
HIS A  81
GLY A 172
ALA A 173
HIS A 143
 ZN  A 302 (-3.4A)
ZN  A 301 (-3.3A)
SPD  A 304 ( 4.2A)
SPD  A 304 (-3.9A)
None
 1.27A 3boyA-2p18A:
0.0
3boyB-2p18A:
undetectable		 3boyA-2p18A:
18.06
3boyB-2p18A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA3001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 10 HIS A  76
HIS A  81
GLY A 172
ALA A 173
HIS A 143
 ZN  A 302 (-3.4A)
ZN  A 301 (-3.3A)
SPD  A 304 ( 4.2A)
SPD  A 304 (-3.9A)
None
 1.27A 3boyB-2p18A:
undetectable
3boyC-2p18A:
undetectable		 3boyB-2p18A:
18.06
3boyC-2p18A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 9 ALA A 169
LEU A 257
PRO A 254
VAL A 253
ILE A 168
 None
 1.14A 3em4B-2p18A:
undetectable		 3em4B-2p18A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		3 / 3 ASN A 196
ASP A 201
ARG A 184
 None
 0.84A 3k13C-2p18A:
undetectable		 3k13C-2p18A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 LEU A 160
GLY A 163
GLY A 170
ILE A 171
ILE A 206
 None
 1.06A 3mwsA-2p18A:
undetectable		 3mwsA-2p18A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 LEU A 160
GLY A 163
GLY A 170
ILE A 171
ILE A 206
 None
 0.96A 3ndtC-2p18A:
undetectable		 3ndtC-2p18A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 LEU A 160
GLY A 163
GLY A 170
ILE A 171
ILE A 206
 None
 0.98A 3nduC-2p18A:
undetectable		 3nduC-2p18A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		3 / 3 TYR A 190
ASP A 201
ASP A 197
 None
 0.98A 3ou7B-2p18A:
undetectable		 3ou7B-2p18A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 HIS A 210
GLY A 209
ASP A  80
GLY A 172
PHE A 175
 ZN  A 301 ( 3.3A)
None
ZN  A 301 ( 2.7A)
SPD  A 304 ( 4.2A)
ACY  A1022 (-4.9A)
 1.13A 3sudB-2p18A:
undetectable		 3sudB-2p18A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		4 / 5 ASP A 201
THR A 204
LEU A 257
LYS A 261
 None
 1.21A 4a3pA-2p18A:
undetectable		 4a3pA-2p18A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 10 HIS A  76
HIS A  78
ASP A  80
HIS A 139
HIS A 210
 ZN  A 302 (-3.4A)
ZN  A 302 ( 3.2A)
ZN  A 301 ( 2.7A)
ZN  A 302 ( 3.2A)
ZN  A 301 ( 3.3A)
 0.68A 4c1dB-2p18A:
15.7		 4c1dB-2p18A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 11 HIS A  76
HIS A  78
ASP A  80
HIS A 139
HIS A 210
 ZN  A 302 (-3.4A)
ZN  A 302 ( 3.2A)
ZN  A 301 ( 2.7A)
ZN  A 302 ( 3.2A)
ZN  A 301 ( 3.3A)
 0.72A 4c1fA-2p18A:
3.1
4c1fB-2p18A:
3.2		 4c1fA-2p18A:
23.99
4c1fB-2p18A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 9 HIS A  76
HIS A  78
ASP A  80
HIS A 139
HIS A 210
 ZN  A 302 (-3.4A)
ZN  A 302 ( 3.2A)
ZN  A 301 ( 2.7A)
ZN  A 302 ( 3.2A)
ZN  A 301 ( 3.3A)
 0.67A 4c1hA-2p18A:
16.4		 4c1hA-2p18A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 9 HIS A  78
ASP A  80
HIS A  76
GLY A 172
HIS A 210
 ZN  A 302 ( 3.2A)
ZN  A 301 ( 2.7A)
ZN  A 302 (-3.4A)
SPD  A 304 ( 4.2A)
ZN  A 301 ( 3.3A)
 1.04A 4c1hA-2p18A:
16.4		 4c1hA-2p18A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		4 / 8 HIS A  78
ASP A  80
HIS A 139
HIS A 210
 ZN  A 302 ( 3.2A)
