SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p28'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 2p28 INTEGRIN BETA-2
(Homo
sapiens) 		4 / 6 PHE B 411
LEU B 347
VAL A  95
GLN A  75
 None
 1.12A 1e7aB-2p28B:
undetectable		 1e7aB-2p28B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2p28 INTEGRIN BETA-2
(Homo
sapiens) 		5 / 10 PHE A  93
VAL B 391
VAL B 417
VAL B 419
LEU B 356
 None
 1.21A 1fe2A-2p28A:
undetectable		 1fe2A-2p28A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 2p28 INTEGRIN BETA-2
(Homo
sapiens) 		4 / 6 ARG B 426
GLU B 424
GLN B 422
PRO A  59
 None
 1.27A 2qqtA-2p28B:
undetectable		 2qqtA-2p28B:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 2p28 INTEGRIN BETA-2
(Homo
sapiens) 		4 / 6 ARG B 426
GLU B 424
GLN B 422
PRO A  59
 None
 1.26A 3gclA-2p28B:
undetectable		 3gclA-2p28B:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 2p28 INTEGRIN BETA-2
INTEGRIN BETA-2
(Homo
sapiens;
Homo
sapiens) 		4 / 6 LEU A  62
GLN B 418
LEU A  83
GLU A  64
 None
 1.07A 3h5gB-2p28A:
undetectable
3h5gC-2p28A:
undetectable		 3h5gB-2p28A:
14.61
3h5gC-2p28A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2p28 INTEGRIN BETA-2
INTEGRIN BETA-2
(Homo
sapiens;
Homo
sapiens) 		4 / 8 GLN B 418
GLN A  66
GLU A  64
THR A  82
 None
 0.82A 3rglA-2p28B:
undetectable		 3rglA-2p28B:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2p28 INTEGRIN BETA-2
(Homo
sapiens) 		6 / 9 ALA A  91
VAL B 393
ILE B 406
ASN A  94
PHE A  93
ALA A  63
 None
None
None
NAG  A 401 (-2.7A)
None
None
 1.24A 5nunA-2p28A:
undetectable		 5nunA-2p28A:
19.82