SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p31'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 2p31 GLUTATHIONE
PEROXIDASE 7
(Homo
sapiens) 		4 / 7 THR A  60
TYR A  64
ASN A  52
LEU A  67
 None
 1.05A 1qzrA-2p31A:
undetectable		 1qzrA-2p31A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 2p31 GLUTATHIONE
PEROXIDASE 7
(Homo
sapiens) 		4 / 7 THR A  60
TYR A  64
ASN A  52
LEU A  67
 None
 1.06A 1qzrB-2p31A:
undetectable		 1qzrB-2p31A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2p31 GLUTATHIONE
PEROXIDASE 7
(Homo
sapiens) 		4 / 8 ASN A  97
GLU A  99
ILE A 100
ASN A  87
 None
 1.08A 4d33A-2p31A:
undetectable		 4d33A-2p31A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2p31 GLUTATHIONE
PEROXIDASE 7
(Homo
sapiens) 		4 / 7 ASN A  97
GLU A  99
ILE A 100
ASN A  87
 None
 1.04A 4d33B-2p31A:
undetectable		 4d33B-2p31A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2p31 GLUTATHIONE
PEROXIDASE 7
(Homo
sapiens) 		4 / 8 ASN A  97
GLU A  99
ILE A 100
ASN A  87
 None
 1.10A 4d39A-2p31A:
undetectable		 4d39A-2p31A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2p31 GLUTATHIONE
PEROXIDASE 7
(Homo
sapiens) 		4 / 7 ASN A  97
GLU A  99
ILE A 100
ASN A  87
 None
 1.11A 4d39B-2p31A:
undetectable		 4d39B-2p31A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 2p31 GLUTATHIONE
PEROXIDASE 7
(Homo
sapiens) 		4 / 6 PHE A 129
HIS A 126
ILE A 118
PHE A 115
 None
 1.27A 4o7gB-2p31A:
undetectable		 4o7gB-2p31A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2p31 GLUTATHIONE
PEROXIDASE 7
(Homo
sapiens) 		5 / 12 VAL A  50
LEU A  49
SER A  48
GLY A 157
LEU A 132
 None
 0.97A 4rrwD-2p31A:
undetectable		 4rrwD-2p31A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2p31 GLUTATHIONE
PEROXIDASE 7
(Homo
sapiens) 		5 / 12 VAL A  50
LEU A  49
SER A  48
GLY A 157
LEU A 132
 None
 0.97A 4rrzD-2p31A:
undetectable		 4rrzD-2p31A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2p31 GLUTATHIONE
PEROXIDASE 7
(Homo
sapiens) 		5 / 9 VAL A  50
LEU A  49
SER A  48
GLY A 157
LEU A 132
 None
 0.88A 4rs0A-2p31A:
undetectable		 4rs0A-2p31A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_A_NCTA405_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4)		 2p31 GLUTATHIONE
PEROXIDASE 7
(Homo
sapiens) 		4 / 6 TYR A 147
THR A 141
CYH A  86
THR A 121
 None
 1.43A 6cnkA-2p31A:
undetectable
6cnkB-2p31A:
undetectable		 6cnkA-2p31A:
17.24
6cnkB-2p31A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 2p31 GLUTATHIONE
PEROXIDASE 7
(Homo
sapiens) 		4 / 4 LYS A 146
LEU A  49
ALA A 158
LEU A 148
 None
 1.41A 6gnrA-2p31A:
undetectable		 6gnrA-2p31A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 2p31 GLUTATHIONE
PEROXIDASE 7
(Homo
sapiens) 		4 / 4 LYS A 146
LEU A  49
ALA A 158
LEU A 148
 None
 1.39A 6gnrB-2p31A:
undetectable		 6gnrB-2p31A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 2p31 GLUTATHIONE
PEROXIDASE 7
(Homo
sapiens) 		5 / 12 ALA A  66
TYR A  64
TYR A 108
PHE A 144
VAL A 163
 None
 1.28A 6hu9N-2p31A:
undetectable		 6hu9N-2p31A:
17.53