SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p1r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 12 ILE A 264
LEU A 268
PHE A 266
ILE A 280
ILE A 258
 None
 0.99A 1drbB-2p1rA:
undetectable		 1drbB-2p1rA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 12 ARG A 290
GLY A  89
LEU A  88
ALA A 103
PHE A  99
 None
 1.14A 1gseA-2p1rA:
1.8		 1gseA-2p1rA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 11 GLY A  13
THR A  40
GLY A  68
ALA A  63
ILE A  70
 None
None
None
None
NA  A 300 (-4.9A)
 1.12A 1utdL-2p1rA:
2.2
1utdV-2p1rA:
2.3		 1utdL-2p1rA:
13.38
1utdV-2p1rA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 12 GLY A 205
GLY A 206
GLY A 207
LEU A 210
ASN A 137
 None
 1.10A 1xdsA-2p1rA:
2.0		 1xdsA-2p1rA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 12 GLY A 205
GLY A 206
GLY A 207
LEU A 210
ASN A 137
 None
 1.10A 1xdsB-2p1rA:
2.0		 1xdsB-2p1rA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		4 / 8 SER A 274
THR A 140
LEU A 231
THR A 133
 None
 1.20A 2v0zO-2p1rA:
undetectable		 2v0zO-2p1rA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		4 / 7 PRO A  92
ALA A 112
LEU A 109
ALA A  24
 None
 1.14A 2vcvA-2p1rA:
undetectable		 2vcvA-2p1rA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 9 PRO A  92
LEU A  93
ALA A 112
LEU A 109
ALA A  24
 None
 1.22A 2vcvD-2p1rA:
undetectable		 2vcvD-2p1rA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 9 PRO A  92
LEU A  93
ALA A 112
LEU A 109
ALA A  24
 None
 1.19A 2vcvE-2p1rA:
undetectable		 2vcvE-2p1rA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 9 PRO A  92
LEU A  93
ALA A 112
LEU A 109
ALA A  24
 None
 1.29A 2vcvH-2p1rA:
1.8		 2vcvH-2p1rA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 9 PRO A  92
LEU A  93
ALA A 112
LEU A 109
ALA A  24
 None
 1.14A 2vcvI-2p1rA:
undetectable		 2vcvI-2p1rA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		3 / 3 GLU A 281
ASP A 257
ASP A 131
 None
 0.65A 3jb2A-2p1rA:
undetectable		 3jb2A-2p1rA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 12 ASN A 137
ASP A  98
GLY A 270
ASN A 267
PHE A 266
 None
 1.25A 3k13C-2p1rA:
undetectable		 3k13C-2p1rA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 12 LEU A 169
GLY A  68
ASP A 269
VAL A  73
ALA A  96
 None
 0.84A 3ku1G-2p1rA:
undetectable		 3ku1G-2p1rA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 12 LEU A 169
GLY A  68
ASP A 269
VAL A  73
ALA A  96
 None
 0.90A 3ku1H-2p1rA:
2.3		 3ku1H-2p1rA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 10 ALA A  16
LEU A  93
ASN A  12
LEU A  11
VAL A  39
 None
 1.14A 3o02A-2p1rA:
undetectable
3o02B-2p1rA:
undetectable		 3o02A-2p1rA:
22.22
3o02B-2p1rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		4 / 6 ALA A  63
ILE A  70
LEU A  88
ALA A 116
 None
NA  A 300 (-4.9A)
None
None
 0.86A 3r9sC-2p1rA:
undetectable		 3r9sC-2p1rA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_2
(NEURAMINIDASE)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		4 / 5 ASP A  51
ARG A  54
ARG A  55
ILE A  80
 None
 1.48A 3sanA-2p1rA:
undetectable		 3sanA-2p1rA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_2
(NEURAMINIDASE)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		4 / 5 ASP A  51
ARG A  54
ARG A  55
ILE A  80
 None
 1.48A 3sanB-2p1rA:
undetectable		 3sanB-2p1rA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		4 / 8 LEU A   8
VAL A  73
TYR A  49
LEU A  56
 None
 0.95A 3v81A-2p1rA:
undetectable		 3v81A-2p1rA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 12 ILE A 264
LEU A 268
PHE A 266
ILE A 280
ILE A 258
 None
 1.00A 4fhbA-2p1rA:
undetectable		 4fhbA-2p1rA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 12 GLY A  65
GLY A  64
ASN A 137
GLY A 201
LEU A 297
 None
 0.89A 4fp9A-2p1rA:
undetectable		 4fp9A-2p1rA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 12 GLY A  65
GLY A  64
ASN A 137
GLY A 201
LEU A 297
 None
 0.88A 4fp9C-2p1rA:
undetectable		 4fp9C-2p1rA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 12 GLY A  65
GLY A  64
ASN A 137
GLY A 201
LEU A 297
 None
 0.90A 4fp9D-2p1rA:
undetectable		 4fp9D-2p1rA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 12 GLY A  65
GLY A  64
ASN A 137
GLY A 201
LEU A 297
 None
 0.93A 4fp9F-2p1rA:
undetectable		 4fp9F-2p1rA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		4 / 8 GLY A 219
ILE A 124
LEU A 298
LEU A 297
 CA  A 301 ( 4.8A)
None
None
None
 0.72A 4mwzB-2p1rA:
undetectable		 4mwzB-2p1rA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 12 ILE A 264
LEU A 268
PHE A 266
ILE A 280
ILE A 258
 None
 1.02A 4p3rA-2p1rA:
undetectable		 4p3rA-2p1rA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		4 / 8 LEU A   8
VAL A  73
TYR A  49
LEU A  56
 None
 0.94A 4puoC-2p1rA:
undetectable		 4puoC-2p1rA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		4 / 8 LEU A   8
VAL A  73
TYR A  49
LEU A  56
 None
 0.99A 4pwdA-2p1rA:
1.6		 4pwdA-2p1rA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		4 / 8 LEU A   8
VAL A  73
TYR A  49
LEU A  56
 None
 0.89A 4q0bA-2p1rA:
1.4		 4q0bA-2p1rA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 12 ILE A 264
LEU A 268
PHE A 266
ILE A 280
ILE A 258
 None
 1.00A 5e8qA-2p1rA:
undetectable		 5e8qA-2p1rA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 12 ILE A 264
LEU A 273
PHE A 266
ILE A 280
ILE A 258
 None
 1.12A 5e8qA-2p1rA:
undetectable		 5e8qA-2p1rA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 12 ILE A 248
GLY A 197
THR A 140
LEU A 165
HIS A 167
 CA  A 302 (-4.5A)
None
None
None
None
 1.35A 5esgA-2p1rA:
undetectable		 5esgA-2p1rA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		3 / 3 CYH A 211
MET A 138
ASN A 200
 None
None
CA  A 301 (-3.8A)
 1.10A 5qh8A-2p1rA:
undetectable		 5qh8A-2p1rA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		3 / 3 THR A 174
MET A 172
HIS A 167
 None
 0.98A 5uunA-2p1rA:
undetectable		 5uunA-2p1rA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 12 ILE A 264
LEU A 268
PHE A 266
ILE A 280
ILE A 258
 None
 0.98A 5z6jA-2p1rA:
undetectable		 5z6jA-2p1rA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2p1r LIPID KINASE YEGS
(Salmonella
enterica) 		5 / 12 ILE A 264
LEU A 268
PHE A 266
ILE A 280
ILE A 258
 None
 0.95A 5z6kA-2p1rA:
undetectable		 5z6kA-2p1rA:
19.42