SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p4v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SQF_A_SAMA430_1 (SUN PROTEIN)	2p4v	TRANSCRIPTION ELONGATION FACTOR GREB (Escherichia coli)	3 / 3	PRO A 4 ASP A 109 ASP A 121	None	0.76A	1sqfA-2p4vA: undetectable	1sqfA-2p4vA: 15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AZX_A_TRPA601_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	2p4v	TRANSCRIPTION ELONGATION FACTOR GREB (Escherichia coli)	5 / 12	GLY A 107 GLY A 10 THR A 7 GLU A 9 ILE A 118	None	1.33A	2azxA-2p4vA: undetectable	2azxA-2p4vA: 15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FUM_D_MIXD3539_2 (PROBABLE SERINE/THREONINE-PRO TEIN KINASE PKNB)	2p4v	TRANSCRIPTION ELONGATION FACTOR GREB (Escherichia coli)	3 / 3	VAL A 91 VAL A 133 ASP A 96	None	0.71A	2fumD-2p4vA: undetectable	2fumD-2p4vA: 21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NM5_B_LOCB502_1 (TUBULIN ALPHA-1B CHAIN TUBULIN BETA-2B CHAIN)	2p4v	TRANSCRIPTION ELONGATION FACTOR GREB (Escherichia coli)	4 / 4	ASN A 45 SER A 38 ALA A 36 VAL A 33	None	1.36A	5nm5A-2p4vA: undetectable	5nm5A-2p4vA: 15.77

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1SQF_A_SAMA430_1","SUN PROTEIN","2p4v","TRANSCRIPTION ELONGATION FACTOR GREB","Escherichia coli",3,"PRO A   4;ASP A 109;ASP A 121","None","0.76A","1sqfA-2p4vA:undetectable","1sqfA-2p4vA:15.85"],["2AZX_A_TRPA601_0","TRYPTOPHANYL-TRNA SYNTHETASE","2p4v","TRANSCRIPTION ELONGATION FACTOR GREB","Escherichia coli",5,"GLY A 107;GLY A  10;THR A   7;GLU A   9;ILE A 118","None","1.33A","2azxA-2p4vA:undetectable","2azxA-2p4vA:15.61"],["2FUM_D_MIXD3539_2","PROBABLE SERINE\/THREONINE-PROTEIN KINASE PKNB","2p4v","TRANSCRIPTION ELONGATION FACTOR GREB","Escherichia coli",3,"VAL A  91;VAL A 133;ASP A  96","None","0.71A","2fumD-2p4vA:undetectable","2fumD-2p4vA:21.89"],["5NM5_B_LOCB502_1","TUBULIN ALPHA-1B CHAIN;TUBULIN BETA-2B CHAIN","2p4v","TRANSCRIPTION ELONGATION FACTOR GREB","Escherichia coli",4,"ASN A  45;SER A  38;ALA A  36;VAL A  33","None","1.36A","5nm5A-2p4vA:undetectable","5nm5A-2p4vA:15.77"]]