SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p4q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 11 GLU A  45
LEU A  19
LEU A  10
ALA A  30
GLY A  53
 None
 1.26A 1cmaA-2p4qA:
undetectable
1cmaB-2p4qA:
undetectable		 1cmaA-2p4qA:
12.11
1cmaB-2p4qA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  30
GLY A  53
GLU A  45
LEU A  19
LEU A  10
 None
 1.19A 1cmcA-2p4qA:
undetectable
1cmcB-2p4qA:
undetectable		 1cmcA-2p4qA:
12.11
1cmcB-2p4qA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 10 GLU A  45
LEU A  19
LEU A  10
ALA A  30
GLY A  53
 None
 1.24A 1cmcA-2p4qA:
undetectable
1cmcB-2p4qA:
undetectable		 1cmcA-2p4qA:
12.11
1cmcB-2p4qA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 11 CYH A 365
SER A 139
HIS A 185
LEU A 352
ILE A 357
 None
None
FLC  A 502 (-4.5A)
None
None
 1.19A 1ee2B-2p4qA:
2.7		 1ee2B-2p4qA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  30
GLY A  53
GLU A  45
LEU A  19
LEU A  10
 None
 1.25A 1mj2A-2p4qA:
undetectable
1mj2B-2p4qA:
undetectable		 1mj2A-2p4qA:
12.32
1mj2B-2p4qA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  30
GLY A  53
GLU A  45
LEU A  19
LEU A  10
 None
 1.21A 1mj2C-2p4qA:
undetectable
1mj2D-2p4qA:
undetectable		 1mj2C-2p4qA:
12.32
1mj2D-2p4qA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  30
GLY A  53
GLU A  45
LEU A  19
LEU A  10
 None
 1.25A 1mjoC-2p4qA:
undetectable
1mjoD-2p4qA:
undetectable		 1mjoC-2p4qA:
12.32
1mjoD-2p4qA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 11 GLU A  45
LEU A  19
LEU A  10
ALA A  30
GLY A  53
 None
 1.18A 1mjqA-2p4qA:
undetectable
1mjqB-2p4qA:
undetectable		 1mjqA-2p4qA:
12.32
1mjqB-2p4qA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 10 GLU A  45
LEU A  19
LEU A  10
ALA A  30
GLY A  53
 None
 1.21A 1mjqC-2p4qA:
undetectable
1mjqD-2p4qA:
undetectable		 1mjqC-2p4qA:
12.32
1mjqD-2p4qA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  30
GLY A  53
GLU A  45
LEU A  19
LEU A  10
 None
 1.14A 1mjqC-2p4qA:
undetectable
1mjqD-2p4qA:
undetectable		 1mjqC-2p4qA:
12.32
1mjqD-2p4qA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 11 GLU A  45
LEU A  19
LEU A  10
ALA A  30
GLY A  53
 None
 1.23A 1mjqI-2p4qA:
undetectable
1mjqJ-2p4qA:
undetectable		 1mjqI-2p4qA:
12.32
1mjqJ-2p4qA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  30
GLY A  53
GLU A  45
LEU A  19
LEU A  10
 None
 1.13A 1mjqI-2p4qA:
undetectable
1mjqJ-2p4qA:
undetectable		 1mjqI-2p4qA:
12.32
1mjqJ-2p4qA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  72
ARG A  68
ILE A  61
PHE A  60
ILE A   8
 None
 1.47A 1ot7B-2p4qA:
undetectable		 1ot7B-2p4qA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  19
GLY A  53
ALA A  22
ILE A  18
 None
 0.70A 2aohB-2p4qA:
undetectable		 2aohB-2p4qA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 124
SER A 125
LEU A 140
LEU A  17
ASP A  99
 None
 1.19A 2j2pB-2p4qA:
undetectable
2j2pC-2p4qA:
undetectable		 2j2pB-2p4qA:
18.22
2j2pC-2p4qA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		3 / 3 HIS A  24
ILE A 155
LEU A  17
 None
 0.74A 2kceA-2p4qA:
undetectable		 2kceA-2p4qA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 195
ALA A 199
TRP A 221
LEU A 322
 None
 1.23A 2oaxA-2p4qA:
undetectable		 2oaxA-2p4qA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 121
GLY A 144
ILE A  98
ILE A  96
 None
 0.86A 2q9rA-2p4qA:
undetectable		 2q9rA-2p4qA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 372
SER A 128
VAL A 184
GLY A 187
 None
FLC  A 502 (-2.4A)
None
None
 1.01A 2qd5A-2p4qA:
3.0		 2qd5A-2p4qA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		4 / 6 ILE A  97
ARG A 111
LEU A 115
LEU A  72
 None
 0.83A 2rlfA-2p4qA:
undetectable
2rlfD-2p4qA:
undetectable		 2rlfA-2p4qA:
6.95
2rlfD-2p4qA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 172
GLY A 143
SER A 108
PHE A 105
PRO A 106
 None
 1.04A 3bjwF-2p4qA:
1.0		 3bjwF-2p4qA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		4 / 4 GLY A 176
GLY A 143
GLY A 173
GLY A 178
 None
 0.65A 3bogD-2p4qA:
undetectable		 3bogD-2p4qA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 11 ALA A  54
LEU A  42
VAL A  38
