SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DDS_A_MTXA201_1 (DIHYDROFOLATE REDUCTASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	ILE A 38 ASP A 61 THR A 81 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 278 (-3.2A) EDO A 284 ( 3.5A) EDO A 280 (-4.3A) None	0.66A	1ddsA-2p4gA: 15.1	1ddsA-2p4gA: 21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DDS_B_MTXB201_1 (DIHYDROFOLATE REDUCTASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	ILE A 38 ASP A 61 ARG A 69 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 278 (-3.2A) EDO A 275 (-2.8A) EDO A 280 (-4.3A) None	1.18A	1ddsB-2p4gA: 15.2	1ddsB-2p4gA: 21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DHF_B_FOLB187_0 (DIHYDROFOLATE REDUCTASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	ILE A 38 THR A 81 ARG A 69 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 284 ( 3.5A) EDO A 275 (-2.8A) EDO A 280 (-4.3A) None	1.07A	1dhfB-2p4gA: 13.8	1dhfB-2p4gA: 20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DYI_A_FOLA161_0 (DIHYDROFOLATE REDUCTASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	ILE A 38 ASP A 61 THR A 81 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 278 (-3.2A) EDO A 284 ( 3.5A) EDO A 280 (-4.3A) None	0.56A	1dyiA-2p4gA: 14.9	1dyiA-2p4gA: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DYI_B_FOLB161_0 (DIHYDROFOLATE REDUCTASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	ILE A 38 ASP A 61 THR A 81 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 278 (-3.2A) EDO A 284 ( 3.5A) EDO A 280 (-4.3A) None	0.57A	1dyiB-2p4gA: 14.9	1dyiB-2p4gA: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RD7_B_FOLB361_0 (DIHYDROFOLATE REDUCTASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	ILE A 38 ASP A 61 THR A 81 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 278 (-3.2A) EDO A 284 ( 3.5A) EDO A 280 (-4.3A) None	0.63A	1rd7B-2p4gA: 14.7	1rd7B-2p4gA: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RE7_A_FOLA161_0 (DIHYDROFOLATE REDUCTASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	ILE A 38 ASP A 61 THR A 81 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 278 (-3.2A) EDO A 284 ( 3.5A) EDO A 280 (-4.3A) None	0.56A	1re7A-2p4gA: 14.7	1re7A-2p4gA: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RX7_A_FOLA161_0 (DIHYDROFOLATE REDUCTASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	ILE A 38 ASP A 61 THR A 81 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 278 (-3.2A) EDO A 284 ( 3.5A) EDO A 280 (-4.3A) None	0.61A	1rx7A-2p4gA: 14.6	1rx7A-2p4gA: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A1H_B_GBNB501_1 (BRANCHED CHAIN AMINOTRANSFERASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	4 / 8	VAL A 90 GLY A 78 THR A 81 ALA A 82	EDO A 275 ( 4.4A) EDO A 282 ( 3.4A) EDO A 284 ( 3.5A) EDO A 276 ( 3.7A)	0.82A	2a1hA-2p4gA: undetectable 2a1hB-2p4gA: undetectable	2a1hA-2p4gA: 20.81 2a1hB-2p4gA: 20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CD2_A_FOLA307_0 (DIHYDROFOLATE REDUCTASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	ILE A 38 THR A 81 ARG A 69 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 284 ( 3.5A) EDO A 275 (-2.8A) EDO A 280 (-4.3A) None	1.05A	2cd2A-2p4gA: 13.8	2cd2A-2p4gA: 21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W9S_E_TOPE1160_1 (DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	4 / 8	ILE A 38 ASP A 61 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 278 (-3.2A) EDO A 280 (-4.3A) None	0.46A	2w9sE-2p4gA: 15.1	2w9sE-2p4gA: 20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FPJ_A_SAMA301_0 (PUTATIVE UNCHARACTERIZED PROTEIN)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	ILE A 75 VAL A 77 ILE A 140 ALA A 74 VAL A 90	None None None None EDO A 275 ( 4.4A)	0.90A	3fpjA-2p4gA: 2.6	3fpjA-2p4gA: 22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3I5U_A_SAMA401_0 (O-METHYLTRANSFERASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	LEU A 227 GLY A 194 GLY A 195 LEU A 114 ALA A 37	None EDO A 280 ( 4.1A) EDO A 272 ( 3.1A) None None	1.22A	3i5uA-2p4gA: undetectable	3i5uA-2p4gA: 22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JUS_B_ECLB600_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 8	THR A 81 TYR A 87 GLY A 54 THR A 214 ILE A 38	EDO A 284 ( 3.5A) EDO A 271 ( 4.0A) None None EDO A 278 (-4.7A)	1.34A	3jusB-2p4gA: undetectable	3jusB-2p4gA: 21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JUS_B_ECNB602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 9	THR A 81 TYR A 87 GLY A 54 THR A 214 ILE A 38	EDO A 284 ( 3.5A) EDO A 271 ( 4.0A) None None EDO A 278 (-4.7A)	1.34A	3jusB-2p4gA: undetectable	3jusB-2p4gA: 21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KP3_B_AICB2002_1 (TRANSCRIPTIONAL REGULATOR TCAR)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	3 / 3	ALA A 184 ARG A 185 LYS A 110	None None EDO A 285 (-3.8A)	0.98A	3kp3B-2p4gA: undetectable	3kp3B-2p4gA: 21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MBH_F_PXLF400_1 (PUTATIVE PHOSPHOMETHYLPYRIMID INE KINASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 11	ASP A 58 SER A 248 LEU A 252 THR A 214 ASP A 63	None	1.25A	3mbhF-2p4gA: undetectable	3mbhF-2p4gA: 23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUD_A_SUEA1201_1 (NS3 PROTEASE, NS4A PROTEIN)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	GLY A 229 GLY A 45 ALA A 47 ALA A 39 SER A 255	None None EDO A 280 ( 3.7A) EDO A 280 (-3.5A) None	1.10A	3sudA-2p4gA: undetectable	3sudA-2p4gA: 22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UM5_A_CP6A609_1 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 10	ILE A 38 ASP A 61 THR A 81 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 278 (-3.2A) EDO A 284 ( 3.5A) EDO A 280 (-4.3A) None	0.55A	3um5A-2p4gA: 14.6	3um5A-2p4gA: 18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UM5_B_CP6B709_1 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 10	ILE A 38 ASP A 61 THR A 81 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 278 (-3.2A) EDO A 284 ( 3.5A) EDO A 280 (-4.3A) None	0.63A	3um5B-2p4gA: 14.2	3um5B-2p4gA: 18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CD2_A_FOLA207_0 (DIHYDROFOLATE REDUCTASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	ILE A 38 THR A 81 ARG A 69 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 284 ( 3.5A) EDO A 275 (-2.8A) EDO A 280 (-4.3A) None	1.00A	4cd2A-2p4gA: 13.7	4cd2A-2p4gA: 21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DT8_A_ADNA401_1 (APH(2'')-ID)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 11	GLY A 70 ALA A 72 ILE A 75 HIS A 212 ILE A 38	EDO A 279 (-4.9A) None None None EDO A 278 (-4.7A)	0.94A	4dt8A-2p4gA: undetectable	4dt8A-2p4gA: 20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KM0_A_CP6A201_1 (DIHYDROFOLATE REDUCTASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 10	ILE A 38 ASP A 61 THR A 81 