ZN  A 301 ( 2.7A)
ZN  A 302 ( 3.2A)
ZN  A 301 ( 3.3A)
 0.66A 4exsB-2p18A:
3.9		 4exsB-2p18A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 ILE A 192
ILE A 206
THR A 204
GLU A 132
THR A 162
 None
 1.00A 4jksA-2p18A:
undetectable		 4jksA-2p18A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 ILE A 192
ILE A 206
THR A 204
GLU A 132
THR A 162
 None
 0.99A 4jksB-2p18A:
undetectable		 4jksB-2p18A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 ILE A 192
ILE A 206
THR A 204
GLU A 132
THR A 162
 None
 0.98A 4jkuA-2p18A:
undetectable		 4jkuA-2p18A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 ILE A 192
ILE A 206
THR A 204
GLU A 132
THR A 162
 None
 0.98A 4k8cA-2p18A:
undetectable		 4k8cA-2p18A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 ILE A 192
ILE A 206
THR A 204
GLU A 132
THR A 162
 None
 0.99A 4k8cB-2p18A:
undetectable		 4k8cB-2p18A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 ILE A 192
ILE A 206
THR A 204
GLU A 132
THR A 162
 None
 0.99A 4k8kA-2p18A:
undetectable		 4k8kA-2p18A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 ILE A 192
ILE A 206
THR A 204
GLU A 132
THR A 162
 None
 1.00A 4k8kB-2p18A:
undetectable		 4k8kB-2p18A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 ILE A 192
ILE A 206
THR A 204
GLU A 132
THR A 162
 None
 0.99A 4kahA-2p18A:
undetectable		 4kahA-2p18A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 ILE A 192
ILE A 206
THR A 204
GLU A 132
THR A 162
 None
 0.98A 4kahB-2p18A:
undetectable		 4kahB-2p18A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 ILE A 192
ILE A 206
THR A 204
GLU A 132
THR A 162
 None
 1.01A 4kalA-2p18A:
undetectable		 4kalA-2p18A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 ILE A 192
ILE A 206
THR A 204
GLU A 132
THR A 162
 None
 0.99A 4kalB-2p18A:
undetectable		 4kalB-2p18A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 ILE A 192
ILE A 206
THR A 204
GLU A 132
THR A 162
 None
 0.99A 4kanA-2p18A:
undetectable		 4kanA-2p18A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 ILE A 192
ILE A 206
THR A 204
GLU A 132
THR A 162
 None
 0.98A 4kanB-2p18A:
undetectable		 4kanB-2p18A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 ILE A 192
ILE A 206
THR A 204
GLU A 132
THR A 162
 None
 0.98A 4kbeA-2p18A:
undetectable		 4kbeA-2p18A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 ILE A 192
ILE A 206
THR A 204
GLU A 132
THR A 162
 None
 0.99A 4kbeB-2p18A:
undetectable		 4kbeB-2p18A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 ILE A 192
ILE A 206
THR A 204
GLU A 132
THR A 162
 None
 0.98A 4lbgA-2p18A:
undetectable		 4lbgA-2p18A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 ILE A 192
ILE A 206
THR A 204
GLU A 132
THR A 162
 None
 0.98A 4lbgB-2p18A:
undetectable		 4lbgB-2p18A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 ILE A 192
ILE A 206
THR A 204
GLU A 132
THR A 162
 None
 0.98A 4lcaA-2p18A:
undetectable		 4lcaA-2p18A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 ILE A 192
