SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p3x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A 243
LEU A 121
LEU A 163
GLY A 270
 C2O  A 340 (-3.3A)
None
None
None
 0.98A 1a4lB-2p3xA:
undetectable		 1a4lB-2p3xA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 ARG A 277
ALA A  50
ASP A 145
GLY A 149
 None
 1.15A 1e7bA-2p3xA:
undetectable		 1e7bA-2p3xA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 6 LEU A 199
ASP A 145
ILE A 333
ARG A 277
 None
 0.94A 1mt1A-2p3xA:
undetectable
1mt1F-2p3xA:
undetectable		 1mt1A-2p3xA:
10.62
1mt1F-2p3xA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 6 ILE A 333
ARG A 277
LEU A 199
ASP A 145
 None
 0.95A 1mt1B-2p3xA:
undetectable
1mt1C-2p3xA:
undetectable		 1mt1B-2p3xA:
14.16
1mt1C-2p3xA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 8 LEU A 199
ASP A 145
ILE A 333
ARG A 277
 None
 0.92A 1n13A-2p3xA:
undetectable
1n13F-2p3xA:
undetectable		 1n13A-2p3xA:
10.62
1n13F-2p3xA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 7 LEU A 199
ASP A 145
ILE A 333
ARG A 277
 None
 0.92A 1n13I-2p3xA:
undetectable
1n13L-2p3xA:
undetectable		 1n13I-2p3xA:
10.62
1n13L-2p3xA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 12 TYR A 151
GLY A 149
TYR A 141
ALA A  51
ASP A 148
 None
 1.20A 1nt2A-2p3xA:
undetectable		 1nt2A-2p3xA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 6 ALA A  51
TYR A  62
ILE A 267
PRO A 153
 None
 1.26A 1oniB-2p3xA:
undetectable
1oniC-2p3xA:
undetectable		 1oniB-2p3xA:
16.96
1oniC-2p3xA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 6 ALA A  51
TYR A  62
ILE A 267
PRO A 153
 None
 1.18A 1oniH-2p3xA:
undetectable
1oniI-2p3xA:
undetectable		 1oniH-2p3xA:
16.96
1oniI-2p3xA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 ALA A 237
VAL A 242
TRP A 245
 None
 0.85A 1tkqA-2p3xA:
undetectable		 1tkqA-2p3xA:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 8 LEU A 128
PHE A 137
TYR A  58
LEU A 163
 None
 0.71A 1v55N-2p3xA:
undetectable
1v55W-2p3xA:
undetectable		 1v55N-2p3xA:
19.17
1v55W-2p3xA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 HIS A 272
HIS A 239
HIS A 117
 C2O  A 340 (-3.1A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.5A)
 0.74A 1w2zA-2p3xA:
undetectable		 1w2zA-2p3xA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 12 TYR A 151
THR A 154
PRO A 153
VAL A  54
LEU A  59
 None
 1.37A 1z9hA-2p3xA:
1.0		 1z9hA-2p3xA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 12 TYR A 151
THR A 154
PRO A 153
VAL A  54
LEU A  59
 None
 1.37A 1z9hB-2p3xA:
1.0		 1z9hB-2p3xA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 12 TYR A 151
THR A 154
PRO A 153
VAL A  54
LEU A  59
 None
 1.37A 1z9hC-2p3xA:
1.0		 1z9hC-2p3xA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 6 HIS A 243
ASP A 181
TYR A 182
HIS A 272
 C2O  A 340 (-3.3A)
None
None
C2O  A 340 (-3.1A)
 1.44A 2dysA-2p3xA:
undetectable
2dysC-2p3xA:
undetectable		 2dysA-2p3xA:
19.17
2dysC-2p3xA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 7 HIS A 243
ASP A 181
TYR A 182
HIS A 272
 C2O  A 340 (-3.3A)
None
None
C2O  A 340 (-3.1A)
 1.45A 2eilA-2p3xA:
undetectable
2eilC-2p3xA:
undetectable		 2eilA-2p3xA:
19.17
2eilC-2p3xA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 6 HIS A 243
ASP A 181
TYR A 182
HIS A 272
 C2O  A 340 (-3.3A)
None
None
C2O  A 340 (-3.1A)
 1.48A 2einA-2p3xA:
0.5
2einC-2p3xA:
undetectable		 2einA-2p3xA:
19.17
2einC-2p3xA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 8 LEU A 128
PHE A 137
TYR A  58
LEU A 163
 None
 0.66A 2einA-2p3xA:
undetectable
2einJ-2p3xA:
undetectable		 2einA-2p3xA:
19.17
2einJ-2p3xA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 7 ILE A 333
ARG A 277
LEU A 199
ASP A 145
 None
 0.98A 2qqcB-2p3xA:
undetectable
2qqcC-2p3xA:
undetectable		 2qqcB-2p3xA:
14.24
