SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p1i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		4 / 7 THR A 136
ASN A 143
TYR A 144
LEU A  92
 None
 1.09A 1qzrB-2p1iA:
undetectable		 1qzrB-2p1iA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		5 / 11 GLU A 130
HIS A 133
GLU A 192
PHE A 200
GLU A 226
 FE  A 350 (-3.1A)
None
FE  A 350 (-2.2A)
None
FE  A 350 (-1.9A)
 0.94A 1rnrA-2p1iA:
26.4		 1rnrA-2p1iA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		5 / 11 HIS A 133
GLU A 192
PHE A 200
ILE A 222
GLU A 226
 None
FE  A 350 (-2.2A)
None
None
FE  A 350 (-1.9A)
 0.57A 1rnrA-2p1iA:
26.4		 1rnrA-2p1iA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		6 / 12 GLU A 130
HIS A 133
GLU A 192
PHE A 200
ILE A 222
GLU A 226
 FE  A 350 (-3.1A)
None
FE  A 350 (-2.2A)
None
None
FE  A 350 (-1.9A)
 0.86A 1rnrB-2p1iA:
26.4		 1rnrB-2p1iA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		6 / 12 HIS A 133
TYR A 137
GLU A 192
PHE A 200
ILE A 222
GLU A 226
 None
None
FE  A 350 (-2.2A)
None
None
FE  A 350 (-1.9A)
 0.80A 1rnrB-2p1iA:
26.4		 1rnrB-2p1iA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		3 / 3 MET A 275
GLU A  84
ASP A  76
 None
 1.06A 3a25A-2p1iA:
undetectable		 3a25A-2p1iA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		5 / 12 LEU A 212
PHE A 206
ILE A  88
PHE A  94
SER A 223
 None
 1.39A 3ko0G-2p1iA:
undetectable
3ko0H-2p1iA:
undetectable
3ko0I-2p1iA:
undetectable
3ko0J-2p1iA:
undetectable		 3ko0G-2p1iA:
15.88
3ko0H-2p1iA:
15.88
3ko0I-2p1iA:
15.88
3ko0J-2p1iA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		4 / 8 ARG A 261
ALA A 288
LEU A 292
SER A 303
 None
 0.94A 3qj7A-2p1iA:
undetectable
3qj7D-2p1iA:
undetectable		 3qj7A-2p1iA:
22.15
3qj7D-2p1iA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		5 / 12 PHE A 204
SER A 218
HIS A 133
TYR A 137
LEU A  92
 None
 1.29A 3vn2A-2p1iA:
undetectable		 3vn2A-2p1iA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		5 / 12 ILE A 236
ASN A 233
GLU A 104
GLU A 226
VAL A 114
 None
None
None
FE  A 350 (-1.9A)
None
 1.10A 4a97A-2p1iA:
1.4
4a97B-2p1iA:
2.2		 4a97A-2p1iA:
21.56
4a97B-2p1iA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		5 / 12 ALA A 119
VAL A  51
LEU A 239
PHE A 232
ILE A 185
 None
 1.20A 4pd5A-2p1iA:
undetectable		 4pd5A-2p1iA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		4 / 8 MET A 280
PHE A 204
TRP A 309
TRP A 205
 None
 1.45A 4v2zB-2p1iA:
undetectable		 4v2zB-2p1iA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		4 / 8 MET A 280
PHE A 204
TRP A 309
TRP A 205
 None
 1.44A 4v30B-2p1iA:
undetectable		 4v30B-2p1iA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		5 / 12 SER A 218
PHE A 206
LEU A  92
LEU A 140
TYR A 144
 None
 1.19A 4xumA-2p1iA:
undetectable		 4xumA-2p1iA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSG_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		5 / 9 GLU A 130
VAL A 129
GLY A 227
LEU A 228
THR A 230
 FE  A 350 (-3.1A)
None
None
None
None
 1.40A 5ksgB-2p1iA:
0.0		 5ksgB-2p1iA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_A_NIZA809_1
(CATALASE-PEROXIDASE)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		5 / 9 GLU A 130
VAL A 129
GLY A 227
LEU A 228
THR A 230
 FE  A 350 (-3.1A)
None
None
None
None
 1.43A 5ksnA-2p1iA:
0.0		 5ksnA-2p1iA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		5 / 9 GLU A 130
VAL A 129
GLY A 227
LEU A 228
THR A 230
 FE  A 350 (-3.1A)
None
None
None
None
 1.41A 5ksnB-2p1iA:
undetectable		 5ksnB-2p1iA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KT8_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		5 / 9 GLU A 130
VAL A 129
GLY A 227
LEU A 228
THR A 230
 FE  A 350 (-3.1A)
None
None
None
None
 1.39A 5kt8B-2p1iA:
undetectable		 5kt8B-2p1iA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		5 / 8 GLU A 130
VAL A 129
GLY A 227
LEU A 228
THR A 230
 FE  A 350 (-3.1A)
None
None
None
None
 1.43A 5sxqA-2p1iA:
undetectable		 5sxqA-2p1iA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXS_B_NIZB806_1
(CATALASE-PEROXIDASE)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		5 / 9 GLU A 130
VAL A 129
GLY A 227
LEU A 228
THR A 230
 FE  A 350 (-3.1A)
None
None
None
None
 1.40A 5sxsB-2p1iA:
undetectable		 5sxsB-2p1iA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		5 / 8 GLU A 130
VAL A 129
GLY A 227
LEU A 228
THR A 230
 FE  A 350 (-3.1A)
None
None
None
None
 1.38A 5sxtA-2p1iA:
undetectable		 5sxtA-2p1iA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		5 / 8 GLU A 130
VAL A 129
GLY A 227
LEU A 228
THR A 230
 FE  A 350 (-3.1A)
None
None
None
None
 1.38A 5sxtB-2p1iA:
undetectable		 5sxtB-2p1iA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_B_NIZB805_1
(CATALASE-PEROXIDASE)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		5 / 9 GLU A 130
VAL A 129
GLY A 227
LEU A 228
THR A 230
 FE  A 350 (-3.1A)
None
None
None
None
 1.40A 5syiB-2p1iA:
0.5		 5syiB-2p1iA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		5 / 8 GLU A 130
VAL A 129
GLY A 227
LEU A 228
THR A 230
 FE  A 350 (-3.1A)
None
None
None
None
 1.41A 5syjB-2p1iA:
undetectable		 5syjB-2p1iA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDQ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		5 / 9 GLU A 130
VAL A 129
GLY A 227
LEU A 228
THR A 230
 FE  A 350 (-3.1A)
None
None
None
None
 1.41A 6cdqA-2p1iA:
undetectable		 6cdqA-2p1iA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		5 / 9 GLU A 130
VAL A 129
GLY A 227
LEU A 228
THR A 230
 FE  A 350 (-3.1A)
None
None
None
None
 1.40A 6cdqB-2p1iA:
0.2		 6cdqB-2p1iA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CFQ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN
(Plasmodium
yoelii) 		5 / 9 GLU A 130
VAL A 129
GLY A 227
LEU A 228
THR A 230
 FE  A 350 (-3.1A)
None
None
None
None
 1.41A 6cfqB-2p1iA:
undetectable		 6cfqB-2p1iA:
12.50