SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p38'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 2p38 PROTEIN INVOLVED IN
RIBOSOMAL BIOGENESIS
(Pyrococcus
abyssi) 		3 / 3 ASP A  42
PHE A  81
VAL A  68
 None
 0.73A 1kijB-2p38A:
undetectable		 1kijB-2p38A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 2p38 PROTEIN INVOLVED IN
RIBOSOMAL BIOGENESIS
(Pyrococcus
abyssi) 		4 / 7 PHE A 108
PHE A  88
ILE A  91
GLY A 143
 None
 0.97A 2v0mB-2p38A:
undetectable		 2v0mB-2p38A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2p38 PROTEIN INVOLVED IN
RIBOSOMAL BIOGENESIS
(Pyrococcus
abyssi) 		5 / 12 PHE A 108
ILE A 140
ILE A  99
GLU A 121
ILE A 122
 None
 1.22A 3fpjB-2p38A:
undetectable		 3fpjB-2p38A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 2p38 PROTEIN INVOLVED IN
RIBOSOMAL BIOGENESIS
(Pyrococcus
abyssi) 		6 / 9 ALA A 114
ILE A 140
GLY A 141
ILE A 142
ILE A 122
VAL A 119
 None
 1.39A 4nptA-2p38A:
undetectable		 4nptA-2p38A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2p38 PROTEIN INVOLVED IN
RIBOSOMAL BIOGENESIS
(Pyrococcus
abyssi) 		4 / 7 ASN A 146
PHE A 153
ILE A 145
GLY A 126
 None
 0.89A 5nzyA-2p38A:
undetectable		 5nzyA-2p38A:
20.60