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 278 (-3.2A) EDO A 284 ( 3.5A) EDO A 280 (-4.3A) None	0.81A	4km0A-2p4gA: 14.1	4km0A-2p4gA: 22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KM0_B_CP6B201_1 (DIHYDROFOLATE REDUCTASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	ILE A 38 ASP A 61 THR A 81 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 278 (-3.2A) EDO A 284 ( 3.5A) EDO A 280 (-4.3A) None	0.76A	4km0B-2p4gA: 14.5	4km0B-2p4gA: 22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PTH_A_FOLA201_0 (DIHYDROFOLATE REDUCTASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	ILE A 38 THR A 81 ARG A 69 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 284 ( 3.5A) EDO A 275 (-2.8A) EDO A 280 (-4.3A) None	1.05A	4pthA-2p4gA: 15.5	4pthA-2p4gA: 21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QGI_A_ROCA101_1 (PROTEASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 11	GLY A 251 ASP A 61 ILE A 40 THR A 41 ILE A 43	None EDO A 278 (-3.2A) EDO A 278 ( 3.9A) None None	0.95A	4qgiA-2p4gA: undetectable	4qgiA-2p4gA: 17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QLE_A_FOLA201_0 (DIHYDROFOLATE REDUCTASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	ILE A 38 ASP A 61 THR A 81 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 278 (-3.2A) EDO A 284 ( 3.5A) EDO A 280 (-4.3A) None	0.57A	4qleA-2p4gA: 14.9	4qleA-2p4gA: 21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QLG_B_FOLB201_0 (DIHYDROFOLATE REDUCTASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	ILE A 38 ASP A 61 THR A 81 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 278 (-3.2A) EDO A 284 ( 3.5A) EDO A 280 (-4.3A) None	0.51A	4qlgB-2p4gA: 14.7	4qlgB-2p4gA: 19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QLG_B_FOLB201_0 (DIHYDROFOLATE REDUCTASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	ILE A 38 THR A 81 ARG A 69 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 284 ( 3.5A) EDO A 275 (-2.8A) EDO A 280 (-4.3A) None	1.08A	4qlgB-2p4gA: 14.7	4qlgB-2p4gA: 19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X5F_A_FOLA201_0 (DIHYDROFOLATE REDUCTASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	ILE A 38 THR A 81 ARG A 69 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 284 ( 3.5A) EDO A 275 (-2.8A) EDO A 280 (-4.3A) None	1.07A	4x5fA-2p4gA: 14.7	4x5fA-2p4gA: 21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X5G_A_FOLA201_0 (DIHYDROFOLATE REDUCTASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	ILE A 38 ASP A 61 THR A 81 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 278 (-3.2A) EDO A 284 ( 3.5A) EDO A 280 (-4.3A) None	0.52A	4x5gA-2p4gA: 14.6	4x5gA-2p4gA: 21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4XT7_A_TOPA302_1 (RV2671)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	6 / 11	ILE A 40 SER A 53 GLY A 54 ASP A 61 GLU A 85 THR A 214	EDO A 278 ( 3.9A) EDO A 280 ( 3.1A) None EDO A 278 (-3.2A) EDO A 284 ( 3.8A) None	0.94A	4xt7A-2p4gA: 27.2	4xt7A-2p4gA: 31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4XT7_A_TOPA302_1 (RV2671)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	6 / 11	ILE A 40 SER A 53 GLY A 54 ASP A 61 GLU A 193 THR A 214	EDO A 278 ( 3.9A) EDO A 280 ( 3.1A) None EDO A 278 (-3.2A) None None	0.68A	4xt7A-2p4gA: 27.2	4xt7A-2p4gA: 31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4XT8_A_TMQA302_1 (RV2671)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	8 / 12	ILE A 40 GLY A 54 ASP A 61 