SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE
(Anopheles
gambiae) 		5 / 10 THR A 199
GLY A 117
CYH A 116
THR A 122
GLY A 349
 None
PO4  A 503 (-3.4A)
None
None
None
 1.12A 1h4oA-2p4sA:
undetectable
1h4oB-2p4sA:
undetectable		 1h4oA-2p4sA:
18.36
1h4oB-2p4sA:
18.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE
(Anopheles
gambiae) 		8 / 10 GLY A 203
PHE A 285
GLU A 286
GLY A 303
MET A 304
THR A 327
ASN A 328
HIS A 342
 DIH  A 401 (-3.4A)
DIH  A 401 (-4.6A)
DIH  A 401 (-2.8A)
DIH  A 401 (-3.4A)
DIH  A 401 (-3.5A)
DIH  A 401 (-4.2A)
DIH  A 401 (-3.1A)
DIH  A 401 (-3.6A)
 0.71A 1pwyE-2p4sA:
40.6		 1pwyE-2p4sA:
42.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE
(Anopheles
gambiae) 		4 / 6 ASP A 213
TYR A 209
ASP A 300
GLU A 269
 None
 1.20A 1rjdA-2p4sA:
undetectable		 1rjdA-2p4sA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE
(Anopheles
gambiae) 		4 / 6 ASP A 213
TYR A 209
ASP A 300
GLU A 269
 None
 1.19A 1rjdB-2p4sA:
undetectable		 1rjdB-2p4sA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE
(Anopheles
gambiae) 		4 / 6 ASP A 213
TYR A 209
ASP A 300
GLU A 269
 None
 1.18A 1rjdC-2p4sA:
undetectable		 1rjdC-2p4sA:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE
(Anopheles
gambiae) 		8 / 10 GLY A 203
PHE A 285
GLU A 286
GLY A 303
MET A 304
THR A 327
ASN A 328
HIS A 342
 DIH  A 401 (-3.4A)
DIH  A 401 (-4.6A)
DIH  A 401 (-2.8A)
DIH  A 401 (-3.4A)
DIH  A 401 (-3.5A)
DIH  A 401 (-4.2A)
DIH  A 401 (-3.1A)
DIH  A 401 (-3.6A)
 0.49A 1v3qE-2p4sA:
41.1		 1v3qE-2p4sA:
42.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE
(Anopheles
gambiae) 		4 / 6 ASP A  93
LEU A 190
ASP A 237
HIS A 315
 None
 1.19A 3bj8C-2p4sA:
undetectable
3bj8D-2p4sA:
undetectable		 3bj8C-2p4sA:
17.65
3bj8D-2p4sA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE
(Anopheles
gambiae) 		5 / 12 GLY A 168
ILE A 197
LEU A 196
MET A 188
LEU A 123
 None
 1.19A 3cs8A-2p4sA:
undetectable		 3cs8A-2p4sA:
20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE
(Anopheles
gambiae) 		5 / 6 GLY A 203
GLU A 286
GLY A 303
MET A 304
ASN A 328
 DIH  A 401 (-3.4A)
DIH  A 401 (-2.8A)
DIH  A 401 (-3.4A)
DIH  A 401 (-3.5A)
DIH  A 401 (-3.1A)
 0.53A 3e9rA-2p4sA:
39.9		 3e9rA-2p4sA:
35.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE
(Anopheles
gambiae) 		5 / 6 GLY A 203
GLU A 286
GLY A 303
MET A 304
ASN A 328
 DIH  A 401 (-3.4A)
DIH  A 401 (-2.8A)
DIH  A 401 (-3.4A)
DIH  A 401 (-3.5A)
DIH  A 401 (-3.1A)
 0.58A 3e9rC-2p4sA:
40.3		 3e9rC-2p4sA:
35.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE
(Anopheles
gambiae) 		9 / 12 SER A 118
TYR A 173
ALA A 201
GLY A 203
GLU A 286
GLY A 303
MET A 304
ASN A 328
HIS A 342
 PO4  A 503 (-2.8A)
DIH  A 401 (-4.7A)
PO4  A 503 ( 3.8A)
DIH  A 401 (-3.4A)
DIH  A 401 (-2.8A)
DIH  A 401 (-3.4A)
DIH  A 401 (-3.5A)
DIH  A 401 (-3.1A)
DIH  A 401 (-3.6A)
 0.39A 3f8wA-2p4sA:
41.5		 3f8wA-2p4sA:
35.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE
(Anopheles
gambiae) 		9 / 12 SER A 118
HIS A 171
TYR A 173
GLY A 203
GLU A 286
GLY A 303
MET A 304
ASN A 328
HIS A 342
 PO4  A 503 (-2.8A)
DIH  A 401 ( 4.0A)
DIH  A 401 (-4.7A)
DIH  A 401 (-3.4A)
DIH  A 401 (-2.8A)
DIH  A 401 (-3.4A)
DIH  A 401 (-3.5A)
DIH  A 401 (-3.1A)
DIH  A 401 (-3.6A)
 0.43A 3f8wB-2p4sA:
43.3		 3f8wB-2p4sA:
35.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE
(Anopheles
gambiae) 		9 / 12 SER A 118
HIS A 171
TYR A 173
ALA A 201
GLY A 203
GLU A 286
GLY A 303
MET A 304
ASN A 328
 PO4  A 503 (-2.8A)
DIH  A 401 ( 4.0A)
DIH  A 401 (-4.7A)
PO4  A 503 ( 3.8A)
DIH  A 401 (-3.4A)
DIH  A 401 (-2.8A)
DIH  A 401 (-3.4A)
DIH  A 401 (-3.5A)
DIH  A 401 (-3.1A)
 0.36A 3f8wC-2p4sA:
41.3		 3f8wC-2p4sA:
35.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE
(Anopheles
gambiae) 		5 / 12 ILE A 138
PHE A 170
THR A 145
THR A 312
ALA A 179
 None
 1.30A 3ua1A-2p4sA:
undetectable		 3ua1A-2p4sA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE
(Anopheles
gambiae) 		5 / 12 ALA A 198
ARG A 169
GLY A 117
ALA A 301
GLY A 303
 None
PO4  A 503 (-3.9A)
PO4  A 503 (-3.4A)
None
DIH  A 401 (-3.4A)
 1.27A 4r29C-2p4sA:
undetectable		 4r29C-2p4sA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE
(Anopheles
gambiae) 		4 / 5 ILE A 367
VAL A 112
ILE A 114
VAL A 364
 None
 0.72A 4xdtA-2p4sA:
undetectable		 4xdtA-2p4sA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE
(Anopheles
gambiae) 		3 / 3 GLU A  97
TYR A 101
ARG A 105
 None
 0.83A 5uunB-2p4sA:
undetectable		 5uunB-2p4sA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE
(Anopheles
gambiae) 		5 / 12 GLU A 174
PRO A 283
GLU A 286
THR A 327
GLY A 203
 None
None
DIH  A 401 (-2.8A)
DIH  A 401 (-4.2A)
DIH  A 401 (-3.4A)
 1.20A 5xioA-2p4sA:
2.4		 5xioA-2p4sA:
21.65