ILE A 206
THR A 204
GLU A 132
THR A 162
 None
 1.00A 4lcaB-2p18A:
undetectable		 4lcaB-2p18A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_B_QELB920_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 10 TYR A 146
THR A 162
ALA A 136
ILE A 134
GLU A 176
 None
 1.32A 4pe5A-2p18A:
undetectable
4pe5B-2p18A:
1.1		 4pe5A-2p18A:
17.41
4pe5B-2p18A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_C_QELC939_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 10 TYR A 146
THR A 162
ALA A 136
ILE A 134
GLU A 176
 None
 1.29A 4pe5C-2p18A:
undetectable
4pe5D-2p18A:
undetectable		 4pe5C-2p18A:
17.41
4pe5D-2p18A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		4 / 8 HIS A  78
ASP A  80
HIS A 139
HIS A 210
 ZN  A 302 ( 3.2A)
ZN  A 301 ( 2.7A)
ZN  A 302 ( 3.2A)
ZN  A 301 ( 3.3A)
 0.69A 5a5zA-2p18A:
16.2		 5a5zA-2p18A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		6 / 11 HIS A  76
HIS A  78
ASP A  80
HIS A  81
HIS A 139
HIS A 210
 ZN  A 302 (-3.4A)
ZN  A 302 ( 3.2A)
ZN  A 301 ( 2.7A)
ZN  A 301 (-3.3A)
ZN  A 302 ( 3.2A)
ZN  A 301 ( 3.3A)
 0.29A 5ayaA-2p18A:
16.1		 5ayaA-2p18A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		4 / 6 THR A  75
VAL A 144
TYR A 146
HIS A  81
 None
None
None
ZN  A 301 (-3.3A)
 1.00A 5ecoA-2p18A:
undetectable		 5ecoA-2p18A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		4 / 5 LEU A 145
GLY A 163
ASP A 109
ILE A 111
 None
 1.01A 5ik1A-2p18A:
undetectable		 5ik1A-2p18A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 11 LEU A 160
ALA A 136
GLY A 172
ILE A 171
PRO A 208
 None
None
SPD  A 304 ( 4.2A)
None
None
 1.21A 5kr2B-2p18A:
undetectable		 5kr2B-2p18A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 LEU A 129
HIS A 150
ASP A  31
THR A  34
GLY A  10
 None
 1.43A 5m5kB-2p18A:
undetectable		 5m5kB-2p18A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		4 / 8 ASP A 164
HIS A 139
HIS A  76
HIS A 210
 ZN  A 301 (-2.5A)
ZN  A 302 ( 3.2A)
ZN  A 302 (-3.4A)
ZN  A 301 ( 3.3A)
 0.91A 5nekD-2p18A:
undetectable		 5nekD-2p18A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 10 HIS A  76
HIS A  78
HIS A  81
HIS A 139
ASP A 164
 ZN  A 302 (-3.4A)
ZN  A 302 ( 3.2A)
ZN  A 301 (-3.3A)
ZN  A 302 ( 3.2A)
ZN  A 301 (-2.5A)
 0.31A 5nzwA-2p18A:
6.0		 5nzwA-2p18A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UH6_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 ASP A 164
HIS A 143
ASN A  85
ILE A 111
HIS A 210
 ZN  A 301 (-2.5A)
None
None
None
ZN  A 301 ( 3.3A)
 1.49A 5uh6C-2p18A:
0.3		 5uh6C-2p18A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		4 / 6 PHE A 207
ILE A 206
ASP A 164
GLY A 163
 None
None
ZN  A 301 (-2.5A)
None
 0.94A 5x5qE-2p18A:
undetectable		 5x5qE-2p18A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		4 / 8 HIS A  78
ASP A  80
HIS A 139
HIS A 210
 ZN  A 302 ( 3.2A)
ZN  A 301 ( 2.7A)
ZN  A 302 ( 3.2A)
ZN  A 301 ( 3.3A)
 0.71A 5zj8A-2p18A:
16.3		 5zj8A-2p18A:
22.22