ARG A 69 GLU A 85 TYR A 87 GLU A 193 THR A 214	EDO A 278 ( 3.9A) None EDO A 278 (-3.2A) EDO A 275 (-2.8A) EDO A 284 ( 3.8A) EDO A 271 ( 4.0A) None None	0.66A	4xt8A-2p4gA: 27.2	4xt8A-2p4gA: 31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4XT8_A_TMQA302_1 (RV2671)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	8 / 12	ILE A 40 SER A 53 GLY A 54 ASP A 61 GLU A 85 TYR A 87 GLU A 193 THR A 214	EDO A 278 ( 3.9A) EDO A 280 ( 3.1A) None EDO A 278 (-3.2A) EDO A 284 ( 3.8A) EDO A 271 ( 4.0A) None None	0.78A	4xt8A-2p4gA: 27.2	4xt8A-2p4gA: 31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZBR_A_ACTA608_0 (SERUM ALBUMIN)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	3 / 3	LYS A 258 ARG A 256 HIS A 212	None	0.86A	4zbrA-2p4gA: undetectable	4zbrA-2p4gA: 18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L0Z_A_SAMA304_0 (PROBABLE RNA METHYLTRANSFERASE, TRMH FAMILY)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	THR A 112 GLY A 78 ILE A 166 LEU A 175 ALA A 178	None EDO A 282 ( 3.4A) None None None	0.97A	5l0zA-2p4gA: undetectable	5l0zA-2p4gA: 23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NY7_A_NCAA303_0 (AMIDASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	4 / 6	GLY A 195 PRO A 196 THR A 81 SER A 53	EDO A 272 ( 3.1A) EDO A 272 ( 3.8A) EDO A 284 ( 3.5A) EDO A 280 ( 3.1A)	1.01A	5ny7A-2p4gA: undetectable	5ny7A-2p4gA: 22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UIH_A_8CVA201_1 (DIHYDROFOLATE REDUCTASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	4 / 8	ILE A 38 ASP A 61 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 278 (-3.2A) EDO A 280 (-4.3A) None	0.43A	5uihA-2p4gA: 15.2	5uihA-2p4gA: 13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UIH_A_8CVA201_1 (DIHYDROFOLATE REDUCTASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	4 / 8	ILE A 190 ALA A 72 LEU A 111 ILE A 192	None	0.85A	5uihA-2p4gA: 15.2	5uihA-2p4gA: 13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UJX_B_FOLB201_0 (DIHYDROFOLATE REDUCTASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 12	ILE A 38 THR A 81 ARG A 69 TYR A 199 THR A 214	EDO A 278 (-4.7A) EDO A 284 ( 3.5A) EDO A 275 (-2.8A) EDO A 280 (-4.3A) None	1.02A	5ujxB-2p4gA: 14.8	5ujxB-2p4gA: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6R2E_C_FFOC404_0 (THYMIDYLATE SYNTHASE)	2p4g	HYPOTHETICAL PROTEIN (Corynebacterium diphtheriae)	5 / 10	ILE A 215 LEU A 49 LEU A 227 GLY A 45 ASN A 44	None	1.40A	6r2eC-2p4gA: undetectable	6r2eC-2p4gA: 20.81

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DDS_A_MTXA201_1","DIHYDROFOLATE REDUCTASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  38;ASP A  61;THR A  81;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 278 (-3.2A);EDO A 284 ( 3.5A);EDO A 280 (-4.3A);None","0.66A","1ddsA-2p4gA:15.1","1ddsA-2p4gA:21.59"],["1DDS_B_MTXB201_1","DIHYDROFOLATE REDUCTASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  38;ASP A  61;ARG A  69;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 278 (-3.2A);EDO A 275 (-2.8A);EDO A 280 (-4.3A);None","1.18A","1ddsB-2p4gA:15.2","1ddsB-2p4gA:21.59"],["1DHF_B_FOLB187_0","DIHYDROFOLATE REDUCTASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  38;THR A  81;ARG A  69;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 284 ( 3.5A);EDO A 275 (-2.8A);EDO A 280 (-4.3A);None","1.07A","1dhfB-2p4gA:13.8","1dhfB-2p4gA:20.44"],["1DYI_A_FOLA161_0","DIHYDROFOLATE REDUCTASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  