SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p5d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZN_B_SAMB402_0 (UNCHARACTERIZED PROTEIN MJ0883)	2p5d	UPF0310 PROTEIN MJECL36 (Methanocaldococc us jannaschii)	5 / 12	PHE A 102 TYR A 60 PHE A 108 ILE A 144 ASP A 140	PHE A 102 ( 1.3A) TYR A 60 ( 1.3A) PHE A 108 ( 1.3A) ILE A 144 ( 0.7A) ASP A 140 ( 0.6A)	1.33A	2zznB-2p5dA: undetectable	2zznB-2p5dA: 20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MM4_B_8PRB603_2 (TRANSPORTER)	2p5d	UPF0310 PROTEIN MJECL36 (Methanocaldococc us jannaschii)	3 / 3	SER A 125 MET A 129 ASP A 140	SER A 125 ( 0.0A) MET A 129 ( 0.0A) ASP A 140 ( 0.6A)	0.71A	4mm4B-2p5dA: undetectable	4mm4B-2p5dA: 14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNA_A_ACTA307_0 (THIOREDOXIN REDUCTASE)	2p5d	UPF0310 PROTEIN MJECL36 (Methanocaldococc us jannaschii)	3 / 3	ARG A 62 LYS A 20 TYR A 65	ARG A 62 ( 0.6A) LYS A 20 ( 0.0A) TYR A 65 ( 1.3A)	1.15A	6gnaA-2p5dA: undetectable	6gnaA-2p5dA: 21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNB_A_ACTA307_0 (THIOREDOXIN REDUCTASE)	2p5d	UPF0310 PROTEIN MJECL36 (Methanocaldococc us jannaschii)	3 / 3	ARG A 62 LYS A 20 TYR A 65	ARG A 62 ( 0.6A) LYS A 20 ( 0.0A) TYR A 65 ( 1.3A)	1.15A	6gnbA-2p5dA: undetectable	6gnbA-2p5dA: 21.65

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2ZZN_B_SAMB402_0","UNCHARACTERIZED PROTEIN MJ0883","2p5d","UPF0310 PROTEIN MJECL36","Methanocaldococcus jannaschii",5,"PHE A 102;TYR A  60;PHE A 108;ILE A 144;ASP A 140","PHE A 102 ( 1.3A);TYR A  60 ( 1.3A);PHE A 108 ( 1.3A);ILE A 144 ( 0.7A);ASP A 140 ( 0.6A)","1.33A","2zznB-2p5dA:undetectable","2zznB-2p5dA:20.18"],["4MM4_B_8PRB603_2","TRANSPORTER","2p5d","UPF0310 PROTEIN MJECL36","Methanocaldococcus jannaschii",3,"SER A 125;MET A 129;ASP A 140","SER A 125 ( 0.0A);MET A 129 ( 0.0A);ASP A 140 ( 0.6A)","0.71A","4mm4B-2p5dA:undetectable","4mm4B-2p5dA:14.81"],["6GNA_A_ACTA307_0","THIOREDOXIN REDUCTASE","2p5d","UPF0310 PROTEIN MJECL36","Methanocaldococcus jannaschii",3,"ARG A  62;LYS A  20;TYR A  65","ARG A  62 ( 0.6A);LYS A  20 ( 0.0A);TYR A  65 ( 1.3A)","1.15A","6gnaA-2p5dA:undetectable","6gnaA-2p5dA:21.65"],["6GNB_A_ACTA307_0","THIOREDOXIN REDUCTASE","2p5d","UPF0310 PROTEIN MJECL36","Methanocaldococcus jannaschii",3,"ARG A  62;LYS A  20;TYR A  65","ARG A  62 ( 0.6A);LYS A  20 ( 0.0A);TYR A  65 ( 1.3A)","1.15A","6gnbA-2p5dA:undetectable","6gnbA-2p5dA:21.65"]]