SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p50'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_B_MTXB301_1
(PTERIDINE REDUCTASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 11 ARG A 318
SER A  90
PRO A 277
ASP A  57
HIS A 251
 None
 1.21A 1e7wB-2p50A:
undetectable		 1e7wB-2p50A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 GLU A 131
HIS A 143
HIS A 195
HIS A 216
ASN A 219
 ZN  A 601 (-2.3A)
None
ZN  A 601 (-3.3A)
ZN  A 601 (-3.4A)
None
 1.08A 1ituA-2p50A:
15.5		 1ituA-2p50A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 GLU A 131
HIS A 143
HIS A 195
HIS A 216
ASP A 273
 ZN  A 601 (-2.3A)
None
ZN  A 601 (-3.3A)
ZN  A 601 (-3.4A)
ZN  A 601 ( 4.5A)
 1.13A 1ituA-2p50A:
15.5		 1ituA-2p50A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 GLU A 131
HIS A 143
HIS A 195
HIS A 216
ASP A 273
 ZN  A 601 (-2.3A)
None
ZN  A 601 (-3.3A)
ZN  A 601 (-3.4A)
ZN  A 601 ( 4.5A)
 1.17A 1ituB-2p50A:
14.4		 1ituB-2p50A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 PHE A 207
LEU A 200
ALA A 203
SER A 196
GLY A 233
 None
 1.03A 1kglA-2p50A:
undetectable		 1kglA-2p50A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 ILE A  23
LEU A  51
GLY A  26
GLY A 376
LEU A   4
 None
 0.88A 1liiA-2p50A:
2.7		 1liiA-2p50A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		3 / 3 GLU A 131
HIS A 195
HIS A 143
 ZN  A 601 (-2.3A)
ZN  A 601 (-3.3A)
None
 0.70A 1oe2A-2p50A:
undetectable		 1oe2A-2p50A:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 GLY A 344
LEU A 349
ARG A 348
CYH A 269
PHE A 213
 None
 1.34A 1p93B-2p50A:
undetectable		 1p93B-2p50A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		4 / 6 LEU A 337
GLU A 346
THR A 212
TYR A 242
 None
 1.43A 1qvuA-2p50A:
undetectable		 1qvuA-2p50A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 THR A  11
GLY A  12
GLY A 350
THR A 336
ILE A   9
 None
 1.37A 2akeA-2p50A:
undetectable		 2akeA-2p50A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		3 / 3 ASP A  25
VAL A  22
PRO A  38
 None
 0.75A 2avvA-2p50A:
undetectable		 2avvA-2p50A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 THR A  11
GLY A  12
GLY A 350
THR A 336
ILE A   9
 None
 1.36A 2azxB-2p50A:
undetectable		 2azxB-2p50A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		6 / 12 LEU A 184
ALA A 163
ASP A 164
GLY A 127
VAL A 191
ILE A 189
 None
 1.06A 2hs2A-2p50A:
undetectable		 2hs2A-2p50A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 ILE A 282
ALA A 274
GLY A  62
GLY A  65
THR A  98
 None
 1.10A 2okcA-2p50A:
undetectable		 2okcA-2p50A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 9 ALA A 163
ASP A 164
GLY A 127
VAL A 191
ILE A 189
 None
 1.03A 2q5kA-2p50A:
undetectable		 2q5kA-2p50A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		6 / 12 LEU A 184
ALA A 163
ASP A 164
GLY A 127
VAL A 191
ILE A 189
 None
 1.17A 2q63A-2p50A:
undetectable		 2q63A-2p50A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		3 / 3 LEU A  37
PRO A  38
ARG A  44
 None
 0.58A 2qd5A-2p50A:
undetectable		 2qd5A-2p50A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 VAL A 380
THR A  93
PHE A  55
ALA A  49
PHE A 363
 None
 1.49A 3apxA-2p50A:
undetectable		 3apxA-2p50A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_1
(GLUCOCORTICOID
RECEPTOR)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 GLY A 344
LEU A 349
ARG A 348
CYH A 269
PHE A 213
 None
 1.48A 3cldA-2p50A:
undetectable		 3cldA-2p50A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		3 / 3 MET A   1
CYH A  32
PRO A  38
 None
 1.03A 3h52C-2p50A:
undetectable		 3h52C-2p50A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		6 / 12 LEU A 184
ALA A 163
ASP A 164
GLY A 127
VAL A 191
ILE A 189
 None
 1.22A 3jw2A-2p50A:
undetectable		 3jw2A-2p50A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		6 / 12 LEU A 184
ALA A 163
ASP A 164
GLY A 127
VAL A 191
ILE A 189
 None
 1.25A 3jw2B-2p50A:
undetectable		 3jw2B-2p50A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		6 / 12 LEU A 184
ALA A 163
ASP A 164
GLY A 127
VAL A 191
ILE A 189
 None
 1.27A 3k4vA-2p50A:
undetectable		 3k4vA-2p50A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		3 / 3 SER A 309
