SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p3e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 7 TYR A  51
ILE A 212
TYR A 215
GLY A 243
 None
 0.85A 11gsA-2p3eA:
undetectable		 11gsA-2p3eA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 7 TYR A  51
ILE A 212
TYR A 215
GLY A 243
 None
 0.86A 11gsB-2p3eA:
undetectable		 11gsB-2p3eA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.79A 1c6yB-2p3eA:
undetectable		 1c6yB-2p3eA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.92A 1c6zA-2p3eA:
undetectable		 1c6zA-2p3eA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.88A 1c6zB-2p3eA:
undetectable		 1c6zB-2p3eA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 9 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.90A 1hpvB-2p3eA:
undetectable		 1hpvB-2p3eA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.85A 1hxbB-2p3eA:
undetectable		 1hxbB-2p3eA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		3 / 3 GLU A 227
LYS A 221
VAL A 223
 None
 0.91A 1l2iA-2p3eA:
undetectable		 1l2iA-2p3eA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 10 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.84A 1muiA-2p3eA:
undetectable		 1muiA-2p3eA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 9 VAL A 105
LEU A 125
VAL A 199
GLY A 200
ALA A 152
 None
 1.24A 1pxxB-2p3eA:
undetectable		 1pxxB-2p3eA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 10 VAL A 105
LEU A 125
VAL A 199
GLY A 200
ALA A 152
 None
 1.23A 1pxxD-2p3eA:
undetectable		 1pxxD-2p3eA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.86A 1rl8A-2p3eA:
undetectable		 1rl8A-2p3eA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 11 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.79A 1t3rB-2p3eA:
undetectable		 1t3rB-2p3eA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 7 ALA A 355
VAL A 371
GLY A 345
ILE A 308
 None
 0.80A 1t7iB-2p3eA:
undetectable		 1t7iB-2p3eA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 7 ALA A 355
VAL A 371
GLY A 345
ILE A 308
 None
 0.80A 1t7jB-2p3eA:
undetectable		 1t7jB-2p3eA:
13.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TUF_A_AZ1A502_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		6 / 9 HIS A 204
GLY A 206
SER A 207
ARG A 282
ARG A 318
TYR A 322
 None
 0.58A 1tufA-2p3eA:
52.9
1tufB-2p3eA:
53.1		 1tufA-2p3eA:
42.99
1tufB-2p3eA:
42.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 6 SER A 207
ARG A 282
ARG A 318
TYR A 322
TYR A 377
 None
 0.66A 1tufA-2p3eA:
52.9
1tufB-2p3eA:
53.1		 1tufA-2p3eA:
42.99
1tufB-2p3eA:
42.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.80A 2f80A-2p3eA:
undetectable		 2f80A-2p3eA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.87A 2f80B-2p3eA:
undetectable		 2f80B-2p3eA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.88A 2f81A-2p3eA:
undetectable		 2f81A-2p3eA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 8 TYR A  51
ILE A 212
TYR A 215
GLY A 243
 None
 0.90A 2gssA-2p3eA:
undetectable		 2gssA-2p3eA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 8 TYR A  51
ILE A 212
TYR A 215
GLY A 243
 None
 0.90A 2gssB-2p3eA:
undetectable		 2gssB-2p3eA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.87A 2ienA-2p3eA:
undetectable		 2ienA-2p3eA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.82A 2o4kB-2p3eA:
undetectable		 2o4kB-2p3eA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.80A 2o4sA-2p3eA:
undetectable		 2o4sA-2p3eA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 9 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.82A 2q5kA-2p3eA:
undetectable		 2q5kA-2p3eA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.86A 2qakA-2p3eA:
undetectable		 2qakA-2p3eA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 11 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.91A 2qhcA-2p3eA:
undetectable		 2qhcA-2p3eA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 GLY A 244
GLY A 206
LEU A 210
GLY A 246
PRO A 256
 None
 1.08A 3axzA-2p3eA:
undetectable		 3axzA-2p3eA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.76A 3bvbA-2p3eA:
undetectable		 3bvbA-2p3eA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.86A 3bvbB-2p3eA:
undetectable		 3bvbB-2p3eA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.84A 3cywA-2p3eA:
undetectable		 3cywA-2p3eA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 4 LEU A 316
ASP A 342
VAL A 309
