SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p4z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 10 GLY A 197
LEU A  36
PHE A 226
THR A 253
LEU A 276
 None
 1.44A 1a8uA-2p4zA:
2.1		 1a8uA-2p4zA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		4 / 5 THR A 161
GLU A 181
THR A  75
HIS A  81
 None
None
None
FE  A1002 (-3.4A)
 1.40A 1d4fA-2p4zA:
undetectable		 1d4fA-2p4zA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		4 / 5 ASP A  80
HIS A  81
HIS A  32
HIS A 255
 FE  A1002 (-2.5A)
FE  A1002 (-3.4A)
None
FE  A1002 (-3.5A)
 1.06A 1ei6A-2p4zA:
undetectable		 1ei6A-2p4zA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		4 / 8 ILE A  97
PHE A 125
LEU A  88
VAL A  72
 None
 0.88A 1fslA-2p4zA:
undetectable		 1fslA-2p4zA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 GLY A 225
GLY A 224
VAL A  15
LEU A  36
LEU A 222
 None
 0.89A 1mx1F-2p4zA:
undetectable		 1mx1F-2p4zA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 THR A 152
LEU A 222
VAL A 248
VAL A 194
THR A 196
 None
 1.23A 1q23B-2p4zA:
undetectable		 1q23B-2p4zA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		3 / 3 LYS A  96
ILE A  45
THR A  49
 None
 0.83A 1rx3A-2p4zA:
undetectable		 1rx3A-2p4zA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		4 / 4 LEU A 252
SER A 274
TYR A 275
LEU A 276
 None
 1.22A 1xz1A-2p4zA:
undetectable		 1xz1A-2p4zA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		4 / 4 LEU A 252
SER A 274
TYR A 275
LEU A 276
 None
 1.22A 1xz3A-2p4zA:
undetectable		 1xz3A-2p4zA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  38
GLY A 145
ILE A 149
VAL A  47
ILE A  45
 None
 0.88A 2f80B-2p4zA:
undetectable		 2f80B-2p4zA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 ASP A  48
ILE A  82
GLY A  83
GLY A  84
ILE A  97
 None
 1.09A 2o4kA-2p4zA:
undetectable		 2o4kA-2p4zA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  38
GLY A 145
ILE A 149
VAL A  47
ILE A  45
 None
 0.93A 2pymA-2p4zA:
undetectable		 2pymA-2p4zA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  38
GLY A 145
ILE A 149
VAL A  47
ILE A  45
 None
 0.92A 2pymB-2p4zA:
undetectable		 2pymB-2p4zA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 11 ASP A  80
HIS A  81
HIS A 200
PHE A 165
HIS A 255
 FE  A1002 (-2.5A)
FE  A1002 (-3.4A)
FE  A1001 (-3.3A)
None
FE  A1002 (-3.5A)
 0.69A 2q0jB-2p4zA:
9.7		 2q0jB-2p4zA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A 204
VAL A 236
ARG A 241
LEU A 228
THR A 161
 None
 1.41A 2q7kA-2p4zA:
undetectable		 2q7kA-2p4zA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 ILE A  69
ILE A  82
THR A  49
LEU A  85
THR A  99
 None
 1.17A 2qo5A-2p4zA:
undetectable		 2qo5A-2p4zA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 THR A 161
ILE A 239
LEU A 228
VAL A 248
LEU A 222
 None
 1.20A 3a51C-2p4zA:
undetectable		 3a51C-2p4zA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  38
GLY A 145
ILE A 149
VAL A  47
ILE A  45
 None
 0.87A 3bvbA-2p4zA:
undetectable		 3bvbA-2p4zA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  38
GLY A 145
ILE A 149
VAL A  47
ILE A  45
 None
 0.75A 3cywA-2p4zA:
