SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p1f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE
(Homo
sapiens) 		3 / 3 ILE A 257
ILE A 259
THR A  63
 None
 0.62A 1rg7A-2p1fA:
undetectable		 1rg7A-2p1fA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 6 LEU A  65
TYR A 277
ILE A 264
GLY A 229
 None
 0.83A 2du8A-2p1fA:
undetectable		 2du8A-2p1fA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 6 LEU A  65
TYR A 277
ILE A 264
GLY A 229
 None
 0.86A 2du8B-2p1fA:
undetectable		 2du8B-2p1fA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 5 LEU A  91
ASP A 149
LEU A  78
HIS A 116
 None
None
None
CSX  A 115 ( 3.9A)
 1.31A 2jfaA-2p1fA:
undetectable		 2jfaA-2p1fA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 11 LEU A  84
LEU A 109
ARG A 270
ILE A 264
VAL A  71
 None
 1.19A 2qd3A-2p1fA:
undetectable		 2qd3A-2p1fA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 6 ILE A 250
MET A  58
ILE A 257
HIS A 225
 None
 1.21A 3eteA-2p1fA:
undetectable
3eteE-2p1fA:
undetectable		 3eteA-2p1fA:
23.35
3eteE-2p1fA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 5 ILE A 250
MET A  58
ILE A 257
HIS A 225
 None
 1.22A 3eteB-2p1fA:
undetectable
3eteC-2p1fA:
undetectable		 3eteB-2p1fA:
23.35
3eteC-2p1fA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 12 GLU A 202
GLY A 210
ALA A 201
SER A 205
ALA A  51
 None
 1.13A 3nmuA-2p1fA:
undetectable
3nmuF-2p1fA:
undetectable		 3nmuA-2p1fA:
22.88
3nmuF-2p1fA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE
(Homo
sapiens) 		3 / 3 ASP A  96
ARG A 124
ASP A  70
 None
None
GOL  A2000 (-2.9A)
 0.86A 4fp9A-2p1fA:
undetectable		 4fp9A-2p1fA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A 113
LEU A 109
THR A  93
GLY A  85
PRO A  86
 None
 1.20A 4ypmA-2p1fA:
undetectable		 4ypmA-2p1fA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 5 ILE A  47
PHE A 223
SER A 205
ALA A  51
 None
 1.11A 5msdA-2p1fA:
2.5		 5msdA-2p1fA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 4 VAL A  50
LEU A  54
LEU A  55
ASP A 256
 None
 1.34A 5xv7A-2p1fA:
undetectable		 5xv7A-2p1fA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE
(Homo
sapiens) 		3 / 3 ASP A 100
ASP A  96
ASN A 152
 None
 0.85A 6gngB-2p1fA:
2.2		 6gngB-2p1fA:
20.39