SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 2p25 GLYOXALASE FAMILY
PROTEIN
(Enterococcus
faecalis) 		5 / 10 ASP A 118
ASP A 116
ILE A  11
ILE A  43
VAL A  24
 None
 1.13A 1d4yA-2p25A:
undetectable		 1d4yA-2p25A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2p25 GLYOXALASE FAMILY
PROTEIN
(Enterococcus
faecalis) 		4 / 7 LEU A  77
PHE A  79
LEU A  54
PHE A 114
 None
 0.98A 1wrlE-2p25A:
undetectable
1wrlF-2p25A:
undetectable		 1wrlE-2p25A:
25.60
1wrlF-2p25A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2p25 GLYOXALASE FAMILY
PROTEIN
(Enterococcus
faecalis) 		4 / 8 LEU A 124
PHE A 114
LEU A  91
PHE A  90
 None
 0.90A 2eilP-2p25A:
undetectable
2eilW-2p25A:
undetectable		 2eilP-2p25A:
17.87
2eilW-2p25A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 2p25 GLYOXALASE FAMILY
PROTEIN
(Enterococcus
faecalis) 		5 / 12 TYR A  23
LEU A  54
LEU A  74
PHE A  79
LEU A 122
 None
 1.17A 3vw7A-2p25A:
undetectable		 3vw7A-2p25A:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2p25 GLYOXALASE FAMILY
PROTEIN
(Enterococcus
faecalis) 		4 / 6 LEU A 124
PHE A 114
LEU A  91
PHE A  90
 None
 1.01A 3wg7P-2p25A:
undetectable
3wg7W-2p25A:
undetectable		 3wg7P-2p25A:
17.87
3wg7W-2p25A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 2p25 GLYOXALASE FAMILY
PROTEIN
(Enterococcus
faecalis) 		4 / 8 ILE A  11
GLU A  70
ALA A  13
PRO A 121
 None
 0.82A 4jltA-2p25A:
undetectable		 4jltA-2p25A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2p25 GLYOXALASE FAMILY
PROTEIN
(Enterococcus
faecalis) 		4 / 8 ILE A  11
ALA A  18
THR A  19
TYR A  23
 None
 0.62A 5ecnD-2p25A:
undetectable		 5ecnD-2p25A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2p25 GLYOXALASE FAMILY
PROTEIN
(Enterococcus
faecalis) 		4 / 7 LEU A 124
PHE A 114
LEU A  91
PHE A  90
 None
 0.84A 5z84C-2p25A:
undetectable
5z84J-2p25A:
undetectable		 5z84C-2p25A:
17.87
5z84J-2p25A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2p25 GLYOXALASE FAMILY
PROTEIN
(Enterococcus
faecalis) 		4 / 7 LEU A 124
PHE A 114
LEU A  91
PHE A  90
 None
 0.81A 5z85C-2p25A:
undetectable
5z85J-2p25A:
undetectable		 5z85C-2p25A:
17.87
5z85J-2p25A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2p25 GLYOXALASE FAMILY
PROTEIN
(Enterococcus
faecalis) 		4 / 7 LEU A 124
PHE A 114
LEU A  91
PHE A  90
 None
 0.80A 5zcqP-2p25A:
undetectable
5zcqW-2p25A:
undetectable		 5zcqP-2p25A:
17.87
5zcqW-2p25A:
20.72