SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p2y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2p2y ALPHA-RIBAZOLE-5'-PH
OSPHATE PHOSPHATASE
(Thermus
thermophilus) 		4 / 7 VAL A 150
VAL A 158
LEU A   3
LEU A 141
 None
 0.75A 1pthA-2p2yA:
undetectable		 1pthA-2p2yA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2p2y ALPHA-RIBAZOLE-5'-PH
OSPHATE PHOSPHATASE
(Thermus
thermophilus) 		4 / 7 VAL A 150
VAL A 158
LEU A   3
LEU A 141
 None
 0.74A 1pthB-2p2yA:
undetectable		 1pthB-2p2yA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 2p2y ALPHA-RIBAZOLE-5'-PH
OSPHATE PHOSPHATASE
(Thermus
thermophilus) 		4 / 6 MET A   1
MET A   5
LEU A 130
PHE A  48
 None
 0.93A 1x8vA-2p2yA:
undetectable		 1x8vA-2p2yA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2p2y ALPHA-RIBAZOLE-5'-PH
OSPHATE PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 GLY A 134
GLY A 135
ARG A  54
PRO A  66
LEU A  68
 CL  A1001 (-3.6A)
None
None
None
None
 1.11A 3m6vA-2p2yA:
undetectable		 3m6vA-2p2yA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2p2y ALPHA-RIBAZOLE-5'-PH
OSPHATE PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 GLY A 134
GLY A 135
ARG A  54
PRO A  66
LEU A  68
 CL  A1001 (-3.6A)
None
None
None
None
 1.03A 3m6vB-2p2yA:
undetectable		 3m6vB-2p2yA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 2p2y ALPHA-RIBAZOLE-5'-PH
OSPHATE PHOSPHATASE
(Thermus
thermophilus) 		4 / 8 ARG A  54
HIS A 133
VAL A 117
ASP A  51
 None
 1.17A 3uy4A-2p2yA:
undetectable		 3uy4A-2p2yA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2p2y ALPHA-RIBAZOLE-5'-PH
OSPHATE PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 ILE A  75
LEU A  96
PHE A  77
GLY A  78
GLY A 107
 None
 1.17A 5l6eA-2p2yA:
undetectable		 5l6eA-2p2yA:
20.26