SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p5s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 2p5s RAS AND EF-HAND
DOMAIN CONTAINING
(Homo
sapiens) 		5 / 12 ALA A 705
LEU A 592
PHE A 557
LEU A 620
ALA A 700
 None
 0.92A 1bzfA-2p5sA:
undetectable		 1bzfA-2p5sA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 2p5s RAS AND EF-HAND
DOMAIN CONTAINING
(Homo
sapiens) 		5 / 10 LEU A 558
LEU A 594
VAL A 698
LEU A 702
VAL A 585
 None
 1.17A 4po0A-2p5sA:
undetectable		 4po0A-2p5sA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 2p5s RAS AND EF-HAND
DOMAIN CONTAINING
(Homo
sapiens) 		3 / 3 SER A 555
LYS A 554
SER A 556
 GDP  A1001 ( 2.5A)
GDP  A1001 ( 2.8A)
GDP  A1001 ( 2.6A)
 0.84A 6az3P-2p5sA:
undetectable		 6az3P-2p5sA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2p5s RAS AND EF-HAND
DOMAIN CONTAINING
(Homo
sapiens) 		5 / 12 PHE A 611
VAL A 545
ILE A 544
TYR A 621
ILE A 632
 None
 1.16A 6mkeB-2p5sA:
undetectable
6mkeC-2p5sA:
undetectable		 6mkeB-2p5sA:
20.30
6mkeC-2p5sA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2p5s RAS AND EF-HAND
DOMAIN CONTAINING
(Homo
sapiens) 		4 / 6 LYS A 578
GLN A 593
LEU A 561
PHE A 557
 None
 1.17A 6nmpC-2p5sA:
undetectable
6nmpJ-2p5sA:
undetectable		 6nmpC-2p5sA:
20.74
6nmpJ-2p5sA:
15.43