SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p57'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 2p57 GTPASE-ACTIVATING
PROTEIN ZNF289
(Homo
sapiens) 		3 / 3 GLU A 116
ALA A 111
SER A 108
 None
 0.67A 1errB-2p57A:
undetectable		 1errB-2p57A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 2p57 GTPASE-ACTIVATING
PROTEIN ZNF289
(Homo
sapiens) 		4 / 6 SER A  35
THR A  66
ASP A  69
TRP A  72
 UNX  A 204 (-3.2A)
None
None
None
 1.17A 1mxdA-2p57A:
undetectable		 1mxdA-2p57A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 2p57 GTPASE-ACTIVATING
PROTEIN ZNF289
(Homo
sapiens) 		4 / 8 SER A  35
THR A  66
ASP A  69
TRP A  72
 UNX  A 204 (-3.2A)
None
None
None
 1.17A 1mxgA-2p57A:
undetectable		 1mxgA-2p57A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_2
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2p57 GTPASE-ACTIVATING
PROTEIN ZNF289
(Homo
sapiens) 		4 / 4 VAL A  58
ARG A  54
HIS A  53
PHE A  62
 None
 1.49A 3apwA-2p57A:
undetectable		 3apwA-2p57A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 2p57 GTPASE-ACTIVATING
PROTEIN ZNF289
(Homo
sapiens) 		3 / 3 LEU A  45
ARG A 115
ASN A 103
 None
 0.66A 3qxvD-2p57A:
undetectable		 3qxvD-2p57A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 2p57 GTPASE-ACTIVATING
PROTEIN ZNF289
(Homo
sapiens) 		5 / 10 CYH A  49
ASP A  28
CYH A  26
GLY A  30
ALA A  31
 ZN  A 201 (-2.3A)
None
ZN  A 201 (-2.3A)
None
ZN  A 201 ( 4.5A)
 1.13A 3ucjA-2p57A:
undetectable		 3ucjA-2p57A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 2p57 GTPASE-ACTIVATING
PROTEIN ZNF289
(Homo
sapiens) 		5 / 10 CYH A  49
ASP A  28
CYH A  26
GLY A  30
ALA A  31
 ZN  A 201 (-2.3A)
None
ZN  A 201 (-2.3A)
None
ZN  A 201 ( 4.5A)
 1.08A 3ucjB-2p57A:
undetectable		 3ucjB-2p57A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 2p57 GTPASE-ACTIVATING
PROTEIN ZNF289
(Homo
sapiens) 		4 / 7 ILE A  39
PHE A  62
TRP A  72
ASP A  69
 None
 1.45A 5nr3A-2p57A:
undetectable		 5nr3A-2p57A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 2p57 GTPASE-ACTIVATING
PROTEIN ZNF289
(Homo
sapiens) 		5 / 10 GLY A  83
GLY A  84
ASN A  85
ILE A 118
ALA A  88
 None
 1.03A 6e5zA-2p57A:
undetectable		 6e5zA-2p57A:
23.20