SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p35'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 6 LEU A  37
LEU A 112
LEU A 119
LEU A 249
 None
 0.92A 1errA-2p35A:
undetectable		 1errA-2p35A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 6 ALA A 126
LEU A  28
LEU A 119
ASP A  94
 None
 0.87A 1mt1D-2p35A:
undetectable
1mt1E-2p35A:
undetectable		 1mt1D-2p35A:
16.99
1mt1E-2p35A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 7 LEU A 119
ALA A  93
ILE A  60
PRO A  89
 None
 0.84A 1oniB-2p35A:
undetectable
1oniC-2p35A:
undetectable		 1oniB-2p35A:
23.00
1oniC-2p35A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		3 / 3 PRO A  41
ASP A  61
ASP A  36
 None
SAH  A 301 (-2.7A)
SAH  A 301 ( 4.4A)
 0.81A 1sqfA-2p35A:
13.2		 1sqfA-2p35A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		3 / 3 GLY A  38
ASP A  61
ASN A  99
 SAH  A 301 (-3.6A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.8A)
 0.59A 1vq1A-2p35A:
11.4		 1vq1A-2p35A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 12 PRO A  41
GLY A  42
ASN A  43
ASP A  63
ASP A  83
 None
None
None
None
SAH  A 301 (-3.2A)
 0.76A 2b9eA-2p35A:
13.6		 2b9eA-2p35A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 12 PRO A  41
GLY A  42
ASN A  43
ASP A  63
PHE A 102
 None
 1.22A 2b9eA-2p35A:
13.6		 2b9eA-2p35A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		3 / 3 ARG A 229
GLY A 148
PRO A 149
 None
 0.49A 2hreD-2p35A:
undetectable		 2hreD-2p35A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 4 ASP A  50
ASP A  36
ASP A  13
GLY A  42
 None
SAH  A 301 ( 4.4A)
None
None
 1.34A 2igtC-2p35A:
13.2		 2igtC-2p35A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 12 ASP A  36
LEU A  37
GLY A  38
GLY A  40
ASN A  99
 SAH  A 301 ( 4.4A)
None
SAH  A 301 (-3.6A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.8A)
 0.94A 2nxeB-2p35A:
15.0		 2nxeB-2p35A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 4 PRO A  41
ASP A  61
ASP A  83
ASP A  36
 None
SAH  A 301 (-2.7A)
SAH  A 301 (-3.2A)
SAH  A 301 ( 4.4A)
 0.99A 2nyuA-2p35A:
13.0		 2nyuA-2p35A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 5 PRO A  41
ASP A  61
ASP A  83
ASP A  36
 None
SAH  A 301 (-2.7A)
SAH  A 301 (-3.2A)
SAH  A 301 ( 4.4A)
 1.06A 2nyuB-2p35A:
13.6		 2nyuB-2p35A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 7 GLY A  40
ASP A  61
ASP A  83
LEU A  84
 SAH  A 301 (-3.3A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.8A)
 0.40A 2uyqA-2p35A:
11.3		 2uyqA-2p35A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 12 LEU A  37
GLY A  38
GLY A  40
ASP A  63
ASN A  99
 None
SAH  A 301 (-3.6A)
SAH  A 301 (-3.3A)
None
SAH  A 301 (-3.8A)
 0.99A 3cjtO-2p35A:
14.9		 3cjtO-2p35A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 12 GLY A  38
GLY A  40
ASP A  83
ASN A  99
VAL A 105
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.8A)
SAH  A 301 ( 4.5A)
 0.97A 3dmfA-2p35A:
12.6		 3dmfA-2p35A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 12 GLY A  38
GLY A  40
ASP A  83
LEU A  84
VAL A 101
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.1A)
 0.40A 3o7wA-2p35A:
10.7		 3o7wA-2p35A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 12 LEU A  95
LEU A  22
LEU A  23
ILE A  57
LEU A  37
 None
 1.18A 3olsB-2p35A:
undetectable		 3olsB-2p35A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		3 / 3 GLY A  40
ASP A  61
ASP A  83
 SAH  A 301 (-3.3A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.2A)
 0.30A 3ou7C-2p35A:
14.5		 3ou7C-2p35A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 7 LEU A 244
TYR A 226
THR A 227
ILE A 230
 None
 0.97A 3p50A-2p35A:
undetectable		 3p50A-2p35A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 7 LEU A 244
TYR A 226
THR A 227
ILE A 230
 None
 0.97A 3p50B-2p35A:
undetectable		 3p50B-2p35A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 7 LEU A 244
TYR A 226
THR A 227
ILE A 230
 None
 0.97A 3p50C-2p35A:
undetectable		 3p50C-2p35A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 7 LEU A 244
TYR A 226
THR A 227
ILE A 230
 None
 0.96A 3p50D-2p35A:
undetectable		 3p50D-2p35A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 7 LEU A 244
TYR A 226
THR A 227
ILE A 230
 None
 0.93A 3p50E-2p35A:
undetectable		 3p50E-2p35A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 11 GLY A  40
ASP A  61
SER A  62
ASP A  63
ASP A  83
 SAH  A 301 (-3.3A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.3A)
None
SAH  A 301 (-3.2A)
 0.60A 3v8vB-2p35A:
9.6		 3v8vB-2p35A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 12 GLY A  38
PRO A  41
GLY A  42
ASP A  61
ASP A  83
 SAH  A 301 (-3.6A)
None
None
SAH  A 301 (-2.7A)
SAH  A 301 (-3.2A)
 0.66A 4b17A-2p35A:
13.1		 4b17A-2p35A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 11 ASP A  36
GLY A  38
GLY A  40
ASP A  61
ASN A  99
 SAH  A 301 ( 4.4A)
SAH  A 301 (-3.6A)
SAH  A 301 (-3.3A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.8A)
 0.93A 4dcmA-2p35A:
11.9		 4dcmA-2p35A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		3 / 3 ARG A 229
TRP A 150
GLY A 148
 None
 0.99A 4e7cA-2p35A:
1.7		 4e7cA-2p35A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 12 GLY A  38
GLY A  40
ASP A  61
MET A  66
ASP A  83
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.3A)
SAH  A 301 (-2.7A)
SAH  A 301 (-4.7A)
SAH  A 301 (-3.2A)
 0.70A 4iv8A-2p35A:
15.3		 4iv8A-2p35A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 12 GLY A  38
GLY A  40
MET A  66
LEU A  84
VAL A 101
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.3A)
SAH  A 301 (-4.7A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.1A)
 0.98A 4qdjA-2p35A:
15.7		 4qdjA-2p35A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		3 / 3 ARG A  15
ASN A  43
ASP A  50
 None
 0.89A 5gwxA-2p35A:
17.4		 5gwxA-2p35A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 6 GLY A  38
ASP A  83
GLY A  59
GLY A  80
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.2A)
None
None
 0.65A 6ag0C-2p35A:
undetectable		 6ag0C-2p35A:
15.04