THR A 293
 None
 1.22A 3cyxB-2p3eA:
undetectable		 3cyxB-2p3eA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 LEU A  25
ALA A 374
ALA A 311
VAL A 309
ILE A  20
 None
 0.89A 3czhB-2p3eA:
undetectable		 3czhB-2p3eA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.73A 3d1zA-2p3eA:
undetectable		 3d1zA-2p3eA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.86A 3d20A-2p3eA:
undetectable		 3d20A-2p3eA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 10 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.87A 3ekpB-2p3eA:
undetectable		 3ekpB-2p3eA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 10 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.98A 3ekpC-2p3eA:
undetectable		 3ekpC-2p3eA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 9 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.90A 3ektB-2p3eA:
undetectable		 3ektB-2p3eA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 9 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.80A 3ekvB-2p3eA:
undetectable		 3ekvB-2p3eA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 11 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.92A 3ekxA-2p3eA:
undetectable		 3ekxA-2p3eA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 11 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.89A 3ekxB-2p3eA:
undetectable		 3ekxB-2p3eA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.84A 3el1B-2p3eA:
undetectable		 3el1B-2p3eA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 7 TYR A  51
ILE A 212
TYR A 215
GLY A 243
 None
 0.90A 3gssA-2p3eA:
undetectable		 3gssA-2p3eA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 7 TYR A  51
ILE A 212
TYR A 215
GLY A 243
 None
 0.92A 3gssB-2p3eA:
undetectable		 3gssB-2p3eA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.78A 3jvyA-2p3eA:
undetectable		 3jvyA-2p3eA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.79A 3jw2A-2p3eA:
undetectable		 3jw2A-2p3eA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		3 / 3 ASN A 314
ASP A 352
ARG A 365
 None
 0.85A 3k13A-2p3eA:
7.6		 3k13A-2p3eA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.80A 3k4vB-2p3eA:
undetectable		 3k4vB-2p3eA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.87A 3lzuB-2p3eA:
undetectable		 3lzuB-2p3eA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 11 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.83A 3lzvB-2p3eA:
undetectable		 3lzvB-2p3eA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_B_AG2B1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 9 LYS A  65
HIS A 204
GLY A 206
SER A 207
TYR A 377
 None
 0.73A 3n2oA-2p3eA:
28.9
3n2oB-2p3eA:
29.0		 3n2oA-2p3eA:
24.02
3n2oB-2p3eA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_D_AG2D1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 10 LYS A  65
HIS A 204
GLY A 206
ARG A 282
TYR A 377
 None
 0.66A 3n2oC-2p3eA:
29.1
3n2oD-2p3eA:
28.9		 3n2oC-2p3eA:
24.02
3n2oD-2p3eA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 8 TYR A  51
ILE A 212
TYR A 215
GLY A 243
 None
 0.88A 3n9jA-2p3eA:
undetectable		 3n9jA-2p3eA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.89A 3ndtD-2p3eA:
undetectable		 3ndtD-2p3eA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 11 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.92A 3nu3B-2p3eA:
undetectable		 3nu3B-2p3eA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 10 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.73A 3nu6A-2p3eA:
undetectable		 3nu6A-2p3eA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 8 ALA A 355
VAL A 371
GLY A 345
ILE A 308
 None
 0.77A 3nu9A-2p3eA:
undetectable		 3nu9A-2p3eA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 10 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.78A 3nujA-2p3eA:
undetectable		 3nujA-2p3eA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 9 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.92A 3nujB-2p3eA:
undetectable		 3nujB-2p3eA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 9 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.91A 3nuoB-2p3eA:
undetectable		 3nuoB-2p3eA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.81A 3oxcA-2p3eA:
undetectable		 3oxcA-2p3eA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 11 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.81A 3oy4A-2p3eA:
undetectable		 3oy4A-2p3eA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.79A 3pwmA-2p3eA:
