SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p22'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
PROTEIN SRN2
HYPOTHETICAL 12.0
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 PHE D  71
TYR D  75
LEU C  58
VAL A 232
 None
 1.24A 1dz6A-2p22D:
undetectable		 1dz6A-2p22D:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
PROTEIN SRN2
HYPOTHETICAL 12.0
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 PHE D  71
TYR D  75
LEU C  58
VAL A 232
 None
 1.20A 1t88B-2p22D:
undetectable		 1t88B-2p22D:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2p22 PROTEIN SRN2
SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 326
ARG C 198
ASN C 157
GLN C 194
 None
 1.44A 1t9uA-2p22A:
3.4		 1t9uA-2p22A:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
PROTEIN SRN2
HYPOTHETICAL 12.0
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 PHE D  71
TYR D  75
LEU C  58
VAL A 232
 None
 1.18A 1uyuA-2p22D:
undetectable		 1uyuA-2p22D:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
PROTEIN SRN2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 GLN A 289
ILE A 290
TYR C 130
 None
 0.75A 1vifA-2p22A:
undetectable		 1vifA-2p22A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 28
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 372
PHE A 371
ARG B 114
 None
 0.86A 1xdkB-2p22A:
undetectable		 1xdkB-2p22A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
PROTEIN SRN2
HYPOTHETICAL 12.0
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 PHE D  71
TYR D  75
LEU C  58
VAL A 232
 None
 1.20A 2m56A-2p22D:
undetectable		 2m56A-2p22D:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
HYPOTHETICAL 12.0
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 VAL A 332
ASP A 335
GLU D   6
 None
None
SO4  C 215 (-4.2A)
 0.75A 2qeuA-2p22A:
2.4		 2qeuA-2p22A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
HYPOTHETICAL 12.0
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 VAL A 332
ASP A 335
GLU D   6
 None
None
SO4  C 215 (-4.2A)
 0.73A 2qeuC-2p22A:
undetectable		 2qeuC-2p22A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 28
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 375
ASP B  26
SER B  28
ILE B  29
 None
 1.04A 2xadA-2p22A:
undetectable		 2xadA-2p22A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 28
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 375
ASP B  26
SER B  28
ILE B  29
 None
 1.09A 2xadB-2p22A:
undetectable		 2xadB-2p22A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 28
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 375
ASP B  26
SER B  28
ILE B  29
 None
 1.04A 2xadC-2p22A:
undetectable		 2xadC-2p22A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 2p22 PROTEIN SRN2
(Saccharomyces
cerevisiae) 		3 / 3 LEU C 189
ARG C 192
ILE C 185
 None
 0.66A 2xn5B-2p22C:
undetectable		 2xn5B-2p22C:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PY4_A_TYLA598_1
(LACTOPEROXIDASE)		 2p22 PROTEIN SRN2
SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 301
ARG A 297
GLU C 140
PHE C 141
 None
 1.48A 3py4A-2p22A:
1.9		 3py4A-2p22A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
PROTEIN SRN2
HYPOTHETICAL 12.0
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 PHE D  71
TYR D  75
LEU C  58
VAL A 232
 None
 1.13A 3wrhE-2p22D:
undetectable		 3wrhE-2p22D:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
(Saccharomyces
cerevisiae) 		4 / 5 SER A 307
GLN A 302
SER A 304
VAL A 309
 None
 1.05A 4a99D-2p22A:
undetectable		 4a99D-2p22A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
PROTEIN SRN2
HYPOTHETICAL 12.0
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 PHE D  71
TYR D  75
LEU C  58
VAL A 232
 None
 1.19A 4l49A-2p22D:
undetectable		 4l49A-2p22D:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGD_A_AKNA600_1
(BIFUNCTIONAL AAC/APH)		 2p22 HYPOTHETICAL 12.0
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION
PROTEIN SRN2
(Saccharomyces
cerevisiae) 		5 / 10 GLY C  90
ASP D  55
TYR D  51
GLU C 103
GLU C 104
 None
 1.50A 6cgdA-2p22C:
2.9		 6cgdA-2p22C:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
PROTEIN SRN2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 TYR C 213
ALA A 318
LEU C 150
 None
 0.71A 6d9kF-2p22C:
undetectable		 6d9kF-2p22C:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_H_ZOLH401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
PROTEIN SRN2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 ASP C 182
GLN A 362
GLN A 369
LYS C 186
 None
 1.34A 6g31H-2p22C:
5.8		 6g31H-2p22C:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
PROTEIN SRN2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 ASP C 182
GLN A 362
GLN A 369
LYS C 186
 None
 1.37A 6g31L-2p22C:
4.6		 6g31L-2p22C:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 2p22 HYPOTHETICAL 12.0
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION
PROTEIN SRN2
SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP C 190
ASP A 313
ASN D  16
 None
 0.70A 6gngB-2p22C:
undetectable		 6gngB-2p22C:
15.74