undetectable		 3cywA-2p4zA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  38
GLY A 145
ILE A 149
VAL A  47
ILE A  45
 None
 0.93A 3cywB-2p4zA:
undetectable		 3cywB-2p4zA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		6 / 12 ALA A 140
ASP A 139
ILE A 149
VAL A 185
ILE A  45
ILE A 136
 None
 1.36A 3ekqA-2p4zA:
undetectable		 3ekqA-2p4zA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 10 ASP A  48
ILE A  82
GLY A  83
GLY A  84
ILE A  97
 None
 1.07A 3em4V-2p4zA:
undetectable		 3em4V-2p4zA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 9 LEU A 207
VAL A 251
ILE A 239
LEU A 265
PHE A 226
 None
 1.31A 3fl9D-2p4zA:
undetectable		 3fl9D-2p4zA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		4 / 5 THR A 161
GLU A 181
THR A  75
HIS A  81
 None
None
None
FE  A1002 (-3.4A)
 1.29A 3glqA-2p4zA:
3.1		 3glqA-2p4zA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		4 / 5 THR A 161
GLU A 181
THR A  75
HIS A  81
 None
None
None
FE  A1002 (-3.4A)
 1.32A 3glqB-2p4zA:
undetectable		 3glqB-2p4zA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 PHE A 183
GLY A 202
PHE A 226
ILE A 239
LEU A 204
 None
 1.26A 3iv6B-2p4zA:
undetectable		 3iv6B-2p4zA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  38
GLY A 145
ILE A 149
VAL A  47
ILE A  45
 None
 0.93A 3jvyB-2p4zA:
undetectable		 3jvyB-2p4zA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  38
GLY A 145
ILE A 149
VAL A  47
ILE A  45
 None
 0.86A 3jw2A-2p4zA:
undetectable		 3jw2A-2p4zA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  38
GLY A 145
ILE A 149
VAL A  47
ILE A  45
 None
 0.96A 3k4vD-2p4zA:
undetectable		 3k4vD-2p4zA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  38
GLY A 145
ILE A 149
VAL A  47
ILE A  45
 None
 0.89A 3lzsA-2p4zA:
undetectable		 3lzsA-2p4zA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  38
GLY A 145
ILE A 149
VAL A  47
ILE A  45
 None
 0.94A 3lzsB-2p4zA:
undetectable		 3lzsB-2p4zA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  38
GLY A 145
ILE A 149
VAL A  47
ILE A  45
 None
 0.92A 3lzuA-2p4zA:
undetectable		 3lzuA-2p4zA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		4 / 5 THR A 161
GLU A 181
THR A  75
HIS A  81
 None
None
None
FE  A1002 (-3.4A)
 1.34A 3n58A-2p4zA:
undetectable		 3n58A-2p4zA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  38
GLY A 145
ILE A 149
VAL A  47
ILE A  45
 None
 0.85A 3ndtB-2p4zA:
undetectable		 3ndtB-2p4zA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  38
GLY A 145
ILE A 149
VAL A  47
ILE A  45
 None
 0.94A 3ndtD-2p4zA:
undetectable		 3ndtD-2p4zA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  38
GLY A 145
ILE A 149
VAL A  47
ILE A  45
 None
 0.88A 3nduB-2p4zA:
undetectable		 3nduB-2p4zA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  38
GLY A 145
ILE A 149
VAL A  47
ILE A  45
 None
 0.98A 3tkgD-2p4zA:
undetectable		 3tkgD-2p4zA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  38
GLY A 145
ILE A 149
VAL A  47
ILE A  45
 None
 0.88A 3tl9B-2p4zA:
undetectable		 3tl9B-2p4zA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  38
GLY A 224
ILE A 282
VAL A  13
VAL A  15
 None
 1.05A 3ucbA-2p4zA:
