SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p4h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 2p4h VESTITONE REDUCTASE
(Medicago
sativa) 		5 / 12 GLY X  81
ASP X 185
VAL X 187
ILE X 239
THR X 127
 None
 0.97A 1c6zA-2p4hX:
undetectable		 1c6zA-2p4hX:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2p4h VESTITONE REDUCTASE
(Medicago
sativa) 		4 / 7 GLY X  18
THR X 127
THR X  85
ILE X  21
 None
 0.86A 1gtnC-2p4hX:
undetectable
1gtnD-2p4hX:
undetectable		 1gtnC-2p4hX:
15.70
1gtnD-2p4hX:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2p4h VESTITONE REDUCTASE
(Medicago
sativa) 		4 / 6 GLY X  18
THR X 127
THR X  85
ILE X  21
 None
 0.89A 1gtnD-2p4hX:
undetectable
1gtnE-2p4hX:
undetectable		 1gtnD-2p4hX:
15.70
1gtnE-2p4hX:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2p4h VESTITONE REDUCTASE
(Medicago
sativa) 		4 / 7 GLY X  18
THR X 127
THR X  85
ILE X  21
 None
 0.89A 1gtnF-2p4hX:
undetectable
1gtnG-2p4hX:
undetectable		 1gtnF-2p4hX:
15.70
1gtnG-2p4hX:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2p4h VESTITONE REDUCTASE
(Medicago
sativa) 		4 / 7 GLY X  18
THR X 127
THR X  85
ILE X  21
 None
 0.90A 1gtnJ-2p4hX:
undetectable
1gtnK-2p4hX:
undetectable		 1gtnJ-2p4hX:
15.70
1gtnK-2p4hX:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2p4h VESTITONE REDUCTASE
(Medicago
sativa) 		4 / 7 LEU X 241
ILE X 125
ALA X 237
ILE X 194
 None
 0.99A 1oniB-2p4hX:
undetectable
1oniC-2p4hX:
undetectable		 1oniB-2p4hX:
19.74
1oniC-2p4hX:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 2p4h VESTITONE REDUCTASE
(Medicago
sativa) 		3 / 3 TRP X 148
LEU X 143
LYS X 140
 None
 1.10A 1yajK-2p4hX:
4.2		 1yajK-2p4hX:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 2p4h VESTITONE REDUCTASE
(Medicago
sativa) 		3 / 3 ASP X 233
PHE X 303
ARG X 236
 None
 0.86A 2a3aA-2p4hX:
2.1		 2a3aA-2p4hX:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2p4h VESTITONE REDUCTASE
(Medicago
sativa) 		3 / 3 SER X  24
ASP X 233
CYH X 253
 None
 0.75A 2br4E-2p4hX:
4.1		 2br4E-2p4hX:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 2p4h VESTITONE REDUCTASE
(Medicago
sativa) 		4 / 4 LEU X 293
PRO X 291
LEU X 143
ARG X 250
 None
 1.30A 2qd2A-2p4hX:
2.4		 2qd2A-2p4hX:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2p4h VESTITONE REDUCTASE
(Medicago
sativa) 		5 / 12 ILE X  21
ILE X  22
LEU X  25
THR X  35
VAL X  32
 None
 0.78A 3rukB-2p4hX:
undetectable		 3rukB-2p4hX:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2p4h VESTITONE REDUCTASE
(Medicago
sativa) 		4 / 7 SER X 134
SER X 131
PHE X 193
LEU X 290
 None
 0.80A 3v7pA-2p4hX:
2.8		 3v7pA-2p4hX:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2p4h VESTITONE REDUCTASE
(Medicago
sativa) 		4 / 7 GLU X 261
GLU X 262
HIS X 227
VAL X 195
 None
 1.04A 4a97A-2p4hX:
undetectable		 4a97A-2p4hX:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2p4h VESTITONE REDUCTASE
(Medicago
sativa) 		4 / 8 SER X  71
ILE X 184
VAL X 186
PHE X 124
 None
 0.89A 4dx7B-2p4hX:
undetectable		 4dx7B-2p4hX:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2p4h VESTITONE REDUCTASE
(Medicago
sativa) 		4 / 4 PRO X 291
LEU X 293
ILE X 190
ARG X 250
 None
 1.50A 4f4dA-2p4hX:
2.7		 4f4dA-2p4hX:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2p4h VESTITONE REDUCTASE
(Medicago
sativa) 		4 / 8 VAL X 105
LEU X 109
ILE X 184
THR X 188
 None
 0.98A 4ma7A-2p4hX:
undetectable		 4ma7A-2p4hX:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 2p4h VESTITONE REDUCTASE
(Medicago
sativa) 		5 / 9 GLY X  81
ASP X 185
VAL X 187
ILE X 239
THR X 127
 None
 1.13A 4njtD-2p4hX:
undetectable		 4njtD-2p4hX:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2p4h VESTITONE REDUCTASE
(Medicago
sativa) 		5 / 12 ILE X  21
ILE X  22
LEU X  25
THR X  35
VAL X  32
 None
 0.83A 4nkvB-2p4hX:
undetectable		 4nkvB-2p4hX:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 2p4h VESTITONE REDUCTASE
(Medicago
sativa) 		3 / 3 ARG X 197
GLN X 318
GLU X 322
 None
 0.93A 4tvtA-2p4hX:
undetectable		 4tvtA-2p4hX:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2p4h VESTITONE REDUCTASE
(Medicago
sativa) 		3 / 3 VAL X 258
HIS X 230
VAL X 195
 None
 0.52A 5jmnC-2p4hX:
undetectable		 5jmnC-2p4hX:
16.60