SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p5i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 2p5i BH3822 PROTEIN
(Bacillus
halodurans) 		5 / 11 ALA A 239
LEU A 106
ILE A 129
PHE A 133
THR A 242
 None
 1.02A 1dyrA-2p5iA:
undetectable		 1dyrA-2p5iA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 2p5i BH3822 PROTEIN
(Bacillus
halodurans) 		4 / 8 ALA A  54
LEU A 106
LEU A 236
ALA A 239
 None
 0.70A 1e7cA-2p5iA:
undetectable		 1e7cA-2p5iA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 2p5i BH3822 PROTEIN
(Bacillus
halodurans) 		5 / 11 LEU A 104
ALA A 239
LEU A  52
LEU A 108
VAL A  56
 None
 1.18A 1ictA-2p5iA:
undetectable
1ictC-2p5iA:
undetectable		 1ictA-2p5iA:
20.54
1ictC-2p5iA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_B_SPMB1433_1
(NITROALKANE OXIDASE)		 2p5i BH3822 PROTEIN
(Bacillus
halodurans) 		5 / 11 MET A 132
SER A 107
LEU A 108
VAL A 109
ASP A  36
 None
 1.49A 2c12B-2p5iA:
undetectable		 2c12B-2p5iA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 2p5i BH3822 PROTEIN
(Bacillus
halodurans) 		4 / 7 SER A  32
ARG A  16
LEU A 255
GLU A 259
 None
 0.98A 2cdqB-2p5iA:
0.5		 2cdqB-2p5iA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_2
(MINERALOCORTICOID
RECEPTOR)		 2p5i BH3822 PROTEIN
(Bacillus
halodurans) 		4 / 4 LEU A  63
LEU A  99
MET A 193
CYH A 150
 None
 1.31A 2oaxC-2p5iA:
0.0		 2oaxC-2p5iA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 2p5i BH3822 PROTEIN
(Bacillus
halodurans) 		5 / 12 VAL A 109
SER A 107
LEU A  52
THR A  51
ASN A 105
 None
 1.17A 3a35A-2p5iA:
undetectable		 3a35A-2p5iA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2p5i BH3822 PROTEIN
(Bacillus
halodurans) 		5 / 12 TYR A 149
GLY A 102
SER A 184
VAL A 183
TYR A 180
 None
 1.48A 3hiiA-2p5iA:
0.0		 3hiiA-2p5iA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2p5i BH3822 PROTEIN
(Bacillus
halodurans) 		5 / 12 TYR A 149
GLY A 102
SER A 184
VAL A 183
TYR A 180
 None
 1.50A 3hiiB-2p5iA:
0.0		 3hiiB-2p5iA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 2p5i BH3822 PROTEIN
(Bacillus
halodurans) 		4 / 8 PHE A  27
SER A  32
LEU A  18
ASP A  19
 None
 1.00A 3m0wE-2p5iA:
undetectable
3m0wF-2p5iA:
undetectable
3m0wG-2p5iA:
undetectable
3m0wH-2p5iA:
undetectable		 3m0wE-2p5iA:
20.00
3m0wF-2p5iA:
20.00
3m0wG-2p5iA:
20.00
3m0wH-2p5iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 2p5i BH3822 PROTEIN
(Bacillus
halodurans) 		4 / 7 ALA A 142
ALA A 164
GLY A 165
ILE A 129
 None
 0.64A 4eatA-2p5iA:
undetectable		 4eatA-2p5iA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 2p5i BH3822 PROTEIN
(Bacillus
halodurans) 		5 / 9 ARG A  90
GLY A  94
GLY A  64
PHE A 209
ASP A  67
 None
 1.38A 4h2fA-2p5iA:
undetectable		 4h2fA-2p5iA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 2p5i BH3822 PROTEIN
(Bacillus
halodurans) 		5 / 9 ARG A  90
GLY A  94
GLY A  64
PHE A 209
ASP A  67
 None
 1.35A 4h2gA-2p5iA:
undetectable		 4h2gA-2p5iA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 2p5i BH3822 PROTEIN
(Bacillus
halodurans) 		4 / 6 ILE A 103
ASP A 100
GLY A 187
HIS A  85
 None
 0.94A 4oltA-2p5iA:
1.4		 4oltA-2p5iA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 2p5i BH3822 PROTEIN
(Bacillus
halodurans) 		4 / 6 ILE A 103
ASP A 100
GLY A 187
HIS A  85
 None
 0.97A 4oltB-2p5iA:
undetectable		 4oltB-2p5iA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2p5i BH3822 PROTEIN
(Bacillus
halodurans) 		6 / 12 ILE A 140
ALA A 220
PHE A 163
ILE A 179
LEU A 181
ILE A 129
 None
 1.33A 4pssA-2p5iA:
undetectable		 4pssA-2p5iA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2p5i BH3822 PROTEIN
(Bacillus
halodurans) 		3 / 3 SER A  32
ALA A  29
THR A  60
 None
 0.70A 5n0xB-2p5iA:
undetectable		 5n0xB-2p5iA:
23.32