undetectable		 3ucbA-2p4zA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 11 LEU A 252
SER A 221
VAL A  15
LEU A  38
VAL A 186
 None
 1.06A 3w67A-2p4zA:
2.9		 3w67A-2p4zA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A 252
SER A 221
VAL A  15
LEU A  38
VAL A 186
 None
 1.18A 3w68A-2p4zA:
3.2		 3w68A-2p4zA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 10 HIS A  76
HIS A  78
ASP A  80
HIS A 200
HIS A 255
 FE  A1001 (-3.5A)
FE  A1001 (-3.3A)
FE  A1002 (-2.5A)
FE  A1001 (-3.3A)
FE  A1002 (-3.5A)
 0.91A 4c1dB-2p4zA:
4.0		 4c1dB-2p4zA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 11 HIS A  76
HIS A  78
ASP A  80
HIS A 200
HIS A 255
 FE  A1001 (-3.5A)
FE  A1001 (-3.3A)
FE  A1002 (-2.5A)
FE  A1001 (-3.3A)
FE  A1002 (-3.5A)
 0.99A 4c1fA-2p4zA:
10.3
4c1fB-2p4zA:
10.3		 4c1fA-2p4zA:
23.55
4c1fB-2p4zA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 9 HIS A  76
HIS A  78
ASP A  80
HIS A 200
HIS A 255
 FE  A1001 (-3.5A)
FE  A1001 (-3.3A)
FE  A1002 (-2.5A)
FE  A1001 (-3.3A)
FE  A1002 (-3.5A)
 0.92A 4c1hA-2p4zA:
10.0		 4c1hA-2p4zA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 10 GLY A  83
ASP A  80
GLY A  50
HIS A  76
HIS A 255
 None
FE  A1002 (-2.5A)
None
FE  A1001 (-3.5A)
FE  A1002 (-3.5A)
 1.01A 4c5nB-2p4zA:
undetectable		 4c5nB-2p4zA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		4 / 8 HIS A  78
ASP A  80
HIS A 200
HIS A 255
 FE  A1001 (-3.3A)
FE  A1002 (-2.5A)
FE  A1001 (-3.3A)
FE  A1002 (-3.5A)
 0.92A 4exsB-2p4zA:
9.2		 4exsB-2p4zA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		3 / 3 LYS A  96
ILE A  45
THR A  49
 None
 0.84A 4gh8A-2p4zA:
undetectable		 4gh8A-2p4zA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		4 / 8 ILE A 219
LEU A 222
ILE A 149
GLY A 202
 None
 0.87A 4hb6A-2p4zA:
undetectable		 4hb6A-2p4zA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  38
GLY A 145
ILE A 149
VAL A  47
ILE A  45
 None
 0.86A 4hlaA-2p4zA:
undetectable		 4hlaA-2p4zA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 11 LEU A  38
GLY A 145
ILE A 149
VAL A  47
ILE A  45
 None
 0.80A 4hlaB-2p4zA:
undetectable		 4hlaB-2p4zA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		4 / 5 VAL A  66
ARG A  68
GLU A  44
LEU A  18
 None
 0.85A 4hojA-2p4zA:
undetectable		 4hojA-2p4zA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		4 / 5 LEU A 179
ALA A 201
ASN A 158
ILE A 154
 None
 1.20A 4y03B-2p4zA:
undetectable		 4y03B-2p4zA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		4 / 8 HIS A  78
ASP A  80
HIS A 200
HIS A 255
 FE  A1001 (-3.3A)
FE  A1002 (-2.5A)
FE  A1001 (-3.3A)
FE  A1002 (-3.5A)
 0.93A 5a5zA-2p4zA:
8.9		 5a5zA-2p4zA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		6 / 11 HIS A  76
HIS A  78
ASP A  80
HIS A  81
HIS A 200
HIS A 255
 FE  A1001 (-3.5A)
FE  A1001 (-3.3A)
FE  A1002 (-2.5A)
FE  A1002 (-3.4A)
FE  A1001 (-3.3A)
FE  A1002 (-3.5A)
 0.40A 5ayaA-2p4zA:
11.0		 5ayaA-2p4zA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		4 / 7 VAL A  47
ILE A  45
PHE A 146
VAL A 184
 None
 0.66A 5bmvC-2p4zA:
undetectable		 5bmvC-2p4zA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 9 TYR A  79
