SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 2p5t PEZT
(Streptococcus
pneumoniae) 		3 / 3 GLU B 160
ILE B 156
ARG B 205
 None
 0.73A 1cd2A-2p5tB:
undetectable		 1cd2A-2p5tB:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2p5t PEZT
(Streptococcus
pneumoniae) 		4 / 7 PHE B  93
MET B  97
VAL B  98
SER B 100
 None
 1.06A 1wrlA-2p5tB:
undetectable
1wrlB-2p5tB:
undetectable		 1wrlA-2p5tB:
16.33
1wrlB-2p5tB:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2001_1
(SERUM ALBUMIN)		 2p5t PEZT
PUTATIVE
TRANSCRIPTIONAL
REGULATOR PEZA
(Streptococcus
pneumoniae) 		5 / 9 ILE B  62
TYR A  94
GLY B  65
LEU B  22
SER A 119
 None
 1.35A 2bxgB-2p5tB:
0.0		 2bxgB-2p5tB:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_D_BEZD2002_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 2p5t PEZT
(Streptococcus
pneumoniae) 		5 / 9 LEU B 224
PHE B 228
GLN B  40
GLY B  39
LEU B 118
 None
 1.46A 2ok6B-2p5tB:
0.0
2ok6D-2p5tB:
0.0		 2ok6B-2p5tB:
23.48
2ok6D-2p5tB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_H_BEZH2001_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 2p5t PEZT
(Streptococcus
pneumoniae) 		5 / 10 LEU B 224
PHE B 228
GLN B  40
GLY B  39
LEU B 118
 None
 1.45A 2ok6A-2p5tB:
undetectable
2ok6H-2p5tB:
undetectable		 2ok6A-2p5tB:
23.48
2ok6H-2p5tB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 2p5t PEZT
(Streptococcus
pneumoniae) 		4 / 8 ILE B 143
LEU B 224
VAL B 223
LEU B 227
 None
 0.87A 2w98B-2p5tB:
undetectable		 2w98B-2p5tB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2p5t PEZT
(Streptococcus
pneumoniae) 		4 / 7 VAL B  98
VAL B 102
LEU B 105
SER B 106
 None
 0.73A 3hs6B-2p5tB:
undetectable		 3hs6B-2p5tB:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 2p5t PEZT
(Streptococcus
pneumoniae) 		5 / 12 PHE B 228
ASP B 178
SER B 150
LEU B 118
LEU B 142
 None
 1.23A 3ko0M-2p5tB:
undetectable
3ko0N-2p5tB:
undetectable
3ko0O-2p5tB:
undetectable
3ko0P-2p5tB:
undetectable		 3ko0M-2p5tB:
17.25
3ko0N-2p5tB:
17.25
3ko0O-2p5tB:
17.25
3ko0P-2p5tB:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2p5t PUTATIVE
TRANSCRIPTIONAL
REGULATOR PEZA
PEZT
(Streptococcus
pneumoniae;
Streptococcus
pneumoniae) 		3 / 3 THR B  47
ASP A  72
GLU A 130
 None
 0.85A 3qowA-2p5tB:
2.5		 3qowA-2p5tB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 2p5t PEZT
(Streptococcus
pneumoniae) 		4 / 4 LEU B 152
GLY B 243
LEU B 247
GLU B 244
 None
 1.01A 3tgvB-2p5tB:
undetectable		 3tgvB-2p5tB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 2p5t PUTATIVE
TRANSCRIPTIONAL
REGULATOR PEZA
PEZT
(Streptococcus
pneumoniae;
Streptococcus
pneumoniae) 		4 / 6 ARG B  69
GLU A  84
LEU B 161
ASP B  66
 None
 1.24A 4cevA-2p5tB:
2.6
4cevB-2p5tB:
3.4		 4cevA-2p5tB:
21.23
4cevB-2p5tB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 2p5t PUTATIVE
TRANSCRIPTIONAL
REGULATOR PEZA
PEZT
(Streptococcus
pneumoniae;
Streptococcus
pneumoniae) 		4 / 6 ASP B  66
ARG B  69
GLU A  84
LEU B 161
 None
 1.25A 4cevA-2p5tB:
2.3
4cevC-2p5tB:
3.3		 4cevA-2p5tB:
21.23
4cevC-2p5tB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 2p5t PUTATIVE
TRANSCRIPTIONAL
REGULATOR PEZA
PEZT
(Streptococcus
pneumoniae;
Streptococcus
pneumoniae) 		4 / 6 ARG B  69
GLU A  84
LEU B 161
ASP B  66
 None
 1.25A 4cevD-2p5tB:
2.5
4cevE-2p5tB:
3.2		 4cevD-2p5tB:
21.23
4cevE-2p5tB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 2p5t PEZT
(Streptococcus
pneumoniae) 		4 / 7 VAL B  98
MET B  97
ALA B  94
PHE B  93
 None
 1.17A 4lb2A-2p5tB:
undetectable		 4lb2A-2p5tB:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2p5t PEZT
(Streptococcus
pneumoniae) 		3 / 3 LEU B 250
ILE B 156
ARG B 157
 None
 0.61A 4mk4B-2p5tB:
2.9		 4mk4B-2p5tB:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2p5t PEZT
(Streptococcus
pneumoniae) 		5 / 12 ILE B  35
GLN B 139
ALA B 128
ILE B 200
PHE B 197
 None
 1.27A 4rp9A-2p5tB:
undetectable		 4rp9A-2p5tB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 2p5t PUTATIVE
TRANSCRIPTIONAL
REGULATOR PEZA
(Streptococcus
pneumoniae) 		4 / 5 LEU A 118
ASP A 117
TYR A  94
LEU A  93
 None
 1.14A 4wozF-2p5tA:
undetectable
4wozH-2p5tA:
undetectable		 4wozF-2p5tA:
20.98
4wozH-2p5tA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2p5t PEZT
(Streptococcus
pneumoniae) 		5 / 12 LEU B 184
LEU B 227
ALA B 144
LEU B 142
ILE B 200
 None
 1.12A 4x1yB-2p5tB:
2.4		 4x1yB-2p5tB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 2p5t PEZT
PUTATIVE
TRANSCRIPTIONAL
REGULATOR PEZA
(Streptococcus
pneumoniae) 		4 / 6 GLN B 234
SER B 233
ASP B 206
PRO A  69
 None
 1.19A 5c6pA-2p5tB:
undetectable		 5c6pA-2p5tB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2p5t PEZT
(Streptococcus
pneumoniae) 		5 / 11 ALA B 220
LEU B 227
ILE B 143
GLY B  38
LEU B 140
 None
 1.20A 5dxbB-2p5tB:
undetectable		 5dxbB-2p5tB:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2p5t PEZT
(Streptococcus
pneumoniae) 		4 / 8 LEU B 140
ILE B  48
GLY B  39
LEU B 224
 None
 0.88A 5eseA-2p5tB:
undetectable		 5eseA-2p5tB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2p5t PUTATIVE
TRANSCRIPTIONAL
REGULATOR PEZA
PEZT
(Streptococcus
pneumoniae;
Streptococcus
pneumoniae) 		4 / 5 TYR A  73
SER B 150
ALA B  43
GLN B 204
 None
 1.13A 5n0tA-2p5tA:
undetectable		 5n0tA-2p5tA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 2p5t PEZT
PUTATIVE
TRANSCRIPTIONAL
REGULATOR PEZA
(Streptococcus
pneumoniae) 		4 / 7 ARG A  95
SER B  70
ALA A  87
ILE A 145
 None
 1.04A 5te8A-2p5tA:
undetectable		 5te8A-2p5tA:
17.11