2qqcC-2p3xA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 7 LEU A 199
ASP A 145
ILE A 333
ARG A 277
 None
 0.96A 2qqcA-2p3xA:
undetectable
2qqcF-2p3xA:
undetectable		 2qqcA-2p3xA:
9.23
2qqcF-2p3xA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 7 LEU A 199
ASP A 145
ILE A 333
ARG A 277
 None
 0.95A 2qqcG-2p3xA:
undetectable
2qqcJ-2p3xA:
undetectable		 2qqcG-2p3xA:
9.23
2qqcJ-2p3xA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 7 LEU A 199
ASP A 145
ILE A 333
ARG A 277
 None
 0.97A 2qqcI-2p3xA:
undetectable
2qqcL-2p3xA:
undetectable		 2qqcI-2p3xA:
9.23
2qqcL-2p3xA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 7 LEU A 199
ASP A 145
ILE A 333
ARG A 277
 None
 0.92A 2qqdA-2p3xA:
undetectable
2qqdE-2p3xA:
undetectable		 2qqdA-2p3xA:
9.23
2qqdE-2p3xA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A 239
HIS A 243
VAL A 275
HIS A 272
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
C2O  A 340 (-3.1A)
 0.93A 2wkoF-2p3xA:
undetectable		 2wkoF-2p3xA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 VAL A 107
TRP A 111
TRP A 298
 None
 1.47A 2xdcA-2p3xA:
undetectable
2xdcB-2p3xA:
undetectable		 2xdcA-2p3xA:
4.02
2xdcB-2p3xA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 VAL A 107
TRP A 298
TRP A 111
 None
 1.39A 2xdcA-2p3xA:
undetectable
2xdcB-2p3xA:
undetectable		 2xdcA-2p3xA:
4.02
2xdcB-2p3xA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 TRP A 111
VAL A 107
TRP A 298
 None
 1.37A 2xdcA-2p3xA:
undetectable
2xdcB-2p3xA:
undetectable		 2xdcA-2p3xA:
4.02
2xdcB-2p3xA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 TRP A 298
VAL A 107
TRP A 111
 None
 1.47A 2xdcA-2p3xA:
undetectable
2xdcB-2p3xA:
undetectable		 2xdcA-2p3xA:
4.02
2xdcB-2p3xA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 VAL A 107
TRP A 298
TRP A 111
 None
 1.05A 2xdcC-2p3xA:
undetectable
2xdcD-2p3xA:
undetectable		 2xdcC-2p3xA:
4.02
2xdcD-2p3xA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 TRP A 111
VAL A 107
TRP A 298
 None
 1.33A 2xdcE-2p3xA:
undetectable
2xdcF-2p3xA:
undetectable		 2xdcE-2p3xA:
4.02
2xdcF-2p3xA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 VAL A 107
TRP A 298
TRP A 111
 None
 1.38A 2y5mA-2p3xA:
undetectable
2y5mB-2p3xA:
undetectable		 2y5mA-2p3xA:
4.02
2y5mB-2p3xA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 VAL A 107
TRP A 298
TRP A 111
 None
 1.38A 2y6nA-2p3xA:
undetectable
2y6nB-2p3xA:
undetectable		 2y6nA-2p3xA:
4.02
2y6nB-2p3xA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 TRP A 111
VAL A 107
TRP A 298
 None
 1.38A 2y6nA-2p3xA:
undetectable
2y6nB-2p3xA:
undetectable		 2y6nA-2p3xA:
4.02
2y6nB-2p3xA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 TRP A 111
VAL A 107
TRP A 298
 None
 1.33A 2y6nC-2p3xA:
undetectable
2y6nD-2p3xA:
undetectable		 2y6nC-2p3xA:
4.02
2y6nD-2p3xA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 TRP A 111
VAL A 107
TRP A 298
 None
 1.34A 2y6nE-2p3xA:
undetectable
2y6nF-2p3xA:
undetectable		 2y6nE-2p3xA:
4.02
2y6nF-2p3xA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.35A 2zweA-2p3xA:
21.1
2zweB-2p3xA:
undetectable		 2zweA-2p3xA:
24.46
2zweB-2p3xA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 239
HIS A 243
HIS A  87
HIS A 108
PRO A  17
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
 1.15A 2zweA-2p3xA:
21.1
2zweB-2p3xA:
undetectable		 2zweA-2p3xA:
24.46
2zweB-2p3xA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.35A 2zwfA-2p3xA:
21.2
2zwfB-2p3xA:
undetectable		 2zwfA-2p3xA:
24.46
2zwfB-2p3xA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 117
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 1.49A 2zwfA-2p3xA:
21.2
2zwfB-2p3xA:
undetectable		 2zwfA-2p3xA:
24.46
2zwfB-2p3xA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 239
HIS A 243
HIS A  87
HIS A 108
PRO A  17
