SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p2c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 2p2c CASPASE-2
CASPASE-2
(Homo
sapiens;
Homo
sapiens) 		3 / 3 TRP P  45
ALA B 244
VAL B 246
 None
 0.99A 1bdwA-2p2cP:
undetectable
1bdwB-2p2cP:
undetectable		 1bdwA-2p2cP:
18.64
1bdwB-2p2cP:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 2p2c CASPASE-2
(Homo
sapiens) 		4 / 8 ASN P 156
ILE P 152
PHE P 145
TYR P 122
 None
 1.21A 3ccfB-2p2cP:
undetectable		 3ccfB-2p2cP:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2p2c CASPASE-2
(Homo
sapiens) 		4 / 6 TYR P  79
TYR B 273
HIS B 280
TRP B 238
 None
 1.30A 4jtrB-2p2cP:
undetectable		 4jtrB-2p2cP:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2p2c CASPASE-2
(Homo
sapiens) 		3 / 3 ASP P  44
VAL B 246
ASN P  78
 None
 0.64A 4lmnA-2p2cP:
undetectable		 4lmnA-2p2cP:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 2p2c CASPASE-2
(Homo
sapiens) 		5 / 10 GLY P 124
LEU P 117
ALA P 149
SER P 153
ALA P 162
 None
 1.29A 4wnuD-2p2cP:
undetectable		 4wnuD-2p2cP:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2p2c CASPASE-2
(Homo
sapiens) 		4 / 4 ALA P 141
PRO B 275
LEU P  86
HIS P  85
 None
 1.33A 5eskA-2p2cP:
undetectable		 5eskA-2p2cP:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2p2c CASPASE-2
(Homo
sapiens) 		6 / 11 ASP P  89
ILE P 128
GLY P  91
LEU P  84
LEU P  99
VAL P  96
 None
 1.35A 5twjD-2p2cP:
undetectable		 5twjD-2p2cP:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2p2c CASPASE-2
(Homo
sapiens) 		3 / 3 PHE P 150
ASP P 155
LEU P 119
 None
 0.77A 5uhbC-2p2cP:
undetectable		 5uhbC-2p2cP:
9.59