SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p2w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		5 / 11 ALA A  75
ALA A  77
VAL A  93
TYR A  82
LEU A  84
 None
 1.29A 1hbpA-2p2wA:
undetectable		 1hbpA-2p2wA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		3 / 3 ARG A 325
SER A  99
TYR A 196
 FLC  A 401 ( 3.1A)
None
None
 0.67A 1x70A-2p2wA:
undetectable		 1x70A-2p2wA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		4 / 4 LEU A 306
SER A 303
TYR A 302
LEU A 267
 None
 1.14A 1xz1A-2p2wA:
undetectable		 1xz1A-2p2wA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		4 / 4 LEU A 306
SER A 303
TYR A 302
LEU A 267
 None
 1.14A 1xz3A-2p2wA:
undetectable		 1xz3A-2p2wA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		5 / 7 HIS A 211
ASN A 298
ASP A 257
THR A 318
GLY A 212
 FLC  A 401 ( 4.5A)
FLC  A 401 ( 4.0A)
None
None
FLC  A 401 ( 4.0A)
 1.35A 2f6dA-2p2wA:
undetectable		 2f6dA-2p2wA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		5 / 9 LEU A  98
ALA A 202
LEU A 203
ALA A 322
PHE A 122
 None
 1.02A 2vcvD-2p2wA:
undetectable		 2vcvD-2p2wA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		5 / 9 LEU A 195
LEU A  98
ALA A 202
LEU A 203
PHE A 122
 None
 1.05A 2vcvD-2p2wA:
undetectable		 2vcvD-2p2wA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		5 / 9 LEU A  98
ALA A 202
LEU A 203
ALA A 322
PHE A 122
 None
 1.04A 2vcvH-2p2wA:
undetectable		 2vcvH-2p2wA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		5 / 9 LEU A 195
LEU A  98
ALA A 202
LEU A 203
PHE A 122
 None
 1.15A 2vcvH-2p2wA:
undetectable		 2vcvH-2p2wA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		5 / 9 LEU A  98
ALA A 202
LEU A 203
ALA A 322
PHE A 122
 None
 1.02A 2vcvI-2p2wA:
undetectable		 2vcvI-2p2wA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		5 / 9 LEU A 195
LEU A  98
ALA A 202
LEU A 203
PHE A 122
 None
 1.06A 2vcvI-2p2wA:
undetectable		 2vcvI-2p2wA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		5 / 9 PHE A  42
GLU A  44
MET A  67
PHE A  63
GLU A  59
 None
 1.34A 2w98A-2p2wA:
undetectable		 2w98A-2p2wA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		5 / 7 VAL A 326
ILE A 199
ALA A 202
GLY A 328
THR A 330
 None
 1.22A 2xrzB-2p2wA:
undetectable		 2xrzB-2p2wA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		4 / 8 ALA A 319
LEU A 320
MET A 316
ILE A 139
 None
 0.74A 3cldB-2p2wA:
undetectable		 3cldB-2p2wA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		5 / 12 GLY A 328
THR A 323
LEU A  49
HIS A 147
ALA A  46
 None
 1.03A 3d91A-2p2wA:
undetectable		 3d91A-2p2wA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		4 / 6 LEU A 165
SER A 168
LEU A 172
LEU A 306
 None
 0.92A 3f33A-2p2wA:
undetectable		 3f33A-2p2wA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		4 / 7 LEU A 111
LYS A 109
ARG A 112
ALA A 115
 None
 1.17A 3mbgA-2p2wA:
1.4
3mbgB-2p2wA:
1.2		 3mbgA-2p2wA:
17.31
3mbgB-2p2wA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		3 / 4 SER A  99
GLY A 204
GLU A 216
 None
 0.69A 3raeA-2p2wA:
undetectable
3raeC-2p2wA:
undetectable		 3raeA-2p2wA:
20.86
3raeC-2p2wA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		4 / 6 LEU A 165
SER A 168
ALA A  37
LEU A 306
 None
 0.76A 3ravA-2p2wA:
undetectable		 3ravA-2p2wA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		4 / 6 LEU A 165
SER A 168
ALA A  37
LEU A 306
 None
 0.78A 3rd0A-2p2wA:
undetectable		 3rd0A-2p2wA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		4 / 7 LEU A  54
GLU A  44
PRO A  32
ILE A  31
 None
 0.86A 3s56B-2p2wA:
undetectable		 3s56B-2p2wA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		5 / 12 GLY A 201
ALA A 184
ALA A 189
ASP A 194
VAL A 200
 None
 1.32A 4df3A-2p2wA:
undetectable		 4df3A-2p2wA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		3 / 3 ARG A 131
LYS A 134
LYS A 136
 None
 1.47A 4k50A-2p2wA:
undetectable		 4k50A-2p2wA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUF_A_ACTA605_0
(SERUM ALBUMIN)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		4 / 4 ALA A 324
HIS A 147
PHE A  42
LEU A 166
 None
 1.42A 4lufA-2p2wA:
0.0		 4lufA-2p2wA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA609_0
(SERUM ALBUMIN)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		4 / 4 ALA A 324
HIS A 147
PHE A  42
LEU A 166
 None
 1.45A 4luhA-2p2wA:
0.5		 4luhA-2p2wA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2p2w CITRATE SYNTHASE
(Thermotoga
maritima) 		5 / 7 ILE A 295
GLY A 249
LEU A 267
PHE A 277
ASP A 300
 None
FLC  A 402 ( 3.9A)
None
None
FLC  A 401 ( 3.0A)
 1.41A 5hieB-2p2wA:
undetectable		 5hieB-2p2wA:
20.76