38;ASP A  61;THR A  81;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 278 (-3.2A);EDO A 284 ( 3.5A);EDO A 280 (-4.3A);None","0.56A","1dyiA-2p4gA:14.9","1dyiA-2p4gA:21.97"],["1DYI_B_FOLB161_0","DIHYDROFOLATE REDUCTASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  38;ASP A  61;THR A  81;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 278 (-3.2A);EDO A 284 ( 3.5A);EDO A 280 (-4.3A);None","0.57A","1dyiB-2p4gA:14.9","1dyiB-2p4gA:21.97"],["1RD7_B_FOLB361_0","DIHYDROFOLATE REDUCTASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  38;ASP A  61;THR A  81;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 278 (-3.2A);EDO A 284 ( 3.5A);EDO A 280 (-4.3A);None","0.63A","1rd7B-2p4gA:14.7","1rd7B-2p4gA:21.97"],["1RE7_A_FOLA161_0","DIHYDROFOLATE REDUCTASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  38;ASP A  61;THR A  81;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 278 (-3.2A);EDO A 284 ( 3.5A);EDO A 280 (-4.3A);None","0.56A","1re7A-2p4gA:14.7","1re7A-2p4gA:21.97"],["1RX7_A_FOLA161_0","DIHYDROFOLATE REDUCTASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  38;ASP A  61;THR A  81;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 278 (-3.2A);EDO A 284 ( 3.5A);EDO A 280 (-4.3A);None","0.61A","1rx7A-2p4gA:14.6","1rx7A-2p4gA:21.97"],["2A1H_B_GBNB501_1","BRANCHED CHAIN AMINOTRANSFERASE;BRANCHED CHAIN AMINOTRANSFERASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",4,"VAL A  90;GLY A  78;THR A  81;ALA A  82","EDO A 275 ( 4.4A);EDO A 282 ( 3.4A);EDO A 284 ( 3.5A);EDO A 276 ( 3.7A)","0.82A","2a1hA-2p4gA:undetectable;2a1hB-2p4gA:undetectable","2a1hA-2p4gA:20.81;2a1hB-2p4gA:20.81"],["2CD2_A_FOLA307_0","DIHYDROFOLATE REDUCTASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  38;THR A  81;ARG A  69;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 284 ( 3.5A);EDO A 275 (-2.8A);EDO A 280 (-4.3A);None","1.05A","2cd2A-2p4gA:13.8","2cd2A-2p4gA:21.35"],["2W9S_E_TOPE1160_1","DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",4,"ILE A  38;ASP A  61;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 278 (-3.2A);EDO A 280 (-4.3A);None","0.46A","2w9sE-2p4gA:15.1","2w9sE-2p4gA:20.73"],["3FPJ_A_SAMA301_0","PUTATIVE UNCHARACTERIZED PROTEIN","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  75;VAL A  77;ILE A 140;ALA A  74;VAL A  90","None;None;None;None;EDO A 275 ( 4.4A)","0.90A","3fpjA-2p4gA:2.6","3fpjA-2p4gA:22.50"],["3I5U_A_SAMA401_0","O-METHYLTRANSFERASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"LEU A 227;GLY A 194;GLY A 195;LEU A 114;ALA A  37","None;EDO A 280 ( 4.1A);EDO A 272 ( 3.1A);None;None","1.22A","3i5uA-2p4gA:undetectable","3i5uA-2p4gA:22.66"],["3JUS_B_ECLB600_1","LANOSTEROL 14-ALPHA DEMETHYLASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"THR A  81;TYR A  87;GLY A  54;THR A 214;ILE A  38","EDO A 284 ( 3.5A);EDO A 271 ( 4.0A);None;None;EDO A 278 (-4.7A)","1.34A","3jusB-2p4gA:undetectable","3jusB-2p4gA:21.63"],["3JUS_B_ECNB602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"THR A  81;TYR A  87;GLY A  54;THR A 214;ILE A  38","EDO A 284 ( 3.5A);EDO A 271 ( 4.0A);None;None;EDO A 278 (-4.7A)","1.34A","3jusB-2p4gA:undetectable","3jusB-2p4gA:21.63"],["3KP3_B_AICB2002_1","TRANSCRIPTIONAL REGULATOR TCAR","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",3,"ALA A 184;ARG A 185;LYS A 110","None;None;EDO A 285 (-3.8A)","0.98A","3kp3B-2p4gA:undetectable","3kp3B-2p4gA:21.51"],["3MBH_F_PXLF400_1","PUTATIVE