SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p1z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2p1z PHOSPHORIBOSYLTRANSF
ERASE
(Corynebacterium
diphtheriae) 		5 / 10 VAL A 148
TYR A 165
GLY A 153
THR A 123
ALA A 154
 None
 1.34A 2coiA-2p1zA:
undetectable
2coiB-2p1zA:
undetectable		 2coiA-2p1zA:
21.19
2coiB-2p1zA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2p1z PHOSPHORIBOSYLTRANSF
ERASE
(Corynebacterium
diphtheriae) 		3 / 3 ASP A 119
ASP A  34
ASP A  72
 None
 0.78A 3douA-2p1zA:
3.2		 3douA-2p1zA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 2p1z PHOSPHORIBOSYLTRANSF
ERASE
(Corynebacterium
diphtheriae) 		4 / 8 GLY A  49
LEU A  51
LEU A  52
ILE A 168
 None
 0.82A 3nbqC-2p1zA:
undetectable		 3nbqC-2p1zA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 2p1z PHOSPHORIBOSYLTRANSF
ERASE
(Corynebacterium
diphtheriae) 		4 / 8 ALA A  44
ILE A  48
LEU A   7
ALA A  15
 None
 0.72A 3r9tA-2p1zA:
undetectable		 3r9tA-2p1zA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 2p1z PHOSPHORIBOSYLTRANSF
ERASE
(Corynebacterium
diphtheriae) 		5 / 12 LEU A 174
GLU A   9
ALA A  15
GLU A  13
ARG A  43
 None
 1.49A 4cpzD-2p1zA:
undetectable		 4cpzD-2p1zA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 2p1z PHOSPHORIBOSYLTRANSF
ERASE
(Corynebacterium
diphtheriae) 		5 / 12 LEU A  10
ILE A 168
ASP A 149
LEU A  14
ALA A  38
 None
 0.95A 5h5fA-2p1zA:
undetectable		 5h5fA-2p1zA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2p1z PHOSPHORIBOSYLTRANSF
ERASE
(Corynebacterium
diphtheriae) 		5 / 12 LEU A  47
THR A  76
SER A  77
LEU A  10
LEU A  14
 None
 0.83A 5nfjB-2p1zA:
undetectable		 5nfjB-2p1zA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 2p1z PHOSPHORIBOSYLTRANSF
ERASE
(Corynebacterium
diphtheriae) 		5 / 12 GLY A  70
GLY A  65
ASP A 119
ASP A  34
ASP A  72
 None
 1.35A 5yniA-2p1zA:
undetectable		 5yniA-2p1zA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 2p1z PHOSPHORIBOSYLTRANSF
ERASE
(Corynebacterium
diphtheriae) 		5 / 12 LYS A   1
THR A  56
ALA A   8
LEU A  52
LEU A 169
 None
 1.22A 6ie8A-2p1zA:
undetectable		 6ie8A-2p1zA:
24.88