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
 1.19A 2zwfA-2p3xA:
21.2
2zwfB-2p3xA:
undetectable		 2zwfA-2p3xA:
24.46
2zwfB-2p3xA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.35A 2zwgA-2p3xA:
21.1
2zwgB-2p3xA:
undetectable		 2zwgA-2p3xA:
24.46
2zwgB-2p3xA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 239
HIS A 243
HIS A  87
HIS A 108
PRO A  17
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
 1.18A 2zwgA-2p3xA:
21.1
2zwgB-2p3xA:
undetectable		 2zwgA-2p3xA:
24.46
2zwgB-2p3xA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 6 HIS A 243
ASP A 181
TYR A 182
HIS A 272
 C2O  A 340 (-3.3A)
None
None
C2O  A 340 (-3.1A)
 1.45A 2zxwA-2p3xA:
undetectable
2zxwC-2p3xA:
undetectable		 2zxwA-2p3xA:
19.17
2zxwC-2p3xA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 6 HIS A 243
ASP A 181
TYR A 182
HIS A 272
 C2O  A 340 (-3.3A)
None
None
C2O  A 340 (-3.1A)
 1.47A 2zxwN-2p3xA:
undetectable
2zxwP-2p3xA:
undetectable		 2zxwN-2p3xA:
19.17
2zxwP-2p3xA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 7 HIS A 243
ASP A 181
TYR A 182
HIS A 272
 C2O  A 340 (-3.3A)
None
None
C2O  A 340 (-3.1A)
 1.42A 3abkA-2p3xA:
undetectable
3abkC-2p3xA:
undetectable		 3abkA-2p3xA:
19.17
3abkC-2p3xA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 8 LEU A 128
PHE A 137
TYR A  58
LEU A 163
 None
 0.78A 3abkA-2p3xA:
undetectable
3abkJ-2p3xA:
undetectable		 3abkA-2p3xA:
19.17
3abkJ-2p3xA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 8 LEU A 128
PHE A 137
TYR A  58
LEU A 163
 None
 0.79A 3abmN-2p3xA:
undetectable
3abmW-2p3xA:
undetectable		 3abmN-2p3xA:
19.17
3abmW-2p3xA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 7 HIS A 243
ASP A 181
TYR A 182
HIS A 272
 C2O  A 340 (-3.3A)
None
None
C2O  A 340 (-3.1A)
 1.42A 3ag3N-2p3xA:
undetectable
3ag3P-2p3xA:
undetectable		 3ag3N-2p3xA:
19.17
3ag3P-2p3xA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 8 LEU A 128
PHE A 137
TYR A  58
LEU A 163
 None
 0.77A 3asoN-2p3xA:
undetectable
3asoW-2p3xA:
undetectable		 3asoN-2p3xA:
19.17
3asoW-2p3xA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 HIS A 108
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.21A 3qpkA-2p3xA:
undetectable		 3qpkA-2p3xA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 HIS A 108
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.24A 3qpkB-2p3xA:
undetectable		 3qpkB-2p3xA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 8 TYR A 141
TYR A 330
ARG A 118
LEU A 121
 None
 1.29A 3wipG-2p3xA:
undetectable
3wipH-2p3xA:
undetectable		 3wipG-2p3xA:
22.60
3wipH-2p3xA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 8 ARG A 118
LEU A 121
TYR A 141
TYR A 330
 None
 1.29A 3wipF-2p3xA:
undetectable
3wipJ-2p3xA:
undetectable		 3wipF-2p3xA:
22.60
3wipJ-2p3xA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 VAL A 107
TRP A 298
TRP A 111
 None
 1.03A 3zq8A-2p3xA:
undetectable
3zq8B-2p3xA:
undetectable		 3zq8A-2p3xA:
4.02
3zq8B-2p3xA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 7 LEU A 112
TYR A  90
LEU A 105
TYR A 221
 None
 1.13A 4b3qA-2p3xA:
undetectable		 4b3qA-2p3xA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 8 TYR A  95
VAL A  86
TYR A  90
LEU A 312
 None
 0.94A 4jtrA-2p3xA:
undetectable		 4jtrA-2p3xA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 LEU A 248
ASP A 165
ARG A 168
ILE A 267
 None
 1.43A 4mwrA-2p3xA:
undetectable		 4mwrA-2p3xA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		6 / 7 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
ALA A 262
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
None
 0.48A 4p6sA-2p3xA:
21.1		 4p6sA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A 243
HIS A 239
HIS A 108
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
 1.16A 4p6sA-2p3xA:
21.1		 4p6sA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A 243
