SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CSW_A_P06A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2p4p	HYPOTHETICAL PROTEIN HD1797 ([Haemophilus] ducreyi)	3 / 3	PHE A 62 ILE A 37 ASP A 73	MLY A 61 ( 4.5A) None None	0.74A	5cswA-2p4pA: undetectable	5cswA-2p4pA: 14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CSW_B_P06B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2p4p	HYPOTHETICAL PROTEIN HD1797 ([Haemophilus] ducreyi)	3 / 3	PHE A 62 ILE A 37 ASP A 73	MLY A 61 ( 4.5A) None None	0.69A	5cswB-2p4pA: undetectable	5cswB-2p4pA: 14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2p4p	HYPOTHETICAL PROTEIN HD1797 ([Haemophilus] ducreyi)	4 / 6	PHE A 28 PHE A 54 VAL A 19 ASP A 58	None MLY A 61 ( 3.7A) CA A 201 ( 4.2A) MLY A 59 ( 3.2A)	1.17A	5hesA-2p4pA: undetectable	5hesA-2p4pA: 12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HUA_A_FK5A201_1 (FK506-BINDING PROTEIN 1)	2p4p	HYPOTHETICAL PROTEIN HD1797 ([Haemophilus] ducreyi)	5 / 11	TYR A 60 ASP A 58 ILE A 37 PHE A 28 PHE A 62	MLY A 59 ( 3.8A) MLY A 59 ( 3.2A) None None MLY A 61 ( 4.5A)	1.13A	5huaA-2p4pA: undetectable	5huaA-2p4pA: 23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HWC_A_FK5A201_1 (FK506-BINDING PROTEIN 1A)	2p4p	HYPOTHETICAL PROTEIN HD1797 ([Haemophilus] ducreyi)	5 / 11	TYR A 60 ASP A 58 ILE A 37 PHE A 28 PHE A 62	MLY A 59 ( 3.8A) MLY A 59 ( 3.2A) None None MLY A 61 ( 4.5A)	1.11A	5hwcA-2p4pA: undetectable	5hwcA-2p4pA: 17.39

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["5CSW_A_P06A801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","2p4p","HYPOTHETICAL PROTEIN HD1797","[Haemophilus] ducreyi",3,"PHE A  62;ILE A  37;ASP A  73","MLY A  61 ( 4.5A);None;None","0.74A","5cswA-2p4pA:undetectable","5cswA-2p4pA:14.60"],["5CSW_B_P06B801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","2p4p","HYPOTHETICAL PROTEIN HD1797","[Haemophilus] ducreyi",3,"PHE A  62;ILE A  37;ASP A  73","MLY A  61 ( 4.5A);None;None","0.69A","5cswB-2p4pA:undetectable","5cswB-2p4pA:14.60"],["5HES_A_032A401_2","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","2p4p","HYPOTHETICAL PROTEIN HD1797","[Haemophilus] ducreyi",4,"PHE A  28;PHE A  54;VAL A  19;ASP A  58","None;MLY A  61 ( 3.7A); CA A 201 ( 4.2A);MLY A  59 ( 3.2A)","1.17A","5hesA-2p4pA:undetectable","5hesA-2p4pA:12.46"],["5HUA_A_FK5A201_1","FK506-BINDING PROTEIN 1","2p4p","HYPOTHETICAL PROTEIN HD1797","[Haemophilus] ducreyi",5,"TYR A  60;ASP A  58;ILE A  37;PHE A  28;PHE A  62","MLY A  59 ( 3.8A);MLY A  59 ( 3.2A);None;None;MLY A  61 ( 4.5A)","1.13A","5huaA-2p4pA:undetectable","5huaA-2p4pA:23.20"],["5HWC_A_FK5A201_1","FK506-BINDING PROTEIN 1A","2p4p","HYPOTHETICAL PROTEIN HD1797","[Haemophilus] ducreyi",5,"TYR A  60;ASP A  58;ILE A  37;PHE A  28;PHE A  62","MLY A  59 ( 3.8A);MLY A  59 ( 3.2A);None;None;MLY A  61 ( 4.5A)","1.11A","5hwcA-2p4pA:undetectable","5hwcA-2p4pA:17.39"]]