SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p1g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 2p1g PUTATIVE XYLANASE
(Bacteroides
fragilis) 		4 / 8 SER A  28
LEU A  27
ILE A 194
ILE A 211
 None
 0.95A 1sbrA-2p1gA:
undetectable		 1sbrA-2p1gA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2p1g PUTATIVE XYLANASE
(Bacteroides
fragilis) 		4 / 8 ILE A 211
MET A 256
LEU A  72
GLY A  30
 None
 0.92A 2qqdB-2p1gA:
undetectable
2qqdC-2p1gA:
undetectable		 2qqdB-2p1gA:
19.09
2qqdC-2p1gA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 2p1g PUTATIVE XYLANASE
(Bacteroides
fragilis) 		6 / 12 LEU A 197
ALA A 212
ASP A 193
VAL A 253
GLY A 185
ILE A 195
 None
 1.19A 3k4vB-2p1gA:
undetectable		 3k4vB-2p1gA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2p1g PUTATIVE XYLANASE
(Bacteroides
fragilis) 		4 / 4 GLY A  41
GLU A  44
ASP A  46
ASP A  59
 None
 1.29A 3mb5A-2p1gA:
undetectable		 3mb5A-2p1gA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 2p1g PUTATIVE XYLANASE
(Bacteroides
fragilis) 		4 / 4 LEU A 186
GLY A 185
LEU A 181
GLU A 182
 None
 1.07A 3tgvB-2p1gA:
undetectable		 3tgvB-2p1gA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2p1g PUTATIVE XYLANASE
(Bacteroides
fragilis) 		4 / 8 TYR A  38
PHE A  63
VAL A  64
HIS A 208
 None
 0.52A 4eyzA-2p1gA:
8.1		 4eyzA-2p1gA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2p1g PUTATIVE XYLANASE
(Bacteroides
fragilis) 		4 / 8 TYR A  38
PHE A  63
VAL A  64
HIS A 208
 None
 0.50A 4eyzB-2p1gA:
8.1		 4eyzB-2p1gA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 2p1g PUTATIVE XYLANASE
(Bacteroides
fragilis) 		5 / 12 HIS A 208
ILE A 195
LEU A 186
LEU A 242
GLY A 250
 None
 1.16A 4foxB-2p1gA:
undetectable		 4foxB-2p1gA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2p1g PUTATIVE XYLANASE
(Bacteroides
fragilis) 		3 / 3 ILE A 195
MET A 241
ARG A 245
 None
 0.91A 4lnwA-2p1gA:
undetectable		 4lnwA-2p1gA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2p1g PUTATIVE XYLANASE
(Bacteroides
fragilis) 		3 / 3 ILE A 195
MET A 241
ARG A 245
 None
 0.90A 4lnxA-2p1gA:
undetectable		 4lnxA-2p1gA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 2p1g PUTATIVE XYLANASE
(Bacteroides
fragilis) 		5 / 10 LEU A 197
ALA A 212
VAL A 253
GLY A 185
ILE A 195
 None
 1.09A 4njuB-2p1gA:
undetectable		 4njuB-2p1gA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 2p1g PUTATIVE XYLANASE
(Bacteroides
fragilis) 		5 / 10 LEU A 197
ALA A 212
VAL A 253
GLY A 185
ILE A 195
 None
 1.08A 4njuD-2p1gA:
undetectable		 4njuD-2p1gA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2p1g PUTATIVE XYLANASE
(Bacteroides
fragilis) 		5 / 12 GLY A 210
TYR A 148
GLY A 203
THR A 201
HIS A 208
 None
 1.24A 5eslA-2p1gA:
undetectable		 5eslA-2p1gA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 2p1g PUTATIVE XYLANASE
(Bacteroides
fragilis) 		4 / 8 GLY A 185
TRP A 188
ASP A 193
ARG A 255
 None
 0.89A 5gqbA-2p1gA:
undetectable		 5gqbA-2p1gA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2p1g PUTATIVE XYLANASE
(Bacteroides
fragilis) 		5 / 9 LEU A 238
SER A 239
ILE A 189
VAL A 253
ILE A 251
 None
 1.14A 6ef6A-2p1gA:
undetectable		 6ef6A-2p1gA:
22.19