SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p2v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		3 / 3 ILE A 258
ILE A 186
THR A 261
 None
None
CL  A 800 ( 3.7A)
 0.64A 1rg7A-2p2vA:
undetectable		 1rg7A-2p2vA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		4 / 5 ALA A 181
PHE A 196
ILE A 258
ASP A 257
 None
CSF  A1001 (-3.5A)
None
None
 1.14A 1yc2D-2p2vA:
undetectable		 1yc2D-2p2vA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		4 / 5 PHE A  65
PHE A  70
PHE A 110
VAL A  63
 None
 1.08A 2lh6A-2p2vA:
undetectable		 2lh6A-2p2vA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		4 / 5 ILE A 101
PRO A  67
VAL A 220
PHE A  64
 None
EDO  A 705 ( 4.8A)
None
None
 1.28A 2ygnA-2p2vA:
undetectable		 2ygnA-2p2vA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		4 / 8 GLY A  25
ASN A  24
ILE A  60
TYR A  86
 CSF  A1001 (-3.4A)
CSF  A1001 (-4.5A)
None
None
 0.96A 2yoeB-2p2vA:
undetectable
2yoeC-2p2vA:
undetectable		 2yoeB-2p2vA:
22.38
2yoeC-2p2vA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		4 / 8 GLU A   7
LYS A   5
ASN A  90
ILE A  88
 None
 1.18A 3kp6A-2p2vA:
undetectable
3kp6B-2p2vA:
undetectable		 3kp6A-2p2vA:
20.21
3kp6B-2p2vA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		5 / 8 ILE A  19
ILE A 154
PHE A  43
LEU A 214
VAL A 220
 None
 1.49A 3ua5A-2p2vA:
undetectable		 3ua5A-2p2vA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		4 / 8 ILE A 168
ILE A 222
SER A 203
GLU A 209
 CSF  A1001 (-4.3A)
None
None
None
 0.83A 3ua5A-2p2vA:
undetectable		 3ua5A-2p2vA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		5 / 11 LEU A 211
GLY A 148
ILE A 156
PHE A  92
LEU A 231
 None
CSF  A1001 (-3.8A)
None
None
None
 1.14A 3zosA-2p2vA:
undetectable
3zosB-2p2vA:
undetectable		 3zosA-2p2vA:
18.73
3zosB-2p2vA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		5 / 12 LEU A 225
GLU A 172
GLY A 167
ALA A  22
LEU A 211
 None
 1.17A 4hytA-2p2vA:
undetectable		 4hytA-2p2vA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		5 / 12 LEU A 225
GLU A 172
GLY A 167
ALA A  22
LEU A 211
 None
 1.16A 4hytC-2p2vA:
undetectable		 4hytC-2p2vA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		3 / 3 PHE A 190
THR A  95
LEU A 274
 None
None
EDO  A 704 (-3.4A)
 0.73A 4qztA-2p2vA:
undetectable		 4qztA-2p2vA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		5 / 12 LEU A 225
GLU A 172
GLY A 167
ALA A  22
LEU A 211
 None
 1.17A 4retA-2p2vA:
undetectable		 4retA-2p2vA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		5 / 12 LEU A 225
GLU A 172
GLY A 167
ALA A  22
LEU A 211
 None
 1.17A 4retC-2p2vA:
undetectable		 4retC-2p2vA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		3 / 3 ASN A  32
PHE A 245
TYR A  55
 None
 0.83A 4u15A-2p2vA:
0.2		 4u15A-2p2vA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		5 / 12 TYR A 121
ALA A 210
GLU A 209
ASN A 137
TYR A 206
 None
 1.27A 4ymgA-2p2vA:
undetectable		 4ymgA-2p2vA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		5 / 12 ILE A  19
LEU A 214
LEU A 158
GLY A 159
ILE A 154
 None
 1.08A 5j7wD-2p2vA:
undetectable		 5j7wD-2p2vA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		5 / 10 PHE A 170
ALA A 232
LEU A 231
ILE A 156
LEU A 127
 None
 1.19A 5oy01-2p2vA:
undetectable
5oy07-2p2vA:
undetectable		 5oy01-2p2vA:
13.87
5oy07-2p2vA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		5 / 12 PHE A 170
SER A 229
ILE A 230
ALA A 224
ALA A  22
 None
 0.95A 5vcgA-2p2vA:
undetectable		 5vcgA-2p2vA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		5 / 10 LEU A 211
ILE A 134
PHE A 130
LEU A 158
ALA A 155
 None
 1.27A 5y7pD-2p2vA:
undetectable		 5y7pD-2p2vA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		5 / 10 LEU A 211
ILE A 134
PHE A 130
LEU A 158
ALA A 155
 None
 1.24A 5y7pH-2p2vA:
undetectable		 5y7pH-2p2vA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		5 / 12 ILE A  19
LEU A 214
LEU A 158
GLY A 159
ILE A 154
 None
 1.09A 6qxsB-2p2vA:
undetectable		 6qxsB-2p2vA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		5 / 12 ILE A  19
LEU A 214
LEU A 158
GLY A 159
ILE A 154
 None
 1.05A 6qxsD-2p2vA:
undetectable		 6qxsD-2p2vA:
21.09