ILE A 119
ALA A 109
GLU A 117
ARG A 111
 None
 1.41A 5cf9B-2p4zA:
undetectable		 5cf9B-2p4zA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		3 / 3 LEU A 252
PHE A 226
ILE A 273
 None
 0.76A 5dzk1-2p4zA:
undetectable
5dzkF-2p4zA:
undetectable
5dzkM-2p4zA:
undetectable		 5dzk1-2p4zA:
5.41
5dzkF-2p4zA:
21.48
5dzkM-2p4zA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		3 / 3 ASP A  48
VAL A 184
LEU A  38
 None
 0.65A 5e5jB-2p4zA:
undetectable		 5e5jB-2p4zA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 8 HIS A 200
GLY A 225
GLY A 197
HIS A 227
HIS A  76
 FE  A1001 (-3.3A)
None
None
None
FE  A1001 (-3.5A)
 1.32A 5f8yB-2p4zA:
undetectable		 5f8yB-2p4zA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 THR A 257
GLY A 224
ARG A 229
ILE A 259
LEU A 276
 None
 0.96A 5l0zA-2p4zA:
undetectable		 5l0zA-2p4zA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		4 / 6 ASP A  80
HIS A  32
HIS A 255
HIS A 200
 FE  A1002 (-2.5A)
None
FE  A1002 (-3.5A)
FE  A1001 (-3.3A)
 0.85A 5ncdA-2p4zA:
undetectable
5ncdD-2p4zA:
undetectable		 5ncdA-2p4zA:
22.55
5ncdD-2p4zA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		4 / 6 HIS A 200
ASP A  80
HIS A  32
HIS A 255
 FE  A1001 (-3.3A)
FE  A1002 (-2.5A)
None
FE  A1002 (-3.5A)
 0.87A 5ncdB-2p4zA:
undetectable
5ncdC-2p4zA:
undetectable		 5ncdB-2p4zA:
22.55
5ncdC-2p4zA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		4 / 6 ASP A  80
HIS A  32
HIS A 255
HIS A 200
 FE  A1002 (-2.5A)
None
FE  A1002 (-3.5A)
FE  A1001 (-3.3A)
 0.84A 5nelA-2p4zA:
undetectable
5nelD-2p4zA:
undetectable		 5nelA-2p4zA:
22.55
5nelD-2p4zA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		3 / 3 HIS A  76
HIS A 200
HIS A 227
 FE  A1001 (-3.5A)
FE  A1001 (-3.3A)
None
 0.93A 5oexA-2p4zA:
undetectable		 5oexA-2p4zA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		3 / 3 THR A 152
THR A 209
ARG A 213
 None
 0.74A 5wm2A-2p4zA:
undetectable		 5wm2A-2p4zA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		4 / 8 HIS A  78
ASP A  80
HIS A  76
HIS A 255
 FE  A1001 (-3.3A)
FE  A1002 (-2.5A)
FE  A1001 (-3.5A)
FE  A1002 (-3.5A)
 0.93A 5zj8A-2p4zA:
9.4		 5zj8A-2p4zA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		4 / 5 HIS A  76
HIS A  78
PHE A 165
HIS A 200
 FE  A1001 (-3.5A)
FE  A1001 (-3.3A)
None
FE  A1001 (-3.3A)
 0.96A 5zrdB-2p4zA:
undetectable		 5zrdB-2p4zA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		4 / 5 HIS A  78
PHE A 178
HIS A  76
HIS A 200
 FE  A1001 (-3.3A)
None
FE  A1001 (-3.5A)
FE  A1001 (-3.3A)
 0.84A 5zrdB-2p4zA:
undetectable		 5zrdB-2p4zA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 VAL A  23
MET A  62
VAL A  66
THR A  49
GLY A  50
 None
 1.17A 6brdA-2p4zA:
undetectable		 6brdA-2p4zA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A 222
LEU A 204
ILE A 239
VAL A 236
THR A 257
 None
 1.24A 6debB-2p4zA:
undetectable		 6debB-2p4zA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II
(Caldanaerobacter
subterraneus) 		5 / 8 PHE A 183
VAL A 148
GLY A 225
SER A 199
ALA A 201
 None
 1.34A 6hu9H-2p4zA:
undetectable
6hu9e-2p4zA:
undetectable		 6hu9H-2p4zA:
14.44
6hu9e-2p4zA:
17.48