HIS A 272
HIS A 108
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
 1.41A 4p6sA-2p3xA:
21.1		 4p6sA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.49A 4p6sB-2p3xA:
21.2		 4p6sB-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 7 HIS A 108
HIS A  87
HIS A 243
HIS A 239
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
 0.98A 4p6sB-2p3xA:
21.2		 4p6sB-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 MET A 152
ASP A 265
PHE A 268
 None
None
C2O  A 340 ( 4.7A)
 0.92A 4xeyA-2p3xA:
undetectable		 4xeyA-2p3xA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 MET A 152
ASP A 265
PHE A 268
 None
None
C2O  A 340 ( 4.7A)
 0.87A 4xeyB-2p3xA:
undetectable		 4xeyB-2p3xA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		6 / 7 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
ALA A 262
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
None
 0.44A 5i3aA-2p3xA:
21.3		 5i3aA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A 243
HIS A 239
HIS A 108
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
 1.14A 5i3aA-2p3xA:
21.3		 5i3aA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A 243
HIS A 239
HIS A 117
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
None
 1.50A 5i3aA-2p3xA:
21.3		 5i3aA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A 243
HIS A 272
HIS A 108
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
 1.46A 5i3aA-2p3xA:
21.3		 5i3aA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		6 / 7 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
ALA A 262
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
None
 0.41A 5i3aB-2p3xA:
21.2		 5i3aB-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A 243
HIS A 239
HIS A 108
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
 1.15A 5i3aB-2p3xA:
21.2		 5i3aB-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A 243
HIS A 272
HIS A 108
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
 1.44A 5i3aB-2p3xA:
21.2		 5i3aB-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		6 / 7 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
ALA A 262
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
None
 0.47A 5i3bA-2p3xA:
21.4		 5i3bA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A 243
HIS A 239
HIS A 108
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
 1.14A 5i3bA-2p3xA:
21.4		 5i3bA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A 243
HIS A 239
HIS A 117
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
None
 1.49A 5i3bA-2p3xA:
21.4		 5i3bA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A 243
HIS A 272
HIS A 108
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
 1.46A 5i3bA-2p3xA:
21.4		 5i3bA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A  87
HIS A 108
HIS A 243
ALA A 262
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.3A)
None
 0.41A 5i3bB-2p3xA:
21.4		 5i3bB-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A  87
HIS A 117
HIS A 243
ALA A 262
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.3A)
None
 1.35A 5i3bB-2p3xA:
21.4		 5i3bB-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A 243
HIS A 239
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.2A)
None
 1.00A 5i3bB-2p3xA:
21.4		 5i3bB-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A 243
HIS A 272
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.2A)
None
 0.85A 5i3bB-2p3xA:
21.4		 5i3bB-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 6 PRO A 153
GLU A  57
ALA A  65
LEU A 128
 None
 0.98A 5igiA-2p3xA:
undetectable		 5igiA-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 7 HIS A 243
ASP A 181
TYR A 182
HIS A 272
 C2O  A 340 (-3.3A)
None
None
C2O  A 340 (-3.1A)
 1.44A 5iy5A-2p3xA:
undetectable
5iy5C-2p3xA:
undetectable		 5iy5A-2p3xA:
19.17
5iy5C-2p3xA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 10 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.46A 5m8nA-2p3xA:
21.0		 5m8nA-2p3xA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 10 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.51A 5m8nB-2p3xA:
20.4		 5m8nB-2p3xA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 9 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.48A 5m8nC-2p3xA:
20.4		 5m8nC-2p3xA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 7 HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.35A 5m8rA-2p3xA:
20.4		 5m8rA-2p3xA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 8 HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.32A 5m8rB-2p3xA:
20.4		 5m8rB-2p3xA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 8 HIS A 108
HIS A 239
ASN A 240
HIS A 243
GLY A 257
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
None
 0.41A 5m8rC-2p3xA:
3.8		 5m8rC-2p3xA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 8 HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.30A 5m8rD-2p3xA:
20.4		 5m8rD-2p3xA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.86A 5mhwA-2p3xA:
undetectable		 5mhwA-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.86A 5mhxA-2p3xA:
undetectable		 5mhxA-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.86A 5mhyA-2p3xA:
undetectable		 5mhyA-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.86A 5mhzA-2p3xA:
undetectable		 5mhzA-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.85A 5mi1A-2p3xA:
undetectable		 5mi1A-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.85A 5mi2A-2p3xA:
undetectable		 5mi2A-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.85A 5miaA-2p3xA:
undetectable		 5miaA-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.85A 5mibA-2p3xA:
undetectable		 5mibA-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.85A 5micA-2p3xA:
undetectable		 5micA-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.85A 5midA-2p3xA:
undetectable		 5midA-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.85A 5mieA-2p3xA:
undetectable		 5mieA-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 HIS A 108
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.18A 5migA-2p3xA:
undetectable		 5migA-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 8 THR A 246
GLY A 247
GLY A 257
GLU A 254
 None
 0.70A 5vw9A-2p3xA:
undetectable		 5vw9A-2p3xA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 6 HIS A 243
ASP A 181
TYR A 182
HIS A 272
 C2O  A 340 (-3.3A)
None
None
C2O  A 340 (-3.1A)
 1.47A 5x1bN-2p3xA:
undetectable
5x1bP-2p3xA:
undetectable		 5x1bN-2p3xA:
19.17
5x1bP-2p3xA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.38A 5z0fA-2p3xA:
21.1
5z0fB-2p3xA:
undetectable		 5z0fA-2p3xA:
14.51
5z0fB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 117
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 1.49A 5z0fA-2p3xA:
21.1
5z0fB-2p3xA:
undetectable		 5z0fA-2p3xA:
14.51
5z0fB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 239
HIS A 243
HIS A  87
HIS A 108
PRO A  17
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
 1.18A 5z0fA-2p3xA:
21.1
5z0fB-2p3xA:
undetectable		 5z0fA-2p3xA:
14.51
5z0fB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 243
HIS A 239
HIS A 108
HIS A  87
VAL A  86
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
 1.11A 5z0fA-2p3xA:
21.1
5z0fB-2p3xA:
undetectable		 5z0fA-2p3xA:
14.51
5z0fB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.34A 5z0gA-2p3xA:
21.1
5z0gB-2p3xA:
undetectable		 5z0gA-2p3xA:
14.51
5z0gB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 239
HIS A 243
HIS A  87
HIS A 108
PRO A  17
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
 1.16A 5z0gA-2p3xA:
21.1
5z0gB-2p3xA:
undetectable		 5z0gA-2p3xA:
14.51
5z0gB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 243
HIS A 239
HIS A 108
HIS A  87
VAL A  86
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
 1.13A 5z0gA-2p3xA:
21.1
5z0gB-2p3xA:
undetectable		 5z0gA-2p3xA:
14.51
5z0gB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.37A 5z0hA-2p3xA:
21.1
5z0hB-2p3xA:
undetectable		 5z0hA-2p3xA:
14.51
5z0hB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 117
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 1.45A 5z0hA-2p3xA:
21.1
5z0hB-2p3xA:
undetectable		 5z0hA-2p3xA:
14.51
5z0hB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 239
HIS A 243
HIS A  87
HIS A 108
PRO A  17
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
 1.18A 5z0hA-2p3xA:
21.1
5z0hB-2p3xA:
undetectable		 5z0hA-2p3xA:
14.51
5z0hB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.36A 5z0iA-2p3xA:
21.1
5z0iB-2p3xA:
undetectable		 5z0iA-2p3xA:
14.51
5z0iB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 117
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 1.49A 5z0iA-2p3xA:
21.1
5z0iB-2p3xA:
undetectable		 5z0iA-2p3xA:
14.51
5z0iB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 239
HIS A 243
HIS A  87
HIS A 108
PRO A  17
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
 1.18A 5z0iA-2p3xA:
21.1
5z0iB-2p3xA:
undetectable		 5z0iA-2p3xA:
14.51
5z0iB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.37A 5z0jA-2p3xA:
21.1
5z0jB-2p3xA:
undetectable		 5z0jA-2p3xA:
14.51
5z0jB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 239
HIS A 243
HIS A  87
HIS A 108
PRO A  17
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
 1.16A 5z0jA-2p3xA:
21.1
5z0jB-2p3xA:
undetectable		 5z0jA-2p3xA:
14.51
5z0jB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.36A 5z0kA-2p3xA:
21.1
5z0kB-2p3xA:
undetectable		 5z0kA-2p3xA:
14.51
5z0kB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 239
HIS A 243
HIS A  87
HIS A 108
PRO A  17
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
 1.18A 5z0kA-2p3xA:
21.1
5z0kB-2p3xA:
undetectable		 5z0kA-2p3xA:
14.51
5z0kB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.36A 5z0lA-2p3xA:
21.1
5z0lB-2p3xA:
undetectable		 5z0lA-2p3xA:
14.51
5z0lB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 117
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 1.46A 5z0lA-2p3xA:
21.1
5z0lB-2p3xA:
undetectable		 5z0lA-2p3xA:
14.51
5z0lB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 239
HIS A 243
HIS A  87
HIS A 108
PRO A  17
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
 1.19A 5z0lA-2p3xA:
21.1
5z0lB-2p3xA:
undetectable		 5z0lA-2p3xA:
14.51
5z0lB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.44A 5z0mA-2p3xA:
21.1
5z0mB-2p3xA:
undetectable		 5z0mA-2p3xA:
13.58
5z0mB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 8 LEU A 128
PHE A 137
TYR A  58
LEU A 163
 None
 0.77A 5zcpN-2p3xA:
undetectable
5zcpW-2p3xA:
undetectable		 5zcpN-2p3xA:
19.17
5zcpW-2p3xA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 HIS A 239
HIS A 243
HIS A 272
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
 0.14A 5zrdA-2p3xA:
3.0		 5zrdA-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A 117
HIS A  87
PHE A 259
HIS A 108
 C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
C2O  A 340 (-4.2A)
C2O  A 340 (-3.3A)
 1.09A 5zrdB-2p3xA:
3.6		 5zrdB-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 5 HIS A 239
HIS A 243
PHE A 268
HIS A 271
HIS A 272
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 ( 4.7A)
None
C2O  A 340 (-3.1A)
 0.20A 5zrdB-2p3xA:
3.6		 5zrdB-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A  87
CYH A  91
HIS A 108
PHE A 268
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.6A)
C2O  A 340 (-3.3A)
C2O  A 340 ( 4.7A)
 1.17A 5zrdB-2p3xA:
3.6		 5zrdB-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A  87
HIS A 108
HIS A 117
PHE A 268
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.5A)
C2O  A 340 ( 4.7A)
 0.29A 5zrdB-2p3xA:
3.6		 5zrdB-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A 239
HIS A 243
HIS A 272
PHE A 113
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
None
 0.96A 5zrdB-2p3xA:
3.6		 5zrdB-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 239
HIS A 243
HIS A 271
HIS A 272
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
C2O  A 340 (-3.1A)
 0.17A 5zrdC-2p3xA:
3.1		 5zrdC-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A  87
CYH A  91
HIS A 108
PHE A 268
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.6A)
C2O  A 340 (-3.3A)
C2O  A 340 ( 4.7A)
 1.18A 5zrdC-2p3xA:
3.1		 5zrdC-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A  87
HIS A 108
HIS A 117
PHE A 268
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.5A)
C2O  A 340 ( 4.7A)
 0.24A 5zrdC-2p3xA:
3.1		 5zrdC-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A 239
HIS A 243
HIS A 272
PHE A 113
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
None
 1.01A 5zrdC-2p3xA:
3.1		 5zrdC-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A  87
CYH A  91
HIS A 108
PHE A 268
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.6A)
C2O  A 340 (-3.3A)
C2O  A 340 ( 4.7A)
 1.17A 5zrdD-2p3xA:
4.2		 5zrdD-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A  87
HIS A 108
HIS A 117
PHE A 268
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.5A)
C2O  A 340 ( 4.7A)
 0.35A 5zrdD-2p3xA:
4.2		 5zrdD-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A 239
HIS A 243
HIS A 272
PHE A 113
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
None
 0.98A 5zrdD-2p3xA:
4.2		 5zrdD-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 239
HIS A 243
HIS A 271
HIS A 272
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
C2O  A 340 (-3.1A)
 0.20A 5zrdD-2p3xA:
4.2		 5zrdD-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 ARG A  46
LYS A  61
ARG A 327
 None
 1.37A 6az3C-2p3xA:
undetectable
6az3L-2p3xA:
undetectable
6az3M-2p3xA:
undetectable		 6az3C-2p3xA:
12.93
6az3L-2p3xA:
13.44
6az3M-2p3xA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 6 LEU A 131
TYR A 122
GLN A  37
GLU A 308
 None
 1.34A 6djzC-2p3xA:
undetectable		 6djzC-2p3xA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 9 PRO A 153
MET A 150
LEU A 173
ASP A 191
LYS A 195
 None
 1.46A 6dm2A-2p3xA:
undetectable
6dm2D-2p3xA:
undetectable		 6dm2A-2p3xA:
13.57
6dm2D-2p3xA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 9 PRO A 153
MET A 150
LEU A 173
ASP A 191
LYS A 195
 None
 1.46A 6dm2B-2p3xA:
undetectable
6dm2C-2p3xA:
undetectable		 6dm2B-2p3xA:
13.57
6dm2C-2p3xA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 TYR A 120
HIS A 117
PHE A 268
 None
C2O  A 340 (-3.5A)
C2O  A 340 ( 4.7A)
 1.06A 6esmA-2p3xA:
undetectable		 6esmA-2p3xA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 HIS A 239
HIS A 272
HIS A 271
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.1A)
None
 0.73A 6giqa-2p3xA:
undetectable		 6giqa-2p3xA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 TYR A 120
VAL A  29
PHE A  80
GLY A 263
 None
 1.09A 6hd4A-2p3xA:
undetectable		 6hd4A-2p3xA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 6 TYR A 120
VAL A  29
PHE A  80
GLY A 263
 None
 1.04A 6hd4B-2p3xA:
undetectable		 6hd4B-2p3xA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 HIS A 239
HIS A 272
HIS A 271
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.1A)
None
 0.74A 6hu9a-2p3xA:
0.5		 6hu9a-2p3xA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 6 HIS A 243
ASP A 181
TYR A 182
HIS A 272
 C2O  A 340 (-3.3A)
None
None
C2O  A 340 (-3.1A)
 1.48A 6nmpA-2p3xA:
undetectable
6nmpC-2p3xA:
undetectable		 6nmpA-2p3xA:
19.17
6nmpC-2p3xA:
19.65