SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		5 / 12 THR A 228
GLY A 226
VAL A 273
ALA A 247
ILE A 246
 None
 0.93A 1bx4A-2p4oA:
undetectable		 1bx4A-2p4oA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		5 / 9 GLY A 255
GLY A 226
ALA A 247
HIS A 229
THR A 228
 None
None
None
ACT  A 306 ( 4.6A)
None
 1.15A 1gtfD-2p4oA:
undetectable
1gtfE-2p4oA:
undetectable		 1gtfD-2p4oA:
14.90
1gtfE-2p4oA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		5 / 9 GLY A 226
ALA A 247
HIS A 229
THR A 228
GLY A 255
 None
None
ACT  A 306 ( 4.6A)
None
None
 1.22A 1gtfR-2p4oA:
undetectable
1gtfS-2p4oA:
undetectable		 1gtfR-2p4oA:
14.90
1gtfS-2p4oA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		4 / 6 PHE A 261
GLU A 296
LEU A 295
VAL A 234
 None
 0.91A 1hk1A-2p4oA:
undetectable		 1hk1A-2p4oA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		4 / 7 PHE A 261
GLU A 296
LEU A 295
VAL A 234
 None
 0.90A 1hk2A-2p4oA:
undetectable		 1hk2A-2p4oA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		5 / 10 THR A 228
GLY A 226
VAL A 273
ALA A 247
ILE A 246
 None
 0.97A 1likA-2p4oA:
undetectable		 1likA-2p4oA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		6 / 12 LEU A 295
ALA A 227
ASP A 214
ASP A 215
ILE A 254
VAL A 293
 None
None
ACT  A 306 (-2.7A)
None
None
None
 1.48A 2ieoA-2p4oA:
undetectable		 2ieoA-2p4oA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		5 / 12 ALA A 258
ASP A 214
GLY A 120
ILE A 121
ALA A  37
 None
ACT  A 306 (-2.7A)
None
None
None
 1.10A 3n3iA-2p4oA:
undetectable		 3n3iA-2p4oA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		5 / 11 ALA A 115
ARG A 160
ASP A 133
GLY A 137
ALA A 138
 None
 1.18A 3rukD-2p4oA:
undetectable		 3rukD-2p4oA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		4 / 5 PHE A 176
TYR A 225
ILE A 206
LEU A 191
 None
 1.34A 3sueC-2p4oA:
undetectable		 3sueC-2p4oA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		3 / 3 LEU A 158
HIS A 155
MET A 157
 None
 0.90A 3thrD-2p4oA:
undetectable		 3thrD-2p4oA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		4 / 6 ILE A 213
LEU A 190
TYR A  11
THR A 244
 None
 1.01A 3wg7A-2p4oA:
undetectable
3wg7J-2p4oA:
undetectable		 3wg7A-2p4oA:
20.92
3wg7J-2p4oA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		4 / 8 LEU A 112
ASN A 119
GLY A 120
ILE A 121
 None
ACT  A 306 (-3.2A)
None
None
 0.69A 3wxoA-2p4oA:
undetectable		 3wxoA-2p4oA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		3 / 3 ASN A 162
GLU A 186
ARG A 160
 None
 1.10A 3wxoA-2p4oA:
undetectable		 3wxoA-2p4oA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		5 / 12 VAL A  51
GLY A  52
VAL A  73
PHE A  32
PRO A  28
 None
None
None
ACT  A 306 (-4.8A)
None
 1.22A 4bvaB-2p4oA:
undetectable		 4bvaB-2p4oA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		4 / 5 THR A 275
GLY A 277
VAL A 287
PRO A 289
 None
 1.18A 4grkA-2p4oA:
undetectable		 4grkA-2p4oA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		5 / 12 ARG A 192
GLY A 177
ALA A 238
PHE A 176
TYR A 181
 None
 1.17A 4r29A-2p4oA:
undetectable		 4r29A-2p4oA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		5 / 12 ARG A 192
GLY A 177
ALA A 238
PHE A 176
TYR A 181
 None
 1.20A 4r29B-2p4oA:
undetectable		 4r29B-2p4oA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		4 / 6 ILE A 213
LEU A 190
TYR A  11
THR A 244
 None
 1.05A 5b1aN-2p4oA:
undetectable
5b1aW-2p4oA:
undetectable		 5b1aN-2p4oA:
20.92
5b1aW-2p4oA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		5 / 12 GLY A 120
GLY A  75
GLY A  88
LEU A 118
LEU A 173
 None
 1.14A 5c0oE-2p4oA:
undetectable		 5c0oE-2p4oA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		5 / 12 LEU A  76
ILE A 271
LEU A 295
GLY A 226
GLY A 120
 None
 0.97A 5d4uC-2p4oA:
undetectable		 5d4uC-2p4oA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		5 / 12 LEU A  76
ILE A 271
LEU A 295
GLY A 226
GLY A 120
 None
 1.02A 5d4uD-2p4oA:
undetectable		 5d4uD-2p4oA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		3 / 3 LYS A 200
ASP A 196
ARG A 175
 None
 1.06A 5jwaA-2p4oA:
undetectable
5jwaH-2p4oA:
undetectable		 5jwaA-2p4oA:
19.92
5jwaH-2p4oA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		3 / 3 VAL A 274
VAL A 292
GLN A  63
 None
 0.61A 5qglA-2p4oA:
undetectable		 5qglA-2p4oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		3 / 3 VAL A 274
VAL A 292
GLN A  63
 None
 0.70A 5qgvA-2p4oA:
undetectable		 5qgvA-2p4oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGX_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		3 / 3 VAL A 274
VAL A 292
GLN A  63
 None
 0.71A 5qgxA-2p4oA:
undetectable		 5qgxA-2p4oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH1_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		3 / 3 VAL A 274
VAL A 292
GLN A  63
 None
 0.69A 5qh1A-2p4oA:
undetectable		 5qh1A-2p4oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH4_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		3 / 3 VAL A 274
VAL A 292
GLN A  63
 None
 0.71A 5qh4A-2p4oA:
undetectable		 5qh4A-2p4oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHC_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		3 / 3 VAL A 274
VAL A 292
GLN A  63
 None
 0.69A 5qhcA-2p4oA:
undetectable		 5qhcA-2p4oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHE_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		3 / 3 VAL A 274
VAL A 292
GLN A  63
 None
 0.72A 5qheA-2p4oA:
undetectable		 5qheA-2p4oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		3 / 3 VAL A 274
VAL A 292
GLN A  63
 None
 0.69A 5qhgA-2p4oA:
undetectable		 5qhgA-2p4oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		5 / 12 GLU A  34
ASN A  35
GLY A  75
VAL A 234
ASN A 171
 ACT  A 306 (-2.7A)
None
None
None
ACT  A 306 (-3.3A)
 1.18A 5vopB-2p4oA:
undetectable		 5vopB-2p4oA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		5 / 8 SER A 134
GLY A 172
ALA A 170
GLY A 120
SER A  74
 None
 1.32A 5vw9A-2p4oA:
undetectable		 5vw9A-2p4oA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		4 / 7 ILE A 213
LEU A 190
TYR A  11
THR A 244
 None
 0.98A 5xdxA-2p4oA:
undetectable
5xdxJ-2p4oA:
undetectable		 5xdxA-2p4oA:
20.92
5xdxJ-2p4oA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		4 / 7 ILE A 213
LEU A 190
TYR A  11
THR A 244
 None
 0.97A 6nmfA-2p4oA:
undetectable
6nmfJ-2p4oA:
undetectable		 6nmfA-2p4oA:
20.92
6nmfJ-2p4oA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		4 / 6 ILE A 213
LEU A 190
TYR A  11
THR A 244
 None
 0.96A 6nmfN-2p4oA:
undetectable
6nmfW-2p4oA:
undetectable		 6nmfN-2p4oA:
20.92
6nmfW-2p4oA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2p4o HYPOTHETICAL PROTEIN
(Nostoc
punctiforme) 		4 / 7 ILE A 213
LEU A 190
TYR A  11
THR A 244
 None
 0.94A 6nmpA-2p4oA:
undetectable
6nmpJ-2p4oA:
undetectable		 6nmpA-2p4oA:
20.92
6nmpJ-2p4oA:
12.82