ILE A  18
THR A  55
 None
 1.13A 3fl9C-2p4qA:
undetectable		 3fl9C-2p4qA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 9 ALA A  54
LEU A  42
VAL A  38
ILE A  18
THR A  55
 None
 1.17A 3fl9H-2p4qA:
undetectable		 3fl9H-2p4qA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 143
GLY A 144
VAL A 123
CYH A 169
ILE A 152
 None
 1.27A 3h52B-2p4qA:
undetectable		 3h52B-2p4qA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 192
PHE A 371
SER A 329
 None
 1.00A 3i5uB-2p4qA:
6.5		 3i5uB-2p4qA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 177
LEU A 352
ILE A 357
ALA A 358
THR A 376
 None
 1.26A 3r9cA-2p4qA:
undetectable		 3r9cA-2p4qA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		4 / 7 PRO A 174
GLY A 176
ALA A 177
ALA A 344
 None
 0.56A 3ur0B-2p4qA:
undetectable		 3ur0B-2p4qA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 262
THR A 265
ASN A 186
 None
None
FLC  A 502 (-2.6A)
 0.68A 3v4tD-2p4qA:
1.3		 3v4tD-2p4qA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 124
GLY A 100
LEU A  73
ALA A 177
PHE A 156
 None
 1.18A 3vywA-2p4qA:
3.3		 3vywA-2p4qA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 124
GLY A 100
LEU A  73
ALA A 177
PHE A 156
 None
 1.20A 3vywB-2p4qA:
3.4		 3vywB-2p4qA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 124
GLY A 100
LEU A  73
ALA A 177
PHE A 156
 None
 1.23A 3vywD-2p4qA:
3.4		 3vywD-2p4qA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 297
VAL A 301
LEU A 302
SER A 299
 None
 1.22A 4e1gA-2p4qA:
undetectable		 4e1gA-2p4qA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 156
GLY A 144
GLY A 173
ALA A 148
ILE A  98
 None
 1.10A 4krhB-2p4qA:
3.6		 4krhB-2p4qA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 269
ILE A 279
GLN A 336
ILE A 341
TYR A 180
 None
 0.91A 4m2xG-2p4qA:
2.4		 4m2xG-2p4qA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 341
ILE A 188
SER A 333
LEU A 388
 None
 0.97A 4m51A-2p4qA:
undetectable		 4m51A-2p4qA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 187
GLY A 191
THR A 265
ASN A 186
ILE A 267
 None
None
None
FLC  A 502 (-2.6A)
None
 0.97A 4n49A-2p4qA:
3.1		 4n49A-2p4qA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 367
ASP A 192
GLY A 337
VAL A 276
 None
 0.93A 4oltA-2p4qA:
undetectable		 4oltA-2p4qA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 367
ASP A 192
GLY A 337
VAL A 276
 None
 0.96A 4oltB-2p4qA:
undetectable		 4oltB-2p4qA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		6 / 12 GLY A  14
GLU A 131
ASN A  16
ILE A  18
ALA A  30
VAL A  28
 None
 1.48A 4u95B-2p4qA:
2.3		 4u95B-2p4qA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		4 / 8 SER A 103
ALA A  76
HIS A 179
LEU A  73
 None
 0.94A 5dzkd-2p4qA:
undetectable
5dzkr-2p4qA:
undetectable		 5dzkd-2p4qA:
17.73
5dzkr-2p4qA:
2.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		4 / 8 SER A 103
ALA A  76
HIS A 179
LEU A  73
 None
 0.94A 5dzkF-2p4qA:
undetectable
5dzkT-2p4qA:
undetectable		 5dzkF-2p4qA:
17.73
5dzkT-2p4qA:
2.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 129
PHE A 394
TYR A 379
PHE A 371
HIS A 185
 FLC  A 502 ( 4.5A)
None
None
None
FLC  A 502 (-4.5A)
 1.11A 5fsaB-2p4qA:
undetectable		 5fsaB-2p4qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		3 / 3 HIS A  24
SER A 160
LYS A 162
 None
 1.28A 5os7A-2p4qA:
undetectable		 5os7A-2p4qA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 7 GLY A 101
GLY A 100
GLY A 124
GLY A 176
GLY A 178
 None
 1.04A 6ag0A-2p4qA:
undetectable		 6ag0A-2p4qA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 10 ASN A 387
ARG A 342
ALA A 335
GLY A 337
ILE A 357
 None
 1.19A 6bniA-2p4qA:
undetectable		 6bniA-2p4qA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  73
GLY A 100
ILE A  97
VAL A  80
LEU A  83
 None
 0.86A 6ectA-2p4qA:
4.3		 6ectA-2p4qA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  73
GLY A 100
ILE A  97
VAL A  80
LEU A  83
 None
 0.94A 6ecxA-2p4qA:
4.2		 6ecxA-2p4qA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1
(Saccharomyces
cerevisiae) 		3 / 3 HIS A  24
SER A 160
LYS A 162
 None
 1.28A 6gmdB-2p4qA:
undetectable		 6gmdB-2p4qA:
21.74