undetectable		 3pwmA-2p3eA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.92A 3tkgD-2p3eA:
undetectable		 3tkgD-2p3eA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.87A 3tkwB-2p3eA:
undetectable		 3tkwB-2p3eA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.87A 3tl9B-2p3eA:
undetectable		 3tl9B-2p3eA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.76A 4dqbA-2p3eA:
undetectable		 4dqbA-2p3eA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 10 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.79A 4dqcA-2p3eA:
undetectable		 4dqcA-2p3eA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 11 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.76A 4dqeA-2p3eA:
undetectable		 4dqeA-2p3eA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.82A 4dqfA-2p3eA:
undetectable		 4dqfA-2p3eA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 11 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.78A 4dqhA-2p3eA:
undetectable		 4dqhA-2p3eA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		3 / 3 TYR A 412
PHE A  68
ARG A 390
 None
 1.06A 4g19D-2p3eA:
undetectable		 4g19D-2p3eA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.72A 4jecB-2p3eA:
undetectable		 4jecB-2p3eA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 LEU A 369
VAL A 295
ILE A 307
GLU A 361
ILE A 360
 None
 1.09A 4ltwA-2p3eA:
undetectable		 4ltwA-2p3eA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 11 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.80A 4njtA-2p3eA:
undetectable		 4njtA-2p3eA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 11 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.84A 4njtC-2p3eA:
undetectable		 4njtC-2p3eA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.80A 4njvA-2p3eA:
undetectable		 4njvA-2p3eA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 LEU A 135
ILE A 198
VAL A 199
ALA A 149
LEU A 196
 None
 1.08A 4o1zB-2p3eA:
undetectable		 4o1zB-2p3eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 10 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.84A 4q1wB-2p3eA:
undetectable		 4q1wB-2p3eA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 5 TYR A  62
TYR A  39
GLU A 393
LEU A  72
 None
 1.17A 4qztB-2p3eA:
undetectable		 4qztB-2p3eA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 11 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.81A 4rvjA-2p3eA:
undetectable		 4rvjA-2p3eA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 9 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.93A 4rvjB-2p3eA:
undetectable		 4rvjB-2p3eA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 11 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.81A 4rvjC-2p3eA:
undetectable		 4rvjC-2p3eA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 9 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.94A 4rvjD-2p3eA:
undetectable		 4rvjD-2p3eA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 9 LEU A  25
LEU A   4
LYS A   5
ASN A   8
LEU A  18
 None
 1.32A 4x30A-2p3eA:
undetectable		 4x30A-2p3eA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 LEU A  18
GLU A   2
VAL A 396
VAL A 394
LEU A  36
 None
 1.11A 4y0qA-2p3eA:
undetectable		 4y0qA-2p3eA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 GLY A 244
GLY A 206
LEU A 210
GLY A 246
PRO A 256
 None
 1.07A 4yvgA-2p3eA:
undetectable		 4yvgA-2p3eA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 LEU A 278
LEU A  59
ILE A  99
GLY A  77
LEU A  76
 None
 1.06A 5gs4A-2p3eA:
undetectable		 5gs4A-2p3eA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 LEU A  79
ALA A  81
PRO A 280
ILE A 247
ILE A  44
 None
 1.10A 5hbsA-2p3eA:
undetectable		 5hbsA-2p3eA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.76A 5kqyA-2p3eA:
undetectable		 5kqyA-2p3eA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		3 / 3 HIS A 326
SER A 373
ARG A 282
 None
 1.03A 5u63A-2p3eA:
undetectable		 5u63A-2p3eA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.84A 6dgxB-2p3eA:
undetectable		 6dgxB-2p3eA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.83A 6dh3B-2p3eA:
undetectable		 6dh3B-2p3eA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 2p3e DIAMINOPIMELATE
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 10 ALA A 355
VAL A 371
GLY A 345
ILE A 308
ILE A 328
 None
 0.79A 6dj2A-2p3eA:
undetectable		 6dj2A-2p3eA:
13.71