PHOSPHOMETHYLPYRIMIDINE KINASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ASP A  58;SER A 248;LEU A 252;THR A 214;ASP A  63","None","1.25A","3mbhF-2p4gA:undetectable","3mbhF-2p4gA:23.87"],["3SUD_A_SUEA1201_1","NS3 PROTEASE, NS4A PROTEIN","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"GLY A 229;GLY A  45;ALA A  47;ALA A  39;SER A 255","None;None;EDO A 280 ( 3.7A);EDO A 280 (-3.5A);None","1.10A","3sudA-2p4gA:undetectable","3sudA-2p4gA:22.69"],["3UM5_A_CP6A609_1","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  38;ASP A  61;THR A  81;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 278 (-3.2A);EDO A 284 ( 3.5A);EDO A 280 (-4.3A);None","0.55A","3um5A-2p4gA:14.6","3um5A-2p4gA:18.49"],["3UM5_B_CP6B709_1","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  38;ASP A  61;THR A  81;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 278 (-3.2A);EDO A 284 ( 3.5A);EDO A 280 (-4.3A);None","0.63A","3um5B-2p4gA:14.2","3um5B-2p4gA:18.49"],["4CD2_A_FOLA207_0","DIHYDROFOLATE REDUCTASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  38;THR A  81;ARG A  69;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 284 ( 3.5A);EDO A 275 (-2.8A);EDO A 280 (-4.3A);None","1.00A","4cd2A-2p4gA:13.7","4cd2A-2p4gA:21.35"],["4DT8_A_ADNA401_1","APH(2'')-ID","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"GLY A  70;ALA A  72;ILE A  75;HIS A 212;ILE A  38","EDO A 279 (-4.9A);None;None;None;EDO A 278 (-4.7A)","0.94A","4dt8A-2p4gA:undetectable","4dt8A-2p4gA:20.43"],["4KM0_A_CP6A201_1","DIHYDROFOLATE REDUCTASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  38;ASP A  61;THR A  81;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 278 (-3.2A);EDO A 284 ( 3.5A);EDO A 280 (-4.3A);None","0.81A","4km0A-2p4gA:14.1","4km0A-2p4gA:22.90"],["4KM0_B_CP6B201_1","DIHYDROFOLATE REDUCTASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  38;ASP A  61;THR A  81;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 278 (-3.2A);EDO A 284 ( 3.5A);EDO A 280 (-4.3A);None","0.76A","4km0B-2p4gA:14.5","4km0B-2p4gA:22.90"],["4PTH_A_FOLA201_0","DIHYDROFOLATE REDUCTASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  38;THR A  81;ARG A  69;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 284 ( 3.5A);EDO A 275 (-2.8A);EDO A 280 (-4.3A);None","1.05A","4pthA-2p4gA:15.5","4pthA-2p4gA:21.59"],["4QGI_A_ROCA101_1","PROTEASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"GLY A 251;ASP A  61;ILE A  40;THR A  41;ILE A  43","None;EDO A 278 (-3.2A);EDO A 278 ( 3.9A);None;None","0.95A","4qgiA-2p4gA:undetectable","4qgiA-2p4gA:17.15"],["4QLE_A_FOLA201_0","DIHYDROFOLATE REDUCTASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  38;ASP A  61;THR A  81;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 278 (-3.2A);EDO A 284 ( 3.5A);EDO A 280 (-4.3A);None","0.57A","4qleA-2p4gA:14.9","4qleA-2p4gA:21.27"],["4QLG_B_FOLB201_0","DIHYDROFOLATE REDUCTASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  38;ASP A  61;THR A  81;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 278 (-3.2A);EDO A 284 ( 3.5A);EDO A 280 (-4.3A);None","0.51A","4qlgB-2p4gA:14.7","4qlgB-2p4gA:19.48"],["4QLG_B_FOLB201_0","DIHYDROFOLATE REDUCTASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  38;THR A  81;ARG A  69;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 284 ( 3.5A);EDO A 275 (-2.8A);EDO A 280 (-4.3A);None","1.08A","4qlgB-2p4gA:14.7","4qlgB-2p4gA:19.48"],["4X5F_A_FOLA201_0","DIHYDROFOLATE REDUCTASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  38;THR A  81;ARG A  69;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 284 ( 3.5A);EDO A 275 (-2.8A);EDO A 280 (-4.3A);None","1.07A","4x5fA-2p4gA:14.7","4x5fA-2p4gA:21.93"],["4X5G_A_FOLA201_0","DIHYDROFOLATE REDUCTASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  38;ASP A  61;THR A  81;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 278 (-3.2A);EDO A 284 ( 3.5A);EDO A 280 (-4.3A);None","0.52A","4x5gA-2p4gA:14.6","4x5gA-2p4gA:21.93"],["4XT7_A_TOPA302_1","RV2671","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",6,"ILE A  40;SER A  53;GLY A  54;ASP A  61;GLU A  85;THR A 214","EDO A 278 ( 3.9A);EDO A 280 ( 3.1A);None;EDO A 278 (-3.2A);EDO A 284 ( 3.8A);None","0.94A","4xt7A-2p4gA:27.2","4xt7A-2p4gA:31.43"],["4XT7_A_TOPA302_1","RV2671","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",6,"ILE A  40;SER A  53;GLY A  54;ASP A  61;GLU A 193;THR A 214","EDO A 278 ( 3.9A);EDO A 280 ( 3.1A);None;EDO A 278 (-3.2A);None;None","0.68A","4xt7A-2p4gA:27.2","4xt7A-2p4gA:31.43"],["4XT8_A_TMQA302_1","RV2671","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",8,"ILE A  40;GLY A  54;ASP A  61;ARG A  69;GLU A  85;TYR A  87;GLU A 193;THR A 214","EDO A 278 ( 3.9A);None;EDO A 278 (-3.2A);EDO A 275 (-2.8A);EDO A 284 ( 3.8A);EDO A 271 ( 4.0A);None;None","0.66A","4xt8A-2p4gA:27.2","4xt8A-2p4gA:31.43"],["4XT8_A_TMQA302_1","RV2671","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",8,"ILE A  40;SER A  53;GLY A  54;ASP A  61;GLU A  85;TYR A  87;GLU A 193;THR A 214","EDO A 278 ( 3.9A);EDO A 280 ( 3.1A);None;EDO A 278 (-3.2A);EDO A 284 ( 3.8A);EDO A 271 ( 4.0A);None;None","0.78A","4xt8A-2p4gA:27.2","4xt8A-2p4gA:31.43"],["4ZBR_A_ACTA608_0","SERUM ALBUMIN","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",3,"LYS A 258;ARG A 256;HIS A 212","None","0.86A","4zbrA-2p4gA:undetectable","4zbrA-2p4gA:18.66"],["5L0Z_A_SAMA304_0","PROBABLE RNA METHYLTRANSFERASE, TRMH FAMILY","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"THR A 112;GLY A  78;ILE A 166;LEU A 175;ALA A 178","None;EDO A 282 ( 3.4A);None;None;None","0.97A","5l0zA-2p4gA:undetectable","5l0zA-2p4gA:23.73"],["5NY7_A_NCAA303_0","AMIDASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",4,"GLY A 195;PRO A 196;THR A  81;SER A  53","EDO A 272 ( 3.1A);EDO A 272 ( 3.8A);EDO A 284 ( 3.5A);EDO A 280 ( 3.1A)","1.01A","5ny7A-2p4gA:undetectable","5ny7A-2p4gA:22.59"],["5UIH_A_8CVA201_1","DIHYDROFOLATE REDUCTASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",4,"ILE A  38;ASP A  61;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 278 (-3.2A);EDO A 280 (-4.3A);None","0.43A","5uihA-2p4gA:15.2","5uihA-2p4gA:13.91"],["5UIH_A_8CVA201_1","DIHYDROFOLATE REDUCTASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",4,"ILE A 190;ALA A  72;LEU A 111;ILE A 192","None","0.85A","5uihA-2p4gA:15.2","5uihA-2p4gA:13.91"],["5UJX_B_FOLB201_0","DIHYDROFOLATE REDUCTASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A  38;THR A  81;ARG A  69;TYR A 199;THR A 214","EDO A 278 (-4.7A);EDO A 284 ( 3.5A);EDO A 275 (-2.8A);EDO A 280 (-4.3A);None","1.02A","5ujxB-2p4gA:14.8","5ujxB-2p4gA:21.97"],["6R2E_C_FFOC404_0","THYMIDYLATE SYNTHASE","2p4g","HYPOTHETICAL PROTEIN","Corynebacterium diphtheriae",5,"ILE A 215;LEU A  49;LEU A 227;GLY A  45;ASN A  44","None","1.40A","6r2eC-2p4gA:undetectable","6r2eC-2p4gA:20.81"]]