ASP A 248
ASN A 319
 None
 0.92A 3lsfB-2p50A:
undetectable
3lsfE-2p50A:
undetectable		 3lsfB-2p50A:
21.14
3lsfE-2p50A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		3 / 3 ASP A 248
ASN A 319
SER A 309
 None
 0.88A 3lsfB-2p50A:
undetectable
3lsfE-2p50A:
undetectable		 3lsfB-2p50A:
21.14
3lsfE-2p50A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		4 / 5 CYH A  63
PRO A  97
THR A  79
THR A 312
 None
 1.40A 3q07A-2p50A:
undetectable		 3q07A-2p50A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		4 / 5 CYH A  63
PRO A  97
THR A  79
THR A 312
 None
 1.39A 3q07B-2p50A:
undetectable		 3q07B-2p50A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		6 / 12 LEU A 184
ALA A 163
ASP A 164
GLY A 127
VAL A 191
ILE A 189
 None
 1.22A 3tl9A-2p50A:
undetectable		 3tl9A-2p50A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 ALA A 178
GLY A 210
ALA A 214
PRO A 173
LEU A 231
 None
 1.17A 3tm4B-2p50A:
undetectable		 3tm4B-2p50A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		4 / 8 LEU A 352
ILE A  28
GLY A 376
ILE A 373
 None
 0.90A 3wxoA-2p50A:
undetectable		 3wxoA-2p50A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 GLY A  62
ALA A 274
THR A 312
PHE A 287
ASP A  70
 None
 1.46A 4df3A-2p50A:
undetectable		 4df3A-2p50A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 GLY A  62
ALA A 274
THR A 312
PHE A 287
ASP A  70
 None
 1.46A 4df3B-2p50A:
undetectable		 4df3B-2p50A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		6 / 10 LEU A 184
ALA A 163
ASP A 164
GLY A 127
VAL A 191
ILE A 189
 None
 1.00A 4dqfB-2p50A:
undetectable		 4dqfB-2p50A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		6 / 12 LEU A 184
ALA A 163
ASP A 164
GLY A 127
VAL A 191
ILE A 189
 None
 1.15A 4jecA-2p50A:
undetectable		 4jecA-2p50A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 10 LEU A 184
ALA A 163
ASP A 164
GLY A 127
VAL A 191
 None
 0.96A 4q1yA-2p50A:
undetectable		 4q1yA-2p50A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 9 ILE A 369
GLY A  54
THR A 336
LEU A 332
LEU A 328
 None
 1.34A 4ze0A-2p50A:
undetectable		 4ze0A-2p50A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		4 / 7 ASP A 301
ILE A 292
GLY A 308
THR A 305
 None
 0.97A 4zxiA-2p50A:
undetectable		 4zxiA-2p50A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		6 / 12 PHE A  68
GLY A  64
ILE A  82
THR A  79
PRO A  97
LEU A 128
 None
 1.41A 5e72A-2p50A:
undetectable		 5e72A-2p50A:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 ILE A 181
GLY A 206
ILE A 189
ALA A 185
VAL A 169
 None
 1.07A 5n0sA-2p50A:
undetectable		 5n0sA-2p50A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 ILE A 181
GLY A 206
ILE A 189
ALA A 185
VAL A 169
 None
 1.10A 5n0tA-2p50A:
undetectable		 5n0tA-2p50A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 ILE A 181
GLY A 206
ILE A 189
ALA A 185
VAL A 169
 None
 1.13A 5n0xA-2p50A:
undetectable		 5n0xA-2p50A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 LEU A 126
GLY A  26
ILE A  56
THR A 361
GLY A 376
 None
 0.90A 5veuH-2p50A:
undetectable		 5veuH-2p50A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		4 / 6 TYR A   2
LEU A 352
LYS A 371
LEU A  51
 None
 1.35A 5xooA-2p50A:
undetectable		 5xooA-2p50A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 LEU A 328
VAL A  21
ARG A   8
ILE A   9
ASP A  17
 None
 1.45A 6bxnA-2p50A:
undetectable		 6bxnA-2p50A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 LEU A 184
ALA A 163
GLY A 127
VAL A 191
ILE A 189
 None
 1.11A 6dgxB-2p50A:
undetectable		 6dgxB-2p50A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 11 THR A 336
PHE A  55
VAL A 317
THR A 372
ILE A 373
 None
 1.44A 6hcoA-2p50A:
undetectable
6hcoB-2p50A:
1.3		 6hcoA-2p50A:
21.43
6hcoB-2p50A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 HIS A 216
SER A 192
HIS A 195
HIS A 143
ASP A 273
 ZN  A 601 (-3.4A)
None
ZN  A 601 (-3.3A)
None
ZN  A 601 ( 4.5A)
 1.20A 6n91A-2p50A:
7.3		 6n91A-2p50A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Escherichia
coli) 		5 / 12 HIS A 216
SER A 192
HIS A 195
HIS A 143
ASP A 273
 ZN  A 601 (-3.4A)
None
ZN  A 601 (-3.3A)
None
ZN  A 601 ( 4.5A)
 1.21A 6n91B-2p50A:
16.0		 6n91B-2p50A:
13.13