SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p4b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB
(Escherichia
coli) 		4 / 6 TYR A 254
VAL A 265
ILE A 294
LEU A 300
 None
 1.21A 1j96A-2p4bA:
undetectable		 1j96A-2p4bA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB
(Escherichia
coli) 		4 / 9 ILE A 136
ARG A 139
ALA A 187
VAL A 185
 None
 0.95A 2vufB-2p4bA:
undetectable		 2vufB-2p4bA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB
(Escherichia
coli) 		5 / 12 LEU A 206
PHE A  93
ARG A  80
ILE A  90
THR A 200
 None
 1.09A 2w3bA-2p4bA:
undetectable		 2w3bA-2p4bA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB
(Escherichia
coli) 		4 / 7 ILE A 312
VAL A 263
ARG A 252
TYR A 254
 None
 1.09A 3p6hA-2p4bA:
3.2		 3p6hA-2p4bA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ID5_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB
(Escherichia
coli) 		5 / 12 LEU A  31
VAL A 170
TYR A 156
PRO A 112
PRO A 167
 None
 1.22A 4id5A-2p4bA:
undetectable		 4id5A-2p4bA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFY_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB
(Escherichia
coli) 		5 / 12 LEU A  31
VAL A 170
TYR A 156
PRO A 112
PRO A 167
 None
 1.18A 4ifyA-2p4bA:
1.2		 4ifyA-2p4bA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG3_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB
(Escherichia
coli) 		5 / 12 LEU A  31
VAL A 170
TYR A 156
PRO A 112
PRO A 167
 None
 1.23A 4ig3A-2p4bA:
1.4		 4ig3A-2p4bA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)		 2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB
(Escherichia
coli) 		5 / 12 LEU A  31
VAL A 170
TYR A 156
PRO A 112
PRO A 167
 None
 1.20A 4kfbA-2p4bA:
undetectable		 4kfbA-2p4bA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB
(Escherichia
coli) 		3 / 3 GLY A  78
PRO A  79
GLN A  75
 None
 0.24A 4oltB-2p4bA:
undetectable		 4oltB-2p4bA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB
(Escherichia
coli) 		3 / 3 GLY A  78
PRO A  79
GLN A  75
 None
 0.32A 4qwpB-2p4bA:
undetectable		 4qwpB-2p4bA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB
(Escherichia
coli) 		5 / 12 PHE A 128
ARG A 153
TYR A 156
LEU A 258
LEU A  31
 None
 1.38A 4qztC-2p4bA:
2.2		 4qztC-2p4bA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB
(Escherichia
coli) 		3 / 3 ARG A 153
ASP A 150
TYR A 125
 None
 0.84A 4yo9B-2p4bA:
1.8		 4yo9B-2p4bA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB
(Escherichia
coli) 		4 / 5 TYR A 116
LEU A  45
PRO A 167
LEU A  73
 None
 1.11A 5eshA-2p4bA:
undetectable		 5eshA-2p4bA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB
(Escherichia
coli) 		4 / 6 ASP A 193
ASP A  66
ARG A  64
ASN A  42
 None
 1.16A 5l6eA-2p4bA:
undetectable		 5l6eA-2p4bA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB
(Escherichia
coli) 		4 / 5 ILE A 296
PHE A 261
ARG A 307
THR A 225
 None
 1.15A 5z84N-2p4bA:
undetectable
5z84W-2p4bA:
undetectable		 5z84N-2p4bA:
17.90
5z84W-2p4bA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB
(Escherichia
coli) 		4 / 8 ASP A 138
ARG A 139
ASP A 161
GLU A 163
 None
 1.21A 6mn4A-2p4bA:
undetectable		 